EPDR1 and PM20D2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		EPDR1	PM20D2
Name		ependymin related 1	peptidase M20 domain containing 2
Structure
GO Annotations	Cellular Component	Extracellular Region Lysosome Lysosomal Lumen	Nucleoplasm Cytoplasm
	Molecular Function	Calcium Ion Binding Protein Binding Phospholipid Binding Lipid Binding Identical Protein Binding Ganglioside GM1 Binding	Carboxypeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity Dipeptidase Activity Identical Protein Binding Para-aminobenzoyl-glutamate Hydrolase Activity
	Biological Process	Cell-matrix Adhesion Myofibroblast Contraction	Proteolysis Folic Acid Catabolic Process Regulation Of Protein Metabolic Process
GWAS		Dupuytren's disease ( 21732829 28886342 ) Glaucoma (primary angle closure) ( 27064256 ) Heel bone mineral density ( 28869591 30598549 ) Height ( 31562340 ) Lateral ventricle volume ( 31530798 ) Lumbar spine bone mineral density ( 29499414 ) Rosacea symptom severity ( 29771307 )	Serum metabolite levels ( 33031748 )
Interacting Genes		13 interacting genes: ADAMTSL4 EHMT2 HOXA1 IGFBP6 KRT31 KRT34 KRTAP10-8 KRTAP13-2 KRTAP4-11 PM20D2 TNS2 TRIP6 UBQLN4	24 interacting genes: CERT1 CNNM3 DALRD3 DDIT4L DNAJC11 EPDR1 HAPLN2 KEL KRT75 KRTAP26-1 MEOX1 MYOZ3 NAA80 OGT POU6F2 PSMA1 REL RGS12 RP2 RUSC1 SAXO1 SIVA1 TAPBPL TDO2
Entrez ID		54749	135293
HPRD ID		16865	16473
Ensembl ID		ENSG00000086289	ENSG00000146281
Uniprot IDs		Q96J80 Q9UM22	Q8IYS1
PDB IDs		6E7O 6E8N 6JLD	7YH4 8XZC
GO Terms Enriched among Interactors		Keratin Filament Intermediate Filament Identical Protein Binding Structural Molecule Activity Negative Regulation Of Macroautophagy Semicircular Canal Formation Insulin-like Growth Factor Binary Complex Histone H3K56 Methyltransferase Activity Pigment Cell Development Para-aminobenzoyl-glutamate Hydrolase Activity Structural Constituent Of Skin Epidermis Abducens Nerve Formation Optokinetic Behavior Intermediate Filament Organization Nuclear Proteasome Complex Folic Acid Catabolic Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Phenotypic Switching Negative Regulation Of Autophagosome Maturation Kinase Binding Negative Regulation Of Autophagy	None