IGFBP4 and MX2

Data Source: HiPPIP (Novel)

		IGFBP4	MX2
Name		insulin like growth factor binding protein 4	MX dynamin like GTPase 2
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen	Nucleus Nuclear Envelope Nuclear Pore Cytoplasm Cytosol Microtubule Plasma Membrane Synapse Presynapse
	Molecular Function	Signaling Receptor Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Microtubule Binding
	Biological Process	MAPK Cascade Regulation Of Cell Growth Signal Transduction Regulation Of Glucose Metabolic Process Regulation Of Growth Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway	Immune System Process Defense Response Response To Virus Protein Transport Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Response To Interferon-alpha Innate Immune Response Regulation Of Nucleocytoplasmic Transport MRNA Transport Defense Response To Virus Regulation Of Cell Cycle
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	ISG15 antiviral mechanism Interferon alpha/beta signaling
GWAS		Height ( 23563607 31562340 ) Pancreatic cancer ( 29422604 ) Pancreatic ductal adenocarcinoma ( 30541042 )	Cutaneous malignant melanoma ( 32341527 ) Melanoma ( 21983787 28212542 ) Nevus count or cutaneous melanoma ( 30429480 32341527 ) Parkinson disease and lewy body pathology ( 25663231 ) Tau burden ( 33426524 )
Novel Interactors		1 novel interactors: MX2	6 novel interactors: IGFBP4 LSS MX1 NDUFV3 PKNOX1 STK38L
Interacting Genes		9 interacting genes: CTSD HK3 IGF1 IGF2 KDM1A MEX3A PAPPA SUV39H1 TF	3 interacting genes: ATRIP EHMT2 PIAS2
Entrez ID		3487	4600
HPRD ID		00900	01001
Ensembl ID		ENSG00000141753	ENSG00000183486
Uniprot IDs		P22692	P20592
PDB IDs		1WQJ 2DSP 2DSQ 2DSR	4WHJ 4X0R 5UOT
GO Terms Enriched among Interactors		Exocrine Pancreas Development Insulin-like Growth Factor Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Positive Regulation Of Glycogen Biosynthetic Process Insulin Receptor Binding Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Regulation Of Glycogen Biosynthetic Process Epigenetic Programming Of Gene Expression Regulation Of Glycogen Metabolic Process Regulation Of Activated T Cell Proliferation Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Organ Growth Extracellular Region Positive Regulation Of Neural Precursor Cell Proliferation Epigenetic Regulation Of Gene Expression Negative Regulation Of Oocyte Development Platelet Alpha Granule Lumen Regulation Of Multicellular Organism Growth Regulation Of Developmental Growth Striated Muscle Cell Differentiation Aspartic-type Peptidase Activity Endopeptidase Activity Extracellular Space Intracellular Glucose Homeostasis Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Trophectodermal Cell Proliferation Epithelial To Mesenchymal Transition Insulin Receptor Signaling Pathway Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Regulation Of Organ Growth Regulation Of Neural Precursor Cell Proliferation Mannokinase Activity Insulin-like Growth Factor Binding Protein Complex Positive Regulation Of T Cell Proliferation Muscle Cell Development Glycolate Metabolic Process Regulation Of Glucose Metabolic Process Muscle Cell Differentiation Mesenchymal Cell Differentiation ENoSc Complex Iron Chaperone Activity Iron Ion Export Across Plasma Membrane Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Ficolin-1-rich Granule Lumen Insulin Catabolic Process Insulin Receptor Recycling	None