GARS1 and MAP3K10

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GARS1	MAP3K10
Description		glycyl-tRNA synthetase 1	mitogen-activated protein kinase kinase kinase 10
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Secretory Granule Axon Cell Projection Extracellular Exosome	Cytoplasm
	Molecular Function	Nucleotide Binding Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) Activity Aminoacyl-tRNA Ligase Activity Glycine-tRNA Ligase Activity Protein Binding ATP Binding Transferase Activity Hydrolase Activity Ligase Activity Identical Protein Binding Protein Dimerization Activity ATP:ATP Adenylyltransferase Activity	Nucleotide Binding Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Homodimerization Activity BHLH Transcription Factor Binding Protein Serine Kinase Activity
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Glycyl-tRNA Aminoacylation Diadenosine Tetraphosphate Biosynthetic Process Mitochondrial Glycyl-tRNA Aminoacylation	Apoptotic Process Signal Transduction Smoothened Signaling Pathway JNK Cascade Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of JUN Kinase Activity Negative Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Protein Autophosphorylation
Pathways		Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation
Drugs		Glycine	Fostamatinib
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Distal hereditary motor neuropathies (dHMN)
GWAS			Birth weight ( 31043758) Resting heart rate ( 27798624)
Interacting Genes		12 interacting genes: CD44 CEBPA CELSR2 DUX4 EEF1D HSPB2 IARS1 LINC01554 MAP3K10 MAPK8 NAE1 NEDD8	31 interacting genes: ABL2 CDC42 CEACAM1 CLTC CNKSR1 COPS2 DLG4 DNM1 DNM1L GARS1 HGS HTT KIF17 KIF