LRAT

Description		lecithin retinol acyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Multivesicular Body Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Retinoic Acid Binding Protein Binding O-acyltransferase Activity O-palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Retinol Binding Phosphatidylcholine-retinol O-acyltransferase Activity
	Biological Process	Retinoid Metabolic Process Lipid Metabolic Process Vitamin A Metabolic Process Visual Perception Response To Bacterium Lipid Storage Positive Regulation Of Lipid Transport Response To Retinoic Acid Response To Vitamin A Retinol Metabolic Process Cellular Response To Leukemia Inhibitory Factor
Pathways		The canonical retinoid cycle in rods (twilight vision) Retinoid metabolism and transport Defective visual phototransduction due to LRAT loss of function
Drugs		Vitamin A
Diseases		Leber congenital amaurosis (LCR) Retinitis pigmentosa (RP)
GWAS		Activated partial thromboplastin time ( 29403010) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		6 interacting genes: BLCAP HSD17B13 RBP1 RBP2 TMEM31 TMX2
Entrez ID		9227
HPRD ID		05332
Ensembl ID		ENSG00000121207
Uniprot IDs		O95237
PDB IDs
Enriched GO Terms of Interacting Partners?		Retinal Binding Vitamin A Metabolic Process Retinoid Binding Retinol Binding Fatty Acid Binding Diterpenoid Metabolic Process Retinoid Metabolic Process Terpenoid Metabolic Process Fatty Acid Transport Lipid Droplet Isoprenoid Metabolic Process Monocarboxylic Acid Transport All-trans-retinol Binding Steroid Dehydrogenase Activity Apoptotic Nuclear Changes Retinoic Acid Biosynthetic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Carboxylic Acid Transport Organic Acid Transport Disulfide Oxidoreductase Activity Molecular Carrier Activity Lipid Metabolic Process Lipid Transport Lipid Binding Organic Anion Transport Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity All-trans-retinol Dehydrogenase (NAD+) Activity Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Isoprenoid Biosynthetic Process Retinoic Acid Metabolic Process
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