LRAT and BLCAP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LRAT	BLCAP
Description		lecithin retinol acyltransferase	BLCAP apoptosis inducing factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Multivesicular Body Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Membrane
	Molecular Function	Retinoic Acid Binding Protein Binding O-acyltransferase Activity O-palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Retinol Binding Phosphatidylcholine-retinol O-acyltransferase Activity	Protein Binding
	Biological Process	Retinoid Metabolic Process Lipid Metabolic Process Vitamin A Metabolic Process Visual Perception Response To Bacterium Lipid Storage Positive Regulation Of Lipid Transport Response To Retinoic Acid Response To Vitamin A Retinol Metabolic Process Cellular Response To Leukemia Inhibitory Factor	Apoptotic Process Apoptotic Nuclear Changes
Pathways		The canonical retinoid cycle in rods (twilight vision) Retinoid metabolism and transport Defective visual phototransduction due to LRAT loss of function
Drugs		Vitamin A
Diseases		Leber congenital amaurosis (LCR) Retinitis pigmentosa (RP)
GWAS		Activated partial thromboplastin time ( 29403010) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)	Rheumatoid arthritis ( 30891314)
Interacting Genes		6 interacting genes: BLCAP HSD17B13 RBP1 RBP2 TMEM31 TMX2	17 interacting genes: ASGR1 CLDND2 CYSRT1 FAM241B GIMAP1 GJA5 GOSR2 HOXA1 LEMD1 LRAT NOTCH2NLA SKAP1 SLC61A1 SSMEM1 TMEM14B TMEM237 TMEM31
Entrez ID		9227	10904
HPRD ID		05332	16552
Ensembl ID		ENSG00000121207	ENSG00000166619
Uniprot IDs		O95237	P62952
PDB IDs
Enriched GO Terms of Interacting Partners?		Retinal Binding Vitamin A Metabolic Process Retinoid Binding Retinol Binding Fatty Acid Binding Diterpenoid Metabolic Process Retinoid Metabolic Process Terpenoid Metabolic Process Fatty Acid Transport Lipid Droplet Isoprenoid Metabolic Process Monocarboxylic Acid Transport All-trans-retinol Binding Steroid Dehydrogenase Activity Apoptotic Nuclear Changes Retinoic Acid Biosynthetic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Carboxylic Acid Transport Organic Acid Transport Disulfide Oxidoreductase Activity Molecular Carrier Activity Lipid Metabolic Process Lipid Transport Lipid Binding Organic Anion Transport Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity All-trans-retinol Dehydrogenase (NAD+) Activity Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Isoprenoid Biosynthetic Process Retinoic Acid Metabolic Process	Membrane Gap Junction Channel Activity Involved In Purkinje Myocyte-ventricular Cardiac Muscle Cell Electrical Coupling Mitral Valve Development Septum Primum Development Gap Junction Channel Activity Involved In Atrial Cardiac Muscle Cell-AV Node Cell Electrical Coupling Atrial Ventricular Junction Remodeling Gap Junction Channel Activity Involved In Bundle Of His Cell-Purkinje Myocyte Electrical Coupling Positive Regulation Of Cell Communication By Chemical Coupling Atrial Cardiac Muscle Cell To AV Node Cell Communication By Electrical Coupling Vasomotion Purkinje Myocyte To Ventricular Cardiac Muscle Cell Communication By Electrical Coupling Regulation Of Purkinje Myocyte Action Potential Semicircular Canal Formation O-palmitoyltransferase Activity Phosphatidylcholine-retinol O-acyltransferase Activity Molybdate Ion Transmembrane Transporter Activity Molybdate Ion Transport Asialoglycoprotein Receptor Activity Gap Junction Channel Activity Involved In SA Node Cell-atrial Cardiac Muscle Cell Electrical Coupling Artery Morphogenesis Foramen Ovale Closure Bundle Of His Cell To Purkinje Myocyte Communication By Electrical Coupling Regulation Of Bundle Of His Cell Action Potential Cell Communication By Chemical Coupling Pulmonary Valve Formation SA Node Cell To Atrial Cardiac Muscle Cell Communication By Electrical Coupling Atrial Cardiac Muscle Cell To AV Node Cell Communication Abducens Nerve Formation Optokinetic Behavior Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Renin Secretion Into Blood Stream Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Regulation Of AV Node Cell Action Potential Cerebral Cortex Development Regulation Of Atrial Cardiac Muscle Cell Action Potential Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling SA Node Cell To Atrial Cardiac Muscle Cell Communication Negative Regulation Of Glomerular Filtration AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling
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