LCE3E and CHIC2

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		LCE3E	CHIC2
Description		late cornified envelope 3E	cysteine rich hydrophobic domain 2
Image		No pdb structure
GO Annotations	Cellular Component		Golgi Apparatus Golgi-associated Vesicle Plasma Membrane Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Epidermis Development Keratinization
Pathways		Formation of the cornified envelope
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Common traits (Other) ( 20585627) Inflammatory skin disease ( 25574825) Plantar warts ( 28928442) Psoriasis ( 25854761)	Blood pressure ( 21909110) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Metabolite levels ( 23823483) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulse pressure ( 28739976 30487518) Serum metabolite levels (CMS) ( 31636271) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		59 interacting genes: ADAMTSL4 ALPP CHIC2 CYSRT1 EFEMP2 GRN GSC2 HOXA1 KPRP KRT31 KRT40 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE2A MACO1 MDFI NBPF19 NOTCH2NLA NXF1 PLSCR2 RGS17 RGS20 SPRY1 SPRY2 SPRY3 TRIM42 VWC2	68 interacting genes: ADAMTSL4 AGXT AXIN2 C1QTNF2 CARD10 CATSPER1 CBY2 CDR2 CEP44 CYSRT1 DNAL4 FBLN1 GMCL1 HOXA1 ITSN2 KANK2 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP6-2 LCE1A LCE1B LCE1C LCE1D LCE1F LCE2C LCE3A LCE3C LCE3D LCE3E LCE5A LCN2 LZTS2 MDFI MEOX2 MTUS2 MYF5 MYPOP NBPF19 NDUFB7 NOTCH2NLA OTX1 PLEKHF1 PLEKHF2 PLEKHG4 PNMA1 POU4F2 PPARA REL SCNM1 SDCBP TCF4 TOP3B TUBGCP4 U2AF2 ZNF330 ZNF837
Entrez ID		353145	26511
HPRD ID		13975	10373
Ensembl ID		ENSG00000185966	ENSG00000109220
Uniprot IDs		Q5T5B0	Q9UKJ5
PDB IDs			8SUV
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Hair Cycle Cytosol Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Epidermis Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Bud Elongation Involved In Lung Branching Interstitial Matrix Regulation Of Lens Fiber Cell Differentiation Protein Binding Regulation Of Ras Protein Signal Transduction Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Branch Elongation Of An Epithelium Structural Constituent Of Skin Epidermis Negative Regulation Of Small GTPase Mediated Signal Transduction	Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Identical Protein Binding Regulation Of Transformation Of Host Cell By Virus Protein Binding
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