ARL16 and TCF12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARL16	TCF12
Description		ARF like GTPase 16	transcription factor 12
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Speck RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding CAMP Response Element Binding BHLH Transcription Factor Binding SMAD Binding Protein Heterodimerization Activity Protein Dimerization Activity E-box Binding HMG Box Domain Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process		Regulation Of Transcription By RNA Polymerase II Immune Response Nervous System Development Muscle Organ Development Gene Expression Positive Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Gonadotropin-releasing Hormone
Pathways			Myogenesis Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs NGF-stimulated transcription NGF-stimulated transcription Negative Regulation of CDH1 Gene Transcription TGFBR3 expression
Drugs
Diseases
GWAS		Refractive error ( 32231278)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein B levels ( 32203549) Body mass index ( 28892062) Glaucoma (primary open-angle) ( 29891935 33627673) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Male-pattern baldness ( 28196072) Mean platelet volume ( 27863252 32888494) Triglyceride levels ( 32154731) Type 2 diabetes ( 30297969)
Interacting Genes		8 interacting genes: AMPH DEUP1 GLYR1 GOLGA2 PDE6D REL TCF12 TCF4	68 interacting genes: AIRIM ARL16 ARMC8 ASCL4 BMERB1 BMF CDKN2C CFAP206 CKS1B CLCNKA CRCP CREBBP DDX6 DGCR6 EDRF1 EP300 EXOC8 FRMD6 GRB7 HAND1 HOPX ID1 ID2 ID3 LAMTOR5 LNX1 LYSMD1 MAPKBP1 MLLT6 MORN4 MSC MYF6 MYO15B NAGK NEK6 NEUROD1 NEUROG1 NGLY1 NHLH2 OLIG3 OSGIN1 PIN1 PRKAB2 PRSS23 PSMA1 PTF1A QARS1 RBM8A RNASEL RUNX1T1 SOX10 SOX8 SPG21 SRI STAT5A STK16 TAF4 TAL2 TBC1D21 TBP TCF21 TCF3 TMEM132D TRIM72 TSNAX VPS28 WTAP ZNF688
Entrez ID		339231	6938
HPRD ID		19069	02725
Ensembl ID		ENSG00000214087	ENSG00000140262
Uniprot IDs		B4E3H0 I3L4Z7 Q0P5N6	F5GY10 Q99081
PDB IDs			2KNH 4JOL
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Biosynthetic Process Positive Regulation Of Protein Glycosylation Regulation Of Protein Glycosylation Microtubule Organizing Center Organization Positive Regulation Of Macromolecule Biosynthetic Process Golgi Disassembly Chromatin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity NF-kappaB Complex TFIIB-class Transcription Factor Binding Regulation Of Neuron Differentiation Protein Dimerization Activity Positive Regulation Of Neuron Differentiation Beta-catenin-TCF7L2 Complex E-box Binding Response To Gonadotropin-releasing Hormone Transcription Elongation-coupled Chromatin Remodeling De Novo Centriole Assembly Deuterosome De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation Multi-ciliated Epithelial Cell Differentiation	Protein Dimerization Activity Chromatin DNA-binding Transcription Factor Binding E-box Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Cell Fate Commitment Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Animal Organ Development Regulation Of Macromolecule Biosynthetic Process Neuron Differentiation BHLH Transcription Factor Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Histone H3K27 Acetyltransferase Activity Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Biosynthetic Process Nucleus Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex Striated Muscle Tissue Development Transcription Regulator Inhibitor Activity Nucleoplasm Regulation Of Macromolecule Metabolic Process Tau Protein Binding Oligodendrocyte Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Thigmotaxis Branchiomeric Skeletal Muscle Development Muscle Tissue Development Cytoplasm Negative Regulation Of Macromolecule Biosynthetic Process Cell Differentiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Developmental Process
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