HHIP and SHH

Number of citations of the paper that reports this interaction (PMID 10050855)
113

Data Source:
HPRD (in vivo)

		HHIP	SHH
Gene Name		hedgehog interacting protein	sonic hedgehog
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Integral Component Of Plasma Membrane Cell Surface Ciliary Membrane	Extracellular Region Extracellular Space Nucleus Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Cell Surface Extracellular Matrix Membrane Raft
	Molecular Function	Protein Binding Zinc Ion Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, Quinone Or Similar Compound As Acceptor Quinone Binding Hedgehog Family Protein Binding	Glycoprotein Binding Patched Binding Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Peptidase Activity Zinc Ion Binding Morphogen Activity Laminin-1 Binding
	Biological Process	Carbohydrate Metabolic Process Smoothened Signaling Pathway Neuroblast Proliferation Dorsal/ventral Pattern Formation Negative Regulation Of Signal Transduction Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Smoothened Signaling Pathway Skeletal System Morphogenesis Oxidation-reduction Process Epithelial Tube Branching Involved In Lung Morphogenesis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Patterning Of Blood Vessels Vasculogenesis Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Cell Fate Specification Neural Crest Cell Migration Heart Looping Positive Regulation Of Neuroblast Proliferation Osteoblast Development Lymphoid Progenitor Cell Differentiation Determination Of Left/right Asymmetry In Lateral Mesoderm Proteolysis Endocytosis Smoothened Signaling Pathway Positive Regulation Of Hh Target Transcription Factor Activity Cell-cell Signaling Pattern Specification Process Ectoderm Development Neuroblast Proliferation Axon Guidance Central Nervous System Development Ventral Midline Development Hindgut Morphogenesis Heart Development Blood Coagulation Androgen Metabolic Process Positive Regulation Of Cell Proliferation Embryo Development Embryonic Pattern Specification Polarity Specification Of Anterior/posterior Axis Dorsal/ventral Pattern Formation Oligodendrocyte Development Striated Muscle Tissue Development Positive Regulation Of Skeletal Muscle Cell Proliferation Myotube Differentiation Intein-mediated Protein Splicing Spinal Cord Dorsal/ventral Patterning Spinal Cord Motor Neuron Differentiation Thalamus Development Dorsal/ventral Neural Tube Patterning Cerebellar Granule Cell Precursor Proliferation Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Telencephalon Regionalization Establishment Of Cell Polarity Regulation Of Proteolysis Positive Regulation Of Wnt Signaling Pathway Lung Development Embryonic Limb Morphogenesis Negative Regulation Of Cell Migration Male Genitalia Development Prostate Gland Development Thyroid Gland Development Forebrain Development Midbrain Development Hindbrain Development Pancreas Development Hair Follicle Morphogenesis Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process T Cell Differentiation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Immature T Cell Proliferation In Thymus Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Protein Localization To Nucleus Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Regulation Of Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Regulation Of Odontogenesis Embryonic Digit Morphogenesis Camera-type Eye Development Negative Regulation Of Apoptotic Process CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Positive Thymic T Cell Selection Negative Thymic T Cell Selection Intermediate Filament Organization Myoblast Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Cell Development Thymus Development Embryonic Digestive Tract Morphogenesis Embryonic Foregut Morphogenesis Positive Regulation Of Skeletal Muscle Tissue Development Organ Formation Neuron Fate Commitment Embryonic Skeletal System Development Positive Regulation Of Oligodendrocyte Differentiation Branching Morphogenesis Of An Epithelial Tube Inner Ear Development Formation Of Anatomical Boundary Stem Cell Development Positive Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Cell Division Bergmann Glial Cell Differentiation Palate Development Canonical Wnt Signaling Pathway Limb Bud Formation Lung Epithelium Development Trachea Morphogenesis Branching Involved In Salivary Gland Morphogenesis Bud Outgrowth Involved In Lung Branching Right Lung Development Left Lung Development Lung Lobe Morphogenesis Lung-associated Mesenchyme Development Primary Prostatic Bud Elongation Prostate Epithelial Cord Elongation Salivary Gland Cavitation Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Regulation Of Prostatic Bud Formation Epithelial-mesenchymal Signaling Involved In Prostate Gland Development Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Regulation Of Mesenchymal Cell Proliferation Involved In Prostate Gland Development Mesenchymal Smoothened Signaling Pathway Involved In Prostate Gland Development Artery Development Mesenchymal Cell Proliferation Involved In Lung Development Somite Development Positive Regulation Of Sclerotome Development Cellular Response To Lithium Ion Renal System Development Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Multicellular Structure Septum Development Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cholesterol Efflux Apoptotic Signaling Pathway Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Regulation Of Protein Localization To Nucleus Negative Regulation Of Ureter Smooth Muscle Cell Differentiation Positive Regulation Of Ureter Smooth Muscle Cell Differentiation Negative Regulation Of Kidney Smooth Muscle Cell Differentiation Positive Regulation Of Kidney Smooth Muscle Cell Differentiation Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Negative Regulation Of Mesenchymal Cell Apoptotic Process
