SLC10A6 and PSENEN

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC10A6	PSENEN
Description		solute carrier family 10 member 6	presenilin enhancer, gamma-secretase subunit
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Endosome Membrane Membrane Golgi Cisterna Membrane Presynaptic Membrane Gamma-secretase Complex
	Molecular Function	Protein Binding Bile Acid:sodium Symporter Activity Symporter Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity	Protein Binding Enzyme Binding Endopeptidase Activator Activity
	Biological Process	Monoatomic Ion Transport Sodium Ion Transport Lipid Transport Bile Acid And Bile Salt Transport Sodium-dependent Organic Anion Transport Transmembrane Transport	Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Positive Regulation Of Endopeptidase Activity Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Amyloid Precursor Protein Metabolic Process Amyloid Precursor Protein Catabolic Process
Pathways		SLC-mediated bile acid transport	Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation TGFBR3 PTM regulation
Drugs			E-2012
Diseases			Acne inversa; Hidradenitis supprativa
GWAS		Eyebrow thickness ( 26926045) Insulin-related traits ( 22791750) Refractive error ( 32231278)	Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278)
Interacting Genes		175 interacting genes: ACSL5 AGPAT4 AIG1 ANKRD46 APOD ARL6IP1 ARLN ARV1 ATP13A1 BMP10 BTN2A2 C11orf24 C14orf180 C2CD2L C3orf52 CATSPERH CCDC167 CCL4 CDIPT CDS1 CFTR CLDND2 CMTM5 CNIH1 COL4A5 COMT COX20 CTSA CXCL16 CYB5B CYB5R3 CYP4F2 DERL1 DGAT2L6 EBP EMC6 ERG28 FA2H FAM3C FAXDC2 FIS1 FKBP8 FMO1 FUNDC2 FXYD3 FXYD6 FXYD6-FXYD2 GIMAP1 GIMAP5 GJB2 GJB6 GLB1 GOLT1B GOSR2 GPR151 GYPA GYPC HMOX1 HTATIP2 IGFBP5 ITGAM JAGN1 LPAR3 LSS MALL MFSD6 MGLL MS4A1 MS4A13 NAT8 NEU1 NINJ2 NRM OR7D4 ORMDL1 OSMR PEDS1-UBE2V1 PEX16 PIP4P1 PIP4P2 PLLP PLP1 PLP2 PNLIPRP1 PRAF2 PRRT2 PSEN1 PSENEN RNF24 RTP2 RUSF1 SACM1L SCAMP4 SCAMP5 SCD SEC22B SELENOK SERP1 SERP2 SFT2D2 SFXN1 SLC12A7 SLC25A46 SLC29A2 SLC30A2 SLC30A3 SLC35B4 SLC35G2 SLC35H1 SLC38A1 SLC38A7 SLC39A6 SLC39A9 SLC41A1 SLC61A1 SLC66A2 SLC7A1 SMAGP SMCO4 SMIM1 SNORC STATH STX12 STX3 STX7 STX8 SYNGR1 SYNJ2BP TAP1 TECR TF THBD TM4SF4 TMEM107 TMEM11 TMEM119 TMEM120B TMEM128 TMEM143 TMEM14A TMEM14B TMEM14C TMEM203 TMEM208 TMEM218 TMEM222 TMEM229B TMEM234 TMEM239 TMEM242 TMEM243 TMEM252 TMEM50B TMEM60 TMEM65 TMEM86A TMEM86B TPRG1 TRARG1 TREX1 TSNARE1 TSPAN2 TSPO2 TVP23B UBE2J1 UBIAD1 UNC50 VAMP1 VAMP3 VAMP4 YIPF1 YIPF2 YIPF6 ZDHHC15 ZFPL1	10 interacting genes: APH1A CRB3 CREB3 NCSTN PSEN1 PSEN2 SLC10A2 SLC10A6 THBD TMED10
Entrez ID		345274	55851
HPRD ID		11593	06362
Ensembl ID		ENSG00000145283	ENSG00000205155
Uniprot IDs		Q3KNW5	Q9NZ42
PDB IDs			5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC 6LQG 6LR4 7C9I 7D8X 7Y5T 7Y5X 7Y5Z 8IM7 8K8E 8KCO 8KCP 8KCS 8KCT 8KCU 8OQY 8OQZ 8X52 8X53 8X54
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity Endomembrane System Protein Binding SNARE Complex Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Sterol Biosynthetic Process Lipid Metabolic Process Lipid Biosynthetic Process Membrane Fusion Establishment Of Protein Localization Membrane Organization Vesicle Docking Membrane Docking Vesicle-mediated Transport Golgi Membrane Mitochondrial Outer Membrane Plasma Membrane Organelle Localization By Membrane Tethering Golgi Apparatus Cholesterol Biosynthetic Process Transmembrane Transport Steroid Biosynthetic Process Amino Acid Transmembrane Transport Chloride Channel Inhibitor Activity Sterol Metabolic Process SNARE Binding Golgi Trans Cisterna Synaptic Vesicle Membrane Zinc Ion Transmembrane Transporter Activity Golgi Medial Cisterna Transport Vesicle Vesicle Organization Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Phosphatidylinositol-4,5-bisphosphate 4-phosphatase Activity Alkenylglycerophosphocholine Hydrolase Activity Protein Transport Intracellular Chemical Homeostasis Structural Constituent Of Myelin Sheath Zinc Ion Transmembrane Transport Cellular Localization Zinc Ion Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Intracellular Transport Chemical Homeostasis Small Molecule Biosynthetic Process	Gamma-secretase Complex Notch Receptor Processing Amyloid-beta Formation Amyloid Precursor Protein Catabolic Process Membrane Protein Ectodomain Proteolysis Amyloid-beta Metabolic Process Amyloid Precursor Protein Metabolic Process Aspartic Endopeptidase Activity, Intramembrane Cleaving Membrane Protein Proteolysis Protein Processing Synaptic Membrane Notch Signaling Pathway Protein Maturation Golgi Membrane Presynaptic Membrane Synaptic Vesicle Growth Factor Receptor Binding Bile Acid:sodium Symporter Activity Endoplasmic Reticulum Membrane Early Endosome Membrane Protein Intracellular Domain Proteolysis Golgi Apparatus Vesicle Targeting Plasma Membrane Endopeptidase Activator Activity Bile Acid And Bile Salt Transport Endoplasmic Reticulum Membrane Positive Regulation Of Coagulation Proteolysis Azurophil Granule Membrane Carboxylic Acid Transport Organic Acid Transport Cerebellum Development Negative Regulation Of Core Promoter Binding Positive Regulation Of Deacetylase Activity Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Amyloid Precursor Protein Biosynthetic Process Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Protein-containing Complex Organic Anion Transport ATPase Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Endopeptidase Activity Cajal-Retzius Cell Differentiation Blood Coagulation, Common Pathway Symporter Activity
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