LCE3E and PLSCR2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LCE3E	PLSCR2
Description		late cornified envelope 3E	phospholipid scramblase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Endoplasmic Reticulum Plasma Membrane Membrane
	Molecular Function	Protein Binding	Calcium Ion Binding Protein Binding Phospholipid Scramblase Activity Metal Ion Binding
	Biological Process	Epidermis Development Keratinization	Plasma Membrane Phospholipid Scrambling
Pathways		Formation of the cornified envelope
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Common traits (Other) ( 20585627) Inflammatory skin disease ( 25574825) Plantar warts ( 28928442) Psoriasis ( 25854761)	Hip circumference ( 28552196)
Interacting Genes		59 interacting genes: ADAMTSL4 ALPP CHIC2 CYSRT1 EFEMP2 GRN GSC2 HOXA1 KPRP KRT31 KRT40 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE2A MACO1 MDFI NBPF19 NOTCH2NLA NXF1 PLSCR2 RGS17 RGS20 SPRY1 SPRY2 SPRY3 TRIM42 VWC2	15 interacting genes: AQP1 BSND COQ9 EP300 FAM221B GNG13 HOXA1 LCE1A LCE3A LCE3E LCE5A LYPD1 OTX1 POU4F2 TMEM132D
Entrez ID		353145	57047
HPRD ID		13975	09621
Ensembl ID		ENSG00000185966	ENSG00000163746
Uniprot IDs		Q5T5B0	Q9NRY7
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Hair Cycle Cytosol Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Epidermis Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Bud Elongation Involved In Lung Branching Interstitial Matrix Regulation Of Lens Fiber Cell Differentiation Protein Binding Regulation Of Ras Protein Signal Transduction Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Branch Elongation Of An Epithelium Structural Constituent Of Skin Epidermis Negative Regulation Of Small GTPase Mediated Signal Transduction	Keratinization Tissue Development Epidermis Development Sensory Perception Nervous System Process Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Nitric Oxide Transmembrane Transporter Activity Metanephric Proximal Convoluted Tubule Segment 2 Development Behavioral Defense Response Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Sensory Perception Of Sound Sensory Perception Of Mechanical Stimulus Semicircular Canal Formation Diencephalon Morphogenesis Isoprenoid Binding Metanephric Glomerulus Vasculature Development Glycerol Transmembrane Transporter Activity Corticotropin Secretion System Process Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Abducens Nerve Formation Optokinetic Behavior P53 Binding
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