SLC10A6 and SACM1L

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC10A6	SACM1L
Description		solute carrier family 10 member 6	SAC1 like phosphatidylinositide phosphatase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane AMPA Glutamate Receptor Complex Glutamatergic Synapse Endoplasmic Reticulum-plasma Membrane Contact Site
	Molecular Function	Protein Binding Bile Acid:sodium Symporter Activity Symporter Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity	Phosphatidylinositol-3-phosphate Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Phosphatidylinositol-4-phosphate Phosphatase Activity
	Biological Process	Monoatomic Ion Transport Sodium Ion Transport Lipid Transport Bile Acid And Bile Salt Transport Sodium-dependent Organic Anion Transport Transmembrane Transport	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphatidylinositol Dephosphorylation Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Vesicle-mediated Transport In Synapse
Pathways		SLC-mediated bile acid transport	Synthesis of PIPs at the ER membrane Synthesis of PIPs at the Golgi membrane
Drugs
Diseases
GWAS		Eyebrow thickness ( 26926045) Insulin-related traits ( 22791750) Refractive error ( 32231278)	Acne (severe) ( 24927181) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Macular telangiectasia type 2 ( 33654266) Response to anti-depressant treatment in major depressive disorder ( 22041458) Serum metabolite levels ( 33031748) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		175 interacting genes: ACSL5 AGPAT4 AIG1 ANKRD46 APOD ARL6IP1 ARLN ARV1 ATP13A1 BMP10 BTN2A2 C11orf24 C14orf180 C2CD2L C3orf52 CATSPERH CCDC167 CCL4 CDIPT CDS1 CFTR CLDND2 CMTM5 CNIH1 COL4A5 COMT COX20 CTSA CXCL16 CYB5B CYB5R3 CYP4F2 DERL1 DGAT2L6 EBP EMC6 ERG28 FA2H FAM3C FAXDC2 FIS1 FKBP8 FMO1 FUNDC2 FXYD3 FXYD6 FXYD6-FXYD2 GIMAP1 GIMAP5 GJB2 GJB6 GLB1 GOLT1B GOSR2 GPR151 GYPA GYPC HMOX1 HTATIP2 IGFBP5 ITGAM JAGN1 LPAR3 LSS MALL MFSD6 MGLL MS4A1 MS4A13 NAT8 NEU1 NINJ2 NRM OR7D4 ORMDL1 OSMR PEDS1-UBE2V1 PEX16 PIP4P1 PIP4P2 PLLP PLP1 PLP2 PNLIPRP1 PRAF2 PRRT2 PSEN1 PSENEN RNF24 RTP2 RUSF1 SACM1L SCAMP4 SCAMP5 SCD SEC22B SELENOK SERP1 SERP2 SFT2D2 SFXN1 SLC12A7 SLC25A46 SLC29A2 SLC30A2 SLC30A3 SLC35B4 SLC35G2 SLC35H1 SLC38A1 SLC38A7 SLC39A6 SLC39A9 SLC41A1 SLC61A1 SLC66A2 SLC7A1 SMAGP SMCO4 SMIM1 SNORC STATH STX12 STX3 STX7 STX8 SYNGR1 SYNJ2BP TAP1 TECR TF THBD TM4SF4 TMEM107 TMEM11 TMEM119 TMEM120B TMEM128 TMEM143 TMEM14A TMEM14B TMEM14C TMEM203 TMEM208 TMEM218 TMEM222 TMEM229B TMEM234 TMEM239 TMEM242 TMEM243 TMEM252 TMEM50B TMEM60 TMEM65 TMEM86A TMEM86B TPRG1 TRARG1 TREX1 TSNARE1 TSPAN2 TSPO2 TVP23B UBE2J1 UBIAD1 UNC50 VAMP1 VAMP3 VAMP4 YIPF1 YIPF2 YIPF6 ZDHHC15 ZFPL1	36 interacting genes: ACKR2 AQP6 ARL13B CD79A COPA COPB2 COPG1 CREB3 CREB3L1 DHRS7 EBP FAM209A FFAR2 FMO3 GPR151 GPR152 HSD17B13 JAGN1 LMNA MFF MTERF2 ODF4 PRKCA RNF19B RTN3 SCN3B SLC10A1 SLC10A6 SLC35A5 SLC35H1 SLC71A2 SLC7A1 TMEM167B TMX2 VEZT ZFYVE27
Entrez ID		345274	22908
HPRD ID		11593	07587
Ensembl ID		ENSG00000145283	ENSG00000211456
Uniprot IDs		Q3KNW5	A0A5F9ZHN7 A0A9L9PXJ6 B4DVV3 E9PGZ4 Q9NTJ5
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity Endomembrane System Protein Binding SNARE Complex Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Sterol Biosynthetic Process Lipid Metabolic Process Lipid Biosynthetic Process Membrane Fusion Establishment Of Protein Localization Membrane Organization Vesicle Docking Membrane Docking Vesicle-mediated Transport Golgi Membrane Mitochondrial Outer Membrane Plasma Membrane Organelle Localization By Membrane Tethering Golgi Apparatus Cholesterol Biosynthetic Process Transmembrane Transport Steroid Biosynthetic Process Amino Acid Transmembrane Transport Chloride Channel Inhibitor Activity Sterol Metabolic Process SNARE Binding Golgi Trans Cisterna Synaptic Vesicle Membrane Zinc Ion Transmembrane Transporter Activity Golgi Medial Cisterna Transport Vesicle Vesicle Organization Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Phosphatidylinositol-4,5-bisphosphate 4-phosphatase Activity Alkenylglycerophosphocholine Hydrolase Activity Protein Transport Intracellular Chemical Homeostasis Structural Constituent Of Myelin Sheath Zinc Ion Transmembrane Transport Cellular Localization Zinc Ion Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Intracellular Transport Chemical Homeostasis Small Molecule Biosynthetic Process	Membrane Endoplasmic Reticulum Membrane COPI Vesicle Coat COPI-coated Vesicle Membrane Endoplasmic Reticulum Membrane Coat Intra-Golgi Vesicle-mediated Transport Bile Acid:sodium Symporter Activity Endoplasmic Reticulum Tubular Network Formation Pyrimidine Nucleotide-sugar Transmembrane Transport Nucleotide-sugar Transmembrane Transport Endoplasmic Reticulum Organization Golgi Membrane Structural Molecule Activity Sodium Ion Transport Bile Acid And Bile Salt Transport Endoplasmic Reticulum Tubular Network Organization Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
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