ERN2

Description		endoplasmic reticulum to nucleus signaling 2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Endoplasmic Reticulum Quality Control Compartment IRE1-TRAF2-ASK1 Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Catalytic Activity Endonuclease Activity RNA Endonuclease Activity RNA Nuclease Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding Kinase Activity Transferase Activity Hydrolase Activity Metal Ion Binding Unfolded Protein Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of DNA-templated Transcription MRNA Processing RNA Catabolic Process Protein Phosphorylation Apoptotic Process RRNA Catabolic Process Apoptotic Chromosome Condensation Endoplasmic Reticulum Unfolded Protein Response Response To Endoplasmic Reticulum Stress IRE1-mediated Unfolded Protein Response Negative Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Pathways
Drugs
Diseases
GWAS
Novel Interacting Genes		1 novel interacting genes: IL4R
Interacting Genes		1 interacting genes: RNF10
Entrez ID		10595
HPRD ID		04944
Ensembl ID		ENSG00000134398
Uniprot IDs		A5YM46 A5YM65 E7ETG2 Q76MJ5
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation T Cell Differentiation Involved In Immune Response Negative Regulation Of Developmental Process Negative Regulation Of T-helper 1 Cell Differentiation T-helper 2 Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Macrophage Activation Regulation Of Type 2 Immune Response T-helper Cell Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Immunoglobulin Mediated Immune Response Negative Regulation Of T-helper 1 Type Immune Response Interleukin-4-mediated Signaling Pathway Regulation Of Myoblast Fusion B Cell Mediated Immunity Positive Regulation Of Type 2 Immune Response Response To Protozoan Regulation Of Cell Development T-helper 1 Cell Differentiation CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Negative Regulation Of Cell Development Positive Regulation Of T-helper Cell Differentiation Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Mast Cell Degranulation Cytokine Receptor Activity Defense Response To Protozoan Production Of Molecular Mediator Involved In Inflammatory Response Interleukin-4 Receptor Activity Negative Regulation Of CD4-positive, Alpha-beta T Cell Activation Negative Regulation Of T-helper Cell Differentiation Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Myoblast Fusion Regulation Of Mast Cell Degranulation Negative Regulation Of Alpha-beta T Cell Activation Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Postsynaptic Signal Transduction Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Positive Regulation Of Myelination Negative Regulation Of Schwann Cell Proliferation Negative Regulation Of Glial Cell Proliferation Regulation Of Myelination Extrinsic Component Of Postsynaptic Density Membrane Regulation Of T-helper Cell Differentiation
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