PAX2 and WT1

Number of citations of the paper that reports this interaction (PMID 14603255)
8

Data Source:
HPRD (in vitro, in vivo)

		PAX2	WT1
Gene Name		paired box 2	Wilms tumor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Lysosome Microtubule Organizing Center Protein-DNA Complex Centriolar Satellite Protein Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Nuclear Speck
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Core Promoter Proximal Region Sequence-specific DNA Binding DNA Binding Protein Binding Transcription Factor Binding Superoxide-generating NADPH Oxidase Activity Transcription Regulatory Region DNA Binding C2H2 Zinc Finger Domain Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding C2H2 Zinc Finger Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Urogenital System Development Branching Involved In Ureteric Bud Morphogenesis Cell Fate Determination Mesonephros Development Neural Tube Closure Optic Cup Morphogenesis Involved In Camera-type Eye Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Retinal Pigment Epithelium Development Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Axonogenesis Mesodermal Cell Fate Specification Aging Visual Perception Glial Cell Differentiation Optic Nerve Development Optic Nerve Morphogenesis Optic Nerve Structural Organization Vestibulocochlear Nerve Formation Pancreas Development Response To Nutrient Levels Regulation Of Metanephros Size Ureter Maturation Pronephric Field Specification Inner Ear Morphogenesis Camera-type Eye Development Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Kinase B Signaling Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cytolysis Positive Regulation Of Transcription From RNA Polymerase II Promoter Pronephros Development Brain Morphogenesis Stem Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Oxidation-reduction Process Mesenchymal To Epithelial Transition Paramesonephric Duct Development Optic Chiasma Development Cellular Response To Hydrogen Peroxide Cellular Response To Mechanical Stimulus Cellular Response To Retinoic Acid Cellular Response To Glucose Stimulus Cellular Response To Epidermal Growth Factor Stimulus Metanephric Mesenchyme Development Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Metanephric Mesenchymal Cell Differentiation Mesonephric Tubule Formation Mesonephric Duct Development Nephric Duct Formation Ureter Development Ureter Morphogenesis Metanephric Collecting Duct Development Metanephric Epithelium Development Metanephric Distal Convoluted Tubule Development Metanephric Nephron Tubule Formation Positive Regulation Of Metanephric Glomerulus Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Reactive Oxygen Species Metabolic Process Cochlea Development Cochlea Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Metanephric DCT Cell Differentiation Positive Regulation Of Optic Nerve Formation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Vasculogenesis Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Regulation Of Organ Formation Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Germ Cell Development Thorax And Anterior Abdomen Determination Heart Development Sex Determination Negative Regulation Of Cell Proliferation RNA Splicing Gonad Development Male Gonad Development Tissue Development Negative Regulation Of Translation Negative Regulation Of Cell Growth Adrenal Gland Development Male Genitalia Development Epithelial Cell Differentiation Glomerulus Development Glomerular Basement Membrane Development Adrenal Cortex Formation Camera-type Eye Development Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Mesenchymal To Epithelial Transition Positive Regulation Of Heart Growth Diaphragm Development Cardiac Muscle Cell Fate Commitment Visceral Serous Pericardium Development Cellular Response To CAMP Cellular Response To Gonadotropin Stimulus Metanephric Mesenchyme Development Glomerular Visceral Epithelial Cell Differentiation Posterior Mesonephric Tubule Development Metanephric Epithelium Development Metanephric S-shaped Body Morphogenesis Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development Positive Regulation Of Metanephric Ureteric Bud Development
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease ( 20061627)	Tuberculosis ( 22306650)
Protein-Protein Interactions		11 interactors: BBS1 BBS2 BBS4 BBS7 ID2 MAPK8 MAPK8IP1 PAXIP1 RB1 SFRP2 WT1	23 interactors: AREG CIAO1 CREBBP DVL3 EGR1 FHL2 KRT40 KRTAP10-3 KRTAP10-8 MDM2 NPM3 PAWR PAX2 PRKACA TAOK1 TP53 TP63 TP73 U2AF2 UBE2I WTAP WTIP ZNF205
Entrez ID		5076	7490
HPRD ID		01330	06163
Ensembl ID		ENSG00000075891	ENSG00000184937
Uniprot IDs		Q02962	P19544 Q6PI38
PDB IDs			1LU6 1XF7 2G7T 2G7V 2G7W 2G7X 2JP9 2JPA 2PRT 3HPJ 3MYJ
Enriched GO Terms of Interacting Partners?		Nonmotile Primary Cilium Assembly Anatomical Structure Morphogenesis Tissue Development Tube Development Digestive Tract Development Photoreceptor Cell Maintenance Melanosome Transport Digestive System Development Pigment Granule Transport Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Establishment Of Melanosome Localization Cilium Assembly Melanosome Localization Tube Morphogenesis Visual Perception Sensory Perception Of Light Stimulus Cardiovascular System Development Cilium Organization Regulation Of Gene Expression JUN Phosphorylation Cilium Morphogenesis Heart Development Organ Morphogenesis Positive Regulation Of Growth Heart Morphogenesis Retina Homeostasis Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Cellular Pigmentation Anatomical Structure Formation Involved In Morphogenesis Cell Morphogenesis Connective Tissue Development Digestive Tract Morphogenesis Leptin-mediated Signaling Pathway Cell Projection Assembly Regulation Of Cellular Protein Metabolic Process Regulation Of Developmental Growth Organ Development Negative Regulation Of Appetite Response To Stimulus Negative Regulation Of Gene Expression Establishment Of Organelle Localization Positive Regulation Of Macrophage Differentiation Cellular Response To Leptin Stimulus Regulation Of Protein Metabolic Process Negative Regulation Of JUN Kinase Activity Regulation Of Microtubule-based Movement Pigmentation Cell Differentiation Epithelial Tube Morphogenesis Striatum Development	Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Radiation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Cellular Response To Light Stimulus Regulation Of Gene Expression Regulation Of Signal Transduction Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Apoptotic Process Regulation Of Cell Proliferation Response To Gamma Radiation Response To Abiotic Stimulus Regulation Of Signaling Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cell Death DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator RNA Metabolic Process DNA Damage Checkpoint Cellular Response To UV DNA Damage Response, Signal Transduction Resulting In Transcription Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Nucleic Acid-templated Transcription Apoptotic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Death Programmed Cell Death Signal Transduction In Response To DNA Damage Cell Death Death Mitotic DNA Damage Checkpoint
Tagcloud ?		agarose childhood concomitantly electrophoretically elucidation embryonal exception films gels heterotransplant hybridized intensifying neoplasm nonrenal nude nylon paired pax8 primer propagated resembling screens segments transferred wilms wt wt1 wts	al antisense discovery enhance et evidence genomic humans igf2r imprinted imprinting issue locus might moorwood murine particularly recent regulating relate rna since suppressor transcript transcripts tumour typically unusual wilms
Tagcloud (Difference) ?		agarose childhood concomitantly electrophoretically elucidation embryonal exception films gels heterotransplant hybridized intensifying neoplasm nonrenal nude nylon paired pax8 primer propagated resembling screens segments transferred wt wts	al antisense discovery enhance et evidence genomic humans igf2r imprinted imprinting issue locus might moorwood murine particularly recent regulating relate rna since suppressor transcript transcripts tumour typically unusual
Tagcloud (Intersection) ?		wilms wt1