IARS and GARS

Number of citations of the paper that reports this interaction (PMID 8816763)
17

Data Source:
HPRD (two hybrid)

		IARS	GARS
Gene Name		isoleucyl-tRNA synthetase	glycyl-tRNA synthetase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm Mitochondrial Matrix Cytosol Secretory Granule Extracellular Vesicular Exosome
	Molecular Function	Aminoacyl-tRNA Editing Activity Isoleucine-tRNA Ligase Activity Protein Binding ATP Binding	Glycine-tRNA Ligase Activity ATP Binding Protein Dimerization Activity
	Biological Process	Osteoblast Differentiation TRNA Aminoacylation For Protein Translation Isoleucyl-tRNA Aminoacylation Regulation Of Translational Fidelity Gene Expression	TRNA Aminoacylation For Protein Translation Glycyl-tRNA Aminoacylation Gene Expression Diadenosine Tetraphosphate Biosynthetic Process
Pathways		Cytosolic tRNA aminoacylation tRNA Aminoacylation	Cytosolic tRNA aminoacylation tRNA Aminoacylation Mitochondrial tRNA aminoacylation
Drugs		L-Isoleucine	Glycine
Diseases
GWAS
Protein-Protein Interactions		5 interactors: APP AR EPRS GARS SNCA	6 interactors: CD44 CELSR2 EEF1D IARS MAP3K10 MAPK8
Entrez ID		3376	2617
HPRD ID		02832	02617
Ensembl ID		ENSG00000196305	ENSG00000106105
Uniprot IDs		P41252 Q6P0M4 Q7L4K8	P41250
PDB IDs			2PME 2PMF 2Q5H 2Q5I 2ZT5 2ZT6 2ZT7 2ZT8 2ZXF
Enriched GO Terms of Interacting Partners?		Posttranscriptional Regulation Of Gene Expression TRNA Aminoacylation For Protein Translation Negative Regulation Of Thrombin Receptor Signaling Pathway Glycyl-tRNA Aminoacylation Negative Regulation Of Integrin Biosynthetic Process Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake TRNA Aminoacylation Adult Locomotory Behavior Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Peptidase Activity Cell Growth Prolyl-tRNA Aminoacylation Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Synaptic Growth At Neuromuscular Junction Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Adult Behavior Negative Regulation Of Protein Metabolic Process Response To Interferon-gamma Synapse Organization Glutamyl-tRNA Aminoacylation Positive Regulation Of Integrin Biosynthetic Process Negative Regulation Of Dopamine Metabolic Process Dopamine Uptake Involved In Synaptic Transmission Collateral Sprouting In Absence Of Injury Negative Regulation Of Serotonin Uptake Negative Regulation Of Cellular Respiration Intracellular Receptor Signaling Pathway Nitrogen Compound Metabolic Process Carboxylic Acid Metabolic Process Regulation Of Integrin Biosynthetic Process Negative Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Oxidative Phosphorylation Diadenosine Tetraphosphate Biosynthetic Process Locomotory Behavior Collateral Sprouting Axon Midline Choice Point Recognition Organic Acid Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Response To Iron(II) Ion Cellular Response To Copper Ion TRNA Metabolic Process Negative Regulation Of Endopeptidase Activity	Peptidyl-threonine Phosphorylation Regulation Of Gene Expression Positive Regulation Of Signal Transduction JNK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Peptidyl-serine Phosphorylation Isoleucyl-tRNA Aminoacylation Positive Regulation Of Monocyte Aggregation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Monocyte Aggregation Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Neural Plate Anterior/posterior Regionalization JUN Phosphorylation Apoptotic Process MAPK Cascade Programmed Cell Death Positive Regulation Of Deacetylase Activity Cell Death Death Wound Healing Involved In Inflammatory Response Positive Regulation Of Determination Of Dorsal Identity Cerebrospinal Fluid Secretion Wnt Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Signal Transduction By Phosphorylation Ossification Activation Of JNKK Activity Regulation Of Signal Transduction Positive Regulation Of Heterotypic Cell-cell Adhesion Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Cellular Response To Nitric Oxide Hyaluronan Catabolic Process Regulation Of Signaling Regulation Of Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Signaling Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Nitric Oxide Cell Communication Regulation Of Apoptotic Process Regulation Of Translational Fidelity Regulation Of Cell Death Positive Regulation Of MAPK Cascade Branching Involved In Prostate Gland Morphogenesis
Tagcloud ?		amputation ankle autogenous brachial cli conduit conduits demographics diabetics discouraged duplex expect fisher grafting inflow infrainguinal limb log nondiabetic nondiabetics outflow patency quantity rank salvage surgeon table technical	anxiety checklist depression extent former friendship greatly immigrants immigration income incomes job korean nonimmigrants nonprofessional occupation occupations perceived professional psychopathology responded revised satisfaction scales scored scores somatization spouses support
Tagcloud (Difference) ?		amputation ankle autogenous brachial cli conduit conduits demographics diabetics discouraged duplex expect fisher grafting inflow infrainguinal limb log nondiabetic nondiabetics outflow patency quantity rank salvage surgeon table technical	anxiety checklist depression extent former friendship greatly immigrants immigration income incomes job korean nonimmigrants nonprofessional occupation occupations perceived professional psychopathology responded revised satisfaction scales scored scores somatization spouses support
Tagcloud (Intersection) ?