HHIP

Gene Name		hedgehog interacting protein
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Integral Component Of Plasma Membrane Cell Surface Ciliary Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, Quinone Or Similar Compound As Acceptor Quinone Binding Hedgehog Family Protein Binding
	Biological Process	Carbohydrate Metabolic Process Smoothened Signaling Pathway Neuroblast Proliferation Dorsal/ventral Pattern Formation Negative Regulation Of Signal Transduction Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Smoothened Signaling Pathway Skeletal System Morphogenesis Oxidation-reduction Process Epithelial Tube Branching Involved In Lung Morphogenesis
Pathways		Hedgehog 'on' state Signaling by Hedgehog Ligand-receptor interactions
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 22080838 19300482 20173748) Height ( 20881960 19343178 23563607 18391950 18391951 18391952 20397748) Pulmonary function ( 20010834 20010835 19300500) Pulmonary function (interaction) ( 23284291)
Protein-protein Interactions		3 interactors: DHH IHH SHH
Entrez ID		64399
HPRD ID		06937
Ensembl ID
Uniprot IDs		Q96QV1
PDB IDs		2WFT 2WFX 2WG3 2WG4 3HO3 3HO4 3HO5
Enriched GO Terms of Interacting Partners?		Intein-mediated Protein Splicing Negative Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Alpha-beta T Cell Activation Embryonic Digestive Tract Morphogenesis Regulation Of T Cell Differentiation In Thymus Negative Regulation Of T Cell Differentiation Embryonic Digestive Tract Development Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Lymphocyte Differentiation Regulation Of Mesenchymal Cell Proliferation Patterning Of Blood Vessels Positive Regulation Of Smoothened Signaling Pathway Heart Looping Negative Regulation Of T Cell Proliferation Determination Of Heart Left/right Asymmetry Embryonic Heart Tube Morphogenesis Digestive Tract Morphogenesis Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Stem Cell Proliferation Developmental Process Involved In Reproduction Negative Regulation Of Leukocyte Proliferation Neuron Fate Commitment Positive Regulation Of T Cell Differentiation Embryonic Heart Tube Development Embryonic Pattern Specification Positive Regulation Of Lymphocyte Differentiation Regulation Of Smoothened Signaling Pathway Cell Fate Specification Pancreas Development Somite Development Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion Cell-cell Signaling Negative Regulation Of Homotypic Cell-cell Adhesion Determination Of Left/right Symmetry Regulation Of Stem Cell Proliferation Determination Of Bilateral Symmetry Smoothened Signaling Pathway Response To Estradiol Regulation Of T Cell Differentiation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Digestive Tract Development Osteoblast Differentiation Regulation Of T Cell Proliferation Digestive System Development Negative Regulation Of Ureter Smooth Muscle Cell Differentiation
Tagcloud ?		augmented beta1 branching bud dams dysmorphogenesis dysnephrogenesis hedgehog heightened hypothesised impairs kidneys kip1 localised maternal maturing mesenchyme metanephric morphogenesis nfkappab offspring pax2 progeny retardation shh sonic tubulointerstitial ub ureteric