IL34

Description		interleukin 34
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Growth Factor Activity Identical Protein Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Immune System Process Inflammatory Response Positive Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cell Development Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of MAPK Cascade Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Monocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Multicellular Organismal Process Interleukin-34-mediated Signaling Pathway Microglial Cell Proliferation Positive Regulation Of Macrophage Proliferation Regulation Of Multicellular Organismal Development
Pathways		Other interleukin signaling Signaling by CSF1 (M-CSF) in myeloid cells
Drugs
Diseases
GWAS		Alzheimer's disease ( 34099642) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Cerebrospinal P-tau181p levels ( 28247064) Diffuse cutaneous systemic sclerosis ( 29293537) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Intraocular pressure ( 29785010 30054594) Malaria ( 31844061)
Interacting Genes		3 interacting genes: ATXN1 LCE1F PTPRZ1
Entrez ID		146433
HPRD ID		14582
Ensembl ID		ENSG00000157368
Uniprot IDs		J3QQT3 Q6ZMJ4
PDB IDs		4DKC 4DKD 4DKE 4DKF
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gliogenesis Regulation Of Gliogenesis Learning Or Memory Positive Regulation Of Neurogenesis Positive Regulation Of Nervous System Development POZ Domain Binding Regulation Of Oligodendrocyte Progenitor Proliferation Cognition Positive Regulation Of Cell Development Regulation Of Neurogenesis Regulation Of Nervous System Development Perineuronal Net Poly(G) Binding Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Nuclear Inclusion Body Transmembrane Receptor Protein Tyrosine Phosphatase Activity Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Oligodendrocyte Differentiation Poly(U) RNA Binding Positive Regulation Of Glial Cell Proliferation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Oligodendrocyte Differentiation Positive Regulation Of Glial Cell Differentiation Regulation Of Oligodendrocyte Differentiation Regulation Of Cell Development Regulation Of Myelination Nervous System Process Positive Regulation Of Cell Differentiation Regulation Of Glial Cell Proliferation Insulin-like Growth Factor Receptor Signaling Pathway Lung Alveolus Development
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