KRTAP6-3 and POU4F3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRTAP6-3	POU4F3
Description		keratin associated protein 6-3	POU class 4 homeobox 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Keratinization	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Visual Perception Sensory Perception Of Sound Vestibulocochlear Nerve Development Cell Differentiation Retinal Ganglion Cell Axon Guidance Inner Ear Morphogenesis Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Axon Extension Inner Ear Development Neuromuscular Process Controlling Balance Neuron Apoptotic Process Inner Ear Receptor Cell Differentiation
Pathways
Drugs
Diseases			Deafness, autosomal dominant
GWAS			PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		160 interacting genes: ADAMTSL4 AGXT ARID5A ARMC7 ATOSB ATPAF2 AUTS2 BAG4 BEX2 BSCL2 C11orf87 CAMK2A CAMK2B CAMK2G CARHSP1 CCDC120 CCDC24 CCER1 CELF5 CHRD CLCNKA CNNM3 COL8A1 CREB5 CRY2 CTSZ CYSRT1 DALRD3 DHRS1 DMRT3 FADS6 FAM83A FBXW5 FCHO1 FOXD2 FOXD4L1 GATA2 GATA3 GLYCTK GNE GPS2 HAPLN2 HHEX HOXA1 HOXB5 HOXB9 HOXC8 HR HYAL2 ILF2 INCA1 INPP5D ITGB4 KANK2 KPRP KRT20 KRTAP11-1 KRTAP12-2 KRTAP19-2 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP26-1 KRTAP4-4 KRTAP6-1 KRTAP6-2 LAGE3 LCE1A LCE1B LCE1C LCE1E LCE1F LCE2A LCE2B LCE2C LCE3A LCE3C LCE3D LCE3E LCE5A LGALS9 LNX1 MAGED1 MAPK1IP1L MAPKBP1 MBD3L2 MED25 MEIS2 MEOX2 MGAT5B NODAL NOTO NR4A3 OLIG3 OTX1 OXER1 P4HB PATZ1 PCDHB14 PGAP6 PHETA1 PHLDA1 PIGS PITX1 PLSCR4 POU4F2 POU4F3 PPP1R37 PRMT8 PROP1 PRPF31 PRR13 PRR3 PRR35 PSMA1 PVR RAB3IL1 RAD54L2 RASD1 RHBDL1 RUNX1T1 SAMD7 SAXO4 SAXO5 SEMA4C SH3KBP1 SLC15A2 SLC22A5 SMARCC1 SMARCE1 SMCP SNRPB SNRPC SNX18 STK16 STRA6 TAOK2 TBX2 TBX6 TCAF1 TCF7L2 TEKT4 TENT2 TFAP2D TLE5 TLX3 TNIP1 TNS2 TSPYL6 TYK2 VASN VENTX VSTM4 WDR25 ZBTB32 ZIC1 ZNF414 ZNF497 ZNF575 ZNF79	7 interacting genes: AURKA DUSP21 GOLGA2 KRT31 KRTAP6-3 NHLRC4 PLA2G10
Entrez ID		337968	5459
HPRD ID		11220	03911
Ensembl ID		ENSG00000212938	ENSG00000091010
Uniprot IDs			Q15319
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Keratinization Epidermis Development Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Chromatin Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Tissue Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Intermediate Filament Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription DNA Binding Developmental Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Calcium- And Calmodulin-dependent Protein Kinase Complex Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Inner Ear Morphogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process System Development Transcription Regulator Complex Pattern Specification Process Cell Fate Specification Regulation Of Gene Expression Anatomical Structure Morphogenesis Embryonic Morphogenesis Regulation Of Primary Metabolic Process Embryonic Pattern Specification Myoblast Fate Commitment SnRNP Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway	Meiotic Spindle Assembly Meiotic Spindle Organization Negative Regulation Of Protein Binding Regulation Of Protein Binding Centrosome Cycle Mitotic Spindle Organization Organelle Disassembly Microtubule Organizing Center Organization Spindle Assembly Positive Regulation Of Reproductive Process Platelet Activating Factor Catabolic Process Reproductive Process Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Oocyte Maturation Lysophospholipid Transport Positive Regulation Of Protein Glycosylation Mitotic Spindle Spindle Pole Cytoskeleton Intermediate Filament Spindle Assembly Involved In Female Meiosis I Germinal Vesicle Histone H3S10 Kinase Activity Spindle Organization Golgi Disassembly Regulation Of Reproductive Process Chromosome Passenger Complex Mitotic Centrosome Separation Regulation Of Arachidonate Secretion Intestinal Stem Cell Homeostasis Positive Regulation Of Arachidonate Secretion Regulation Of Protein Glycosylation Pronucleus Axon Hillock 1-alkyl-2-acetylglycerophosphocholine Esterase Activity Positive Regulation Of Protein Metabolic Process Microtubule-based Process Positive Regulation Of Cell Maturation Platelet Activating Factor Metabolic Process Positive Regulation Of Acrosome Reaction Importin-alpha Family Protein Binding Golgi Ribbon Formation Golgi Cis Cisterna Membraneless Organelle Assembly Asymmetric Cell Division Cilium Disassembly Centrosome Separation Spindle Assembly Involved In Female Meiosis Calcium-dependent Phospholipase A2 Activity Phosphatidylcholine Catabolic Process
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