KRTAP12-1 and HOXC8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRTAP12-1	HOXC8
Description		keratin associated protein 12-1	homeobox C8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament Keratin Filament	Chromatin Nucleus Nucleoplasm Microtubule Cytoskeleton
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Neuron Differentiation Skeletal System Morphogenesis
Pathways		Keratinization	Regulation of CDH11 gene transcription Regulation of CDH11 gene transcription
Drugs
Diseases
GWAS			Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		62 interacting genes: CATSPER1 CHRD CYSRT1 DHRS1 ENKD1 FHL3 GATA3 GPRIN2 GRN HOXA1 HOXC8 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-2 KRTAP12-3 KRTAP15-1 KRTAP26-1 KRTAP3-2 KRTAP4-4 KRTAP4-5 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP9-2 KRTAP9-3 LCE1A LCE1B LCE1C LCE1E LCE1F LCE2A LCE2B LCE2C LCE3A LCE5A MEOX2 MGAT5B NBPF19 NEU4 NOTCH2NLA OTX1 PDIA2 PDIA4 PEF1 POU2AF1 POU4F2 PRR35 RBPMS SMCP TOX TRIP13 UBQLN2 VGLL3 ZIC1	108 interacting genes: ACTMAP ADAMTSL4 AIRIM ANKS1A BLZF1 BMPR1A BTG2 CADPS CCM2 CEP70 CFAP68 CRYBA1 CYSRT1 DLX2 DLX5 DVL3 DZIP3 ECM1 FNTB GMNN GOLGA6L9 GSTO2 GYS1 HESX1 HOMEZ HOXD3 HSF2BP IKZF3 JUN KCTD9 KHDC1 KPRP KRT31 KRT34 KRT35 KRT36 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP13-3 KRTAP19-2 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LDLRAP1 LDOC1 LHX2 LHX3 LRP2BP MAPK8IP2 MEOX1 MEOX2 METTL15 MGAT5B MSX1 NADSYN1 NBPF19 NFKBID NID2 NOTCH2NLA OIP5 PAX5 PAX6 PAX8 PBX1 PBX2 PBX4 PDE4DIP PFDN5 PLA2G10 PLEKHG4 POU2AF1 POU6F2 PPARA PRDM14 PRDM6 RBCK1 RBPMS SLAIN1 SMAD1 SMAD4 SMAD6 SNX17 TBC1D1 TBX19 TBX22 TEKT4 TLE5 TNS2 TRAF1 TRIB3 TRIM27 TRIM42 TRIP6 TSC1 USP54 VENTX WWOX ZFP90 ZMAT5 ZNF34 ZRANB1
Entrez ID		353332	3224
HPRD ID		11197	00856
Ensembl ID		ENSG00000187175	ENSG00000037965
Uniprot IDs		P59990	P31273
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Identical Protein Binding Protein Binding	Intermediate Filament Keratin Filament DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Anatomical Structure Morphogenesis Protein Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Pituitary Gland Development Positive Regulation Of RNA Metabolic Process Regionalization RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Regulation Of RNA Metabolic Process Developmental Process Cellular Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding SMAD Protein Signal Transduction Regulation Of MiRNA Transcription Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Morphogenesis Gland Development Sequence-specific DNA Binding Positive Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Sensory Organ Development Animal Organ Development Structural Constituent Of Skin Epidermis Regulation Of Nucleobase-containing Compound Metabolic Process Tissue Development Cardiac Conduction System Development Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Muscle Cell Differentiation Transcription Cis-regulatory Region Binding Epithelial Cell Differentiation DNA Binding Heteromeric SMAD Protein Complex Cell Fate Specification BMP Signaling Pathway Sequence-specific Double-stranded DNA Binding Epithelium Development R-SMAD Binding Cell Differentiation Embryonic Pattern Specification
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