KRTAP6-3 and HHEX

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRTAP6-3	HHEX
Description		keratin associated protein 6-3	hematopoietically expressed homeobox
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament	Chromatin Nucleus Cytoplasm Nuclear Body Protein-DNA Complex
	Molecular Function	Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Eukaryotic Initiation Factor 4E Binding DNA Binding, Bending TBP-class Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Translation Regulator Activity DNA-binding Transcription Factor Binding
	Biological Process	Keratinization	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Regulation Of MRNA Export From Nucleus Negative Regulation Of Transcription By Competitive Promoter Binding Wnt Signaling Pathway Negative Regulation Of Angiogenesis Cell Differentiation Positive Regulation Of Wnt Signaling Pathway B Cell Differentiation Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Localization To Nucleus Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Leukocyte Proliferation DNA Conformation Change Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cytoplasmic Translational Initiation
Pathways			Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Drugs
Diseases			Type II diabetes mellitus
GWAS			Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Asthma ( 31619474) Birth weight ( 31043758 27680694) Body mass index ( 28892062) Circulating leptin levels or type 2 diabetes ( 32341051) Corrected insulin response ( 24699409) Corrected insulin response adjusted for insulin sensitivity index ( 24699409) Dehydroepiandrosterone sulphate levels ( 21533175) Eosinophil count ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Hemoglobin A1c levels ( 29403010) Inflammatory bowel disease ( 28067908) Insulin disposition index ( 24699409) Insulin levels in response to oral glucose tolerance test (30 minutes) ( 29093273) Intraocular pressure ( 29785010) Multiple sclerosis ( 24076602 21833088 31604244) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Type 2 diabetes ( 32499647 30054458 30297969 30718926 29358691 17293876 28869590 26818947 24509480 23945395 22885922 22693455 20862305 20581827 19401414 18372903 17463249 17463248 17463246)
Interacting Genes		160 interacting genes: ADAMTSL4 AGXT ARID5A ARMC7 ATOSB ATPAF2 AUTS2 BAG4 BEX2 BSCL2 C11orf87 CAMK2A CAMK2B CAMK2G CARHSP1 CCDC120 CCDC24 CCER1 CELF5 CHRD CLCNKA CNNM3 COL8A1 CREB5 CRY2 CTSZ CYSRT1 DALRD3 DHRS1 DMRT3 FADS6 FAM83A FBXW5 FCHO1 FOXD2 FOXD4L1 GATA2 GATA3 GLYCTK GNE GPS2 HAPLN2 HHEX HOXA1 HOXB5 HOXB9 HOXC8 HR HYAL2 ILF2 INCA1 INPP5D ITGB4 KANK2 KPRP KRT20 KRTAP11-1 KRTAP12-2 KRTAP19-2 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP26-1 KRTAP4-4 KRTAP6-1 KRTAP6-2 LAGE3 LCE1A LCE1B LCE1C LCE1E LCE1F LCE2A LCE2B LCE2C LCE3A LCE3C LCE3D LCE3E LCE5A LGALS9 LNX1 MAGED1 MAPK1IP1L MAPKBP1 MBD3L2 MED25 MEIS2 MEOX2 MGAT5B NODAL NOTO NR4A3 OLIG3 OTX1 OXER1 P4HB PATZ1 PCDHB14 PGAP6 PHETA1 PHLDA1 PIGS PITX1 PLSCR4 POU4F2 POU4F3 PPP1R37 PRMT8 PROP1 PRPF31 PRR13 PRR3 PRR35 PSMA1 PVR RAB3IL1 RAD54L2 RASD1 RHBDL1 RUNX1T1 SAMD7 SAXO4 SAXO5 SEMA4C SH3KBP1 SLC15A2 SLC22A5 SMARCC1 SMARCE1 SMCP SNRPB SNRPC SNX18 STK16 STRA6 TAOK2 TBX2 TBX6 TCAF1 TCF7L2 TEKT4 TENT2 TFAP2D TLE5 TLX3 TNIP1 TNS2 TSPYL6 TYK2 VASN VENTX VSTM4 WDR25 ZBTB32 ZIC1 ZNF414 ZNF497 ZNF575 ZNF79	41 interacting genes: ABI1 ABI2 APOBEC3C CYSRT1 EFEMP2 GATA2 GATA6 JUN KHDRBS2 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP19-1 KRTAP2-3 KRTAP2-4 KRTAP4-12 KRTAP5-7 KRTAP5-8 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 MDFI NBPF19 NOTCH2NLA PFDN5 PML PSMA3 PSTPIP1 RBMY1F RBMY1J SOX10 SOX8 TLE1 TLE5 TP53BP2 TRMT6
Entrez ID		337968	3087
HPRD ID		11220	06829
Ensembl ID		ENSG00000212938	ENSG00000152804
Uniprot IDs			Q03014
PDB IDs			2E1O
Enriched GO Terms of Interacting Partners?		Protein Binding Keratinization Epidermis Development Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Chromatin Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Tissue Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Intermediate Filament Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription DNA Binding Developmental Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Calcium- And Calmodulin-dependent Protein Kinase Complex Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Inner Ear Morphogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process System Development Transcription Regulator Complex Pattern Specification Process Cell Fate Specification Regulation Of Gene Expression Anatomical Structure Morphogenesis Embryonic Morphogenesis Regulation Of Primary Metabolic Process Embryonic Pattern Specification Myoblast Fate Commitment SnRNP Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway	Intermediate Filament Keratin Filament Identical Protein Binding Negative Regulation Of Wnt Signaling Pathway Cytosol Negative Regulation Of RNA Biosynthetic Process SH3 Domain Binding Actin-based Cell Projection Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of RNA Metabolic Process Transcription Regulator Complex Enteric Nervous System Development SCAR Complex Anatomical Structure Morphogenesis Keratinization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Filopodium Tip
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