KRTAP6-3 and TBX2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRTAP6-3	TBX2
Description		keratin associated protein 6-3	T-box transcription factor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Keratinization	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Heart Looping Heart Morphogenesis Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Endocardial Cushion Morphogenesis Endocardial Cushion Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Notch Signaling Pathway Muscle Cell Fate Determination Regulation Of Heart Contraction Fibroblast Growth Factor Receptor Signaling Pathway Neurogenesis Response To Retinoic Acid Embryonic Heart Tube Development Aorta Morphogenesis Atrioventricular Canal Development Embryonic Digit Morphogenesis Pigment Metabolic Process Involved In Pigmentation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Camera-type Eye Morphogenesis Cardiac Muscle Tissue Development Smooth Muscle Cell Differentiation Roof Of Mouth Development Pharyngeal System Development Positive Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Cell Myoblast Differentiation Epithelial Tube Branching Involved In Lung Morphogenesis Developmental Growth Involved In Morphogenesis Mammary Placode Formation Mesenchymal Cell Proliferation Involved In Lung Development Cellular Response To Dexamethasone Stimulus Ureteric Peristalsis Cochlea Morphogenesis Cellular Senescence Melanocyte Proliferation Negative Regulation Of Heart Looping Negative Regulation Of Cardiac Chamber Formation Positive Regulation Of Cell Cycle G1/S Phase Transition Cardiac Jelly Development Atrioventricular Canal Morphogenesis Negative Regulation Of Cellular Senescence
Pathways			Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Drugs
Diseases
GWAS			Age-related hearing impairment ( 34108613) Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Chloride levels ( 29403010) Chronic kidney disease ( 20383146) Circulating fibroblast growth factor 23 levels ( 30217807) Corneal hysteresis ( 32716492) Corneal resistance factor ( 32716492) Coronary artery disease ( 29212778) Creatinine levels ( 31015462 20383145) Diastolic blood pressure ( 30487518 27618448 27618447 27841878) Estimated glomerular filtration rate ( 31015462) Height ( 19893584 18391951 20881960) Hypertension ( 30487518 27618447) Kidney volume ( 34128465) Mean arterial pressure ( 27618448 30487518 26390057) Potassium levels ( 29403010) Pulse pressure ( 27841878 27618447) Refractive error ( 32231278) Sitting height ratio ( 25865494) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Systolic blood pressure ( 30487518 28739976 27618447 27618448 27841878) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		160 interacting genes: ADAMTSL4 AGXT ARID5A ARMC7 ATOSB ATPAF2 AUTS2 BAG4 BEX2 BSCL2 C11orf87 CAMK2A CAMK2B CAMK2G CARHSP1 CCDC120 CCDC24 CCER1 CELF5 CHRD CLCNKA CNNM3 COL8A1 CREB5 CRY2 CTSZ CYSRT1 DALRD3 DHRS1 DMRT3 FADS6 FAM83A FBXW5 FCHO1 FOXD2 FOXD4L1 GATA2 GATA3 GLYCTK GNE GPS2 HAPLN2 HHEX HOXA1 HOXB5 HOXB9 HOXC8 HR HYAL2 ILF2 INCA1 INPP5D ITGB4 KANK2 KPRP KRT20 KRTAP11-1 KRTAP12-2 KRTAP19-2 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP26-1 KRTAP4-4 KRTAP6-1 KRTAP6-2 LAGE3 LCE1A LCE1B LCE1C LCE1E LCE1F LCE2A LCE2B LCE2C LCE3A LCE3C LCE3D LCE3E LCE5A LGALS9 LNX1 MAGED1 MAPK1IP1L MAPKBP1 MBD3L2 MED25 MEIS2 MEOX2 MGAT5B NODAL NOTO NR4A3 OLIG3 OTX1 OXER1 P4HB PATZ1 PCDHB14 PGAP6 PHETA1 PHLDA1 PIGS PITX1 PLSCR4 POU4F2 POU4F3 PPP1R37 PRMT8 PROP1 PRPF31 PRR13 PRR3 PRR35 PSMA1 PVR RAB3IL1 RAD54L2 RASD1 RHBDL1 RUNX1T1 SAMD7 SAXO4 SAXO5 SEMA4C SH3KBP1 SLC15A2 SLC22A5 SMARCC1 SMARCE1 SMCP SNRPB SNRPC SNX18 STK16 STRA6 TAOK2 TBX2 TBX6 TCAF1 TCF7L2 TEKT4 TENT2 TFAP2D TLE5 TLX3 TNIP1 TNS2 TSPYL6 TYK2 VASN VENTX VSTM4 WDR25 ZBTB32 ZIC1 ZNF414 ZNF497 ZNF575 ZNF79	12 interacting genes: ATXN1L CEBPE CIDEB CNOT2 CYSRT1 KRTAP6-3 LMO2 LZTR1 MEIS2 NKX2-5 TNPO2 TTC19
Entrez ID		337968	6909
HPRD ID		11220	02850
Ensembl ID		ENSG00000212938	ENSG00000121068
Uniprot IDs			Q13207
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Keratinization Epidermis Development Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Chromatin Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Tissue Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Intermediate Filament Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription DNA Binding Developmental Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Calcium- And Calmodulin-dependent Protein Kinase Complex Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Inner Ear Morphogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process System Development Transcription Regulator Complex Pattern Specification Process Cell Fate Specification Regulation Of Gene Expression Anatomical Structure Morphogenesis Embryonic Morphogenesis Regulation Of Primary Metabolic Process Embryonic Pattern Specification Myoblast Fate Commitment SnRNP Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
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