Pathways		Hedgehog 'on' state Signaling by Hedgehog Ligand-receptor interactions	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Hedgehog ligand biogenesis Processing-defective Hh variants abrogate ligand secretion Hh ligand biogenesis disease GPCR ligand binding Metabolic disorders of biological oxidation enzymes Ligand-receptor interactions Release of Hh-Np from the secreting cell Hedgehog 'on' state Signaling by Hedgehog Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 22080838 19300482 20173748) Height ( 20881960 19343178 23563607 18391950 18391951 18391952 20397748) Pulmonary function ( 20010834 20010835 19300500) Pulmonary function (interaction) ( 23284291)	Corneal astigmatism ( 23322567) Platelet aggregation ( 20526338)
Protein-Protein Interactions		3 interactors: DHH IHH SHH	5 interactors: ADCYAP1 GAS1 HHIP PTCH1 PTCH2
Entrez ID		64399	6469
HPRD ID		06937	02838
Ensembl ID
Uniprot IDs		Q96QV1	Q15465
PDB IDs		2WFT 2WFX 2WG3 2WG4 3HO3 3HO4 3HO5	3HO5 3M1N 3MXW
Enriched GO Terms of Interacting Partners?		Intein-mediated Protein Splicing Negative Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Alpha-beta T Cell Activation Embryonic Digestive Tract Morphogenesis Regulation Of T Cell Differentiation In Thymus Negative Regulation Of T Cell Differentiation Embryonic Digestive Tract Development Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Lymphocyte Differentiation Regulation Of Mesenchymal Cell Proliferation Patterning Of Blood Vessels Positive Regulation Of Smoothened Signaling Pathway Heart Looping Negative Regulation Of T Cell Proliferation Determination Of Heart Left/right Asymmetry Embryonic Heart Tube Morphogenesis Digestive Tract Morphogenesis Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Stem Cell Proliferation Developmental Process Involved In Reproduction Negative Regulation Of Leukocyte Proliferation Neuron Fate Commitment Positive Regulation Of T Cell Differentiation Embryonic Heart Tube Development Embryonic Pattern Specification Positive Regulation Of Lymphocyte Differentiation Regulation Of Smoothened Signaling Pathway Cell Fate Specification Pancreas Development Somite Development Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion Cell-cell Signaling Negative Regulation Of Homotypic Cell-cell Adhesion Determination Of Left/right Symmetry Regulation Of Stem Cell Proliferation Determination Of Bilateral Symmetry Smoothened Signaling Pathway Response To Estradiol Regulation Of T Cell Differentiation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Digestive Tract Development Osteoblast Differentiation Regulation Of T Cell Proliferation Digestive System Development Negative Regulation Of Ureter Smooth Muscle Cell Differentiation	Negative Regulation Of Smoothened Signaling Pathway Regulation Of Smoothened Signaling Pathway Dorsal/ventral Pattern Formation Dorsal/ventral Neural Tube Patterning Epithelium Development Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Signaling Neural Tube Patterning Pattern Specification Process Generation Of Neurons Neurogenesis Tissue Development Positive Regulation Of Somatostatin Secretion Negative Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Negative Regulation Of Cell Proliferation Smoothened Signaling Pathway Tube Development Negative Regulation Of Epithelial Cell Proliferation Brain Development Head Development Anatomical Structure Development Neural Plate Axis Specification Response To Chlorate Nervous System Development Embryonic Limb Morphogenesis Regulation Of Cell Cycle Limb Morphogenesis Central Nervous System Development Neural Tube Development Developmental Process Limb Development Organ Morphogenesis Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Morphogenesis Of A Branching Epithelium Neuron Differentiation Negative Regulation Of Growth Morphogenesis Of A Branching Structure Organ Development Epidermis Development Skeletal System Morphogenesis Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Regulation Of Epithelial Cell Proliferation Positive Regulation Of Growth Hormone Secretion Cellular Response To Stimulus Cell Proliferation Involved In Metanephros Development Cell Differentiation
Tagcloud ?		augmented beta1 branching bud dams dysmorphogenesis dysnephrogenesis hedgehog heightened hypothesised impairs kidneys kip1 localised maternal maturing mesenchyme metanephric morphogenesis nfkappab offspring pax2 progeny retardation shh sonic tubulointerstitial ub ureteric	asked beyond dopaminergic dorsal e14 e15 embryogenesis exclusion gaba ganglion hedgehog immunoreactive interneurons lim mesencephalon midbrain motorneuron neuron neurotoxin notochord persists promotes sonic specification striatum sympathetic trophic ventral vertebrate
Tagcloud (Difference) ?		augmented beta1 branching bud dams dysmorphogenesis dysnephrogenesis heightened hypothesised impairs kidneys kip1 localised maternal maturing mesenchyme metanephric morphogenesis nfkappab offspring pax2 progeny retardation tubulointerstitial ub ureteric	asked beyond dopaminergic dorsal e14 e15 embryogenesis exclusion gaba ganglion immunoreactive interneurons lim mesencephalon midbrain motorneuron neuron neurotoxin notochord persists promotes specification striatum sympathetic trophic ventral vertebrate
Tagcloud (Intersection) ?		hedgehog shh sonic