IL2RA and CALML3

Data Source: HiPPIP (Novel)

		IL2RA	CALML3
Name		interleukin 2 receptor subunit alpha	calmodulin like 3
Structure
GO Annotations	Cellular Component	Plasma Membrane Interleukin-2 Receptor Complex External Side Of Plasma Membrane Cell Surface Membrane	Cytoplasm Centrosome Synaptic Vesicle Membrane Myelin Sheath Extracellular Exosome
	Molecular Function	Interleukin-2 Receptor Activity Protein Binding Interleukin-2 Binding	Calcium Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Immune System Process Inflammatory Response To Antigenic Stimulus Regulation Of T Cell Tolerance Induction Regulation Of Immune System Process Apoptotic Process Activation-induced Cell Death Of T Cells Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway Notch Signaling Pathway Interleukin-2-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Proliferation T Cell Homeostasis Positive Regulation Of T Cell Differentiation Regulation Of T Cell Homeostatic Proliferation Lymphocyte Proliferation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Inflammatory Response Activated T Cell Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Proliferation	Detection Of Calcium Ion Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcineurin-mediated Signaling
Pathways		RAF/MAP kinase cascade RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Interleukin-2 signaling Interleukin receptor SHC signaling	None
Drugs		Denileukin diftitox Aldesleukin Basiliximab Daclizumab Inolimomab Camidanlumab tesirine	None
Diseases		Type I diabetes mellitus T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma	None
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406 ) Alopecia areata ( 20596022 25608926 ) Arthritis (juvenile idiopathic) ( 33106285 ) Asthma ( 34103634 31959851 31619474 31361310 30929738 32296059 ) Asthma (adult onset) ( 30929738 ) Asthma (bronchodilator response) ( 23508266 ) Asthma (childhood onset) ( 30929738 ) Asthma and hay fever ( 24388013 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Atopic dermatitis ( 26482879 ) Autoimmune thyroid disease ( 32581359 ) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229 ) Autoimmune traits (pleiotropy) ( 30572963 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 28067908 21102463 ) Diisocyanate-induced asthma ( 25918132 ) Eczema ( 31361310 ) Emotional dysregulation ( 27643478 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Epstein Barr virus nuclear antigen 1 IgG levels or multiple sclerosis ( 26819262 ) Graves' disease ( 22922229 ) Inflammatory biomarkers ( 22228203 ) Inflammatory bowel disease ( 23128233 ) Interleukin-2 receptor antagonist levels ( 27989323 ) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761 ) Liver fibrogenesis (alpha smooth muscle actin levels) ( 32953199 ) Lymphocyte count ( 32888494 27863252 ) Lymphocyte percentage of white cells ( 32888494 27863252 ) Marginal zone lymphoma or multiple sclerosis ( 31407831 ) Medication use (thyroid preparations) ( 31015401 ) Multiple sclerosis ( 31604244 19525953 17660530 19525955 21833088 28445677 24076602 22190364 27386562 ) Neutrophil percentage of white cells ( 32888494 ) Pediatric autoimmune diseases ( 26301688 ) Plasma t-tau levels ( 28100725 ) Primary sclerosing cholangitis ( 27992413 23603763 ) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482 ) Rheumatoid arthritis ( 30572963 30423114 24449572 24390342 23143596 ) Rheumatoid arthritis (ACPA-positive) ( 23143596 ) Selective IgA deficiency ( 27723758 ) Soluble interleukin-2 receptor subunit alpha ( 26293465 ) Systemic lupus erythematosus ( 28714469 ) Type 1 diabetes ( 30572963 25751624 22293688 21829393 19430480 18978792 ) Vitiligo ( 27723757 20410501 ) White blood cell count ( 32888494 )	Fasting insulin ( 34074324 )
Novel Interactors		9 novel interactors: AKR1C3 ARHGAP12 CALML3 FGF12 FKBP4 GTPBP4 JCAD KIN PFKP	1 novel interactors: IL2RA
Interacting Genes		8 interacting genes: CD4 ICAM1 IL2 IL2RB NFKB1 SNTA1 STAT3 STAT5B	9 interacting genes: BHLHE40 C11orf65 IQCB1 IQCN ISOC2 MAPK4 MFHAS1 MYO10 TERF2IP
Entrez ID		3559	810
HPRD ID		00986	00244
Ensembl ID		ENSG00000134460	ENSG00000178363
Uniprot IDs		H0Y5Z0 P01589 Q5W005	P27482
PDB IDs		1Z92 2B5I 2ERJ 3IU3 3NFP 6VWU 6YIO 7F9W 7ZMZ	1GGZ
GO Terms Enriched among Interactors		Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Nuclear Glucocorticoid Receptor Binding Cytokine-mediated Signaling Pathway Response To Peptide Response To Cytokine Positive Regulation Of Inflammatory Response Cellular Response To Interleukin-17 Activated T Cell Proliferation Cellular Response To Cytokine Stimulus Regulation Of Vitamin Metabolic Process Cell Surface Receptor Signaling Pathway Via STAT Immune Response Progesterone Metabolic Process Growth Hormone Receptor Signaling Pathway Via JAK-STAT Response To Alcohol Regulation Of Monoatomic Cation Transmembrane Transport Intracellular Signaling Cassette Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Cell Population Proliferation Response To Estradiol Positive Regulation Of T Cell Proliferation Adaptive Immune Response Positive Regulation Of Myeloid Cell Differentiation T Cell Activation Positive Regulation Of B Cell Differentiation Transcription By RNA Polymerase II Negative Regulation Of Small Molecule Metabolic Process Regulation Of Steroid Metabolic Process Response To Ethanol Growth Hormone Receptor Signaling Pathway C21-steroid Hormone Metabolic Process Regulation Of Metal Ion Transport Sex Differentiation Positive Regulation Of Activated T Cell Proliferation Cellular Response To Hormone Stimulus Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation T Cell Differentiation Regulation Of Transport Sodium Channel Regulator Activity Immune Effector Process Signal Transduction Regulation Of Monoatomic Ion Transport Regulation Of Cell Population Proliferation Positive Regulation Of Leukocyte Proliferation Positive Regulation Of Interleukin-2 Production Regulation Of Sodium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Inflammatory Response	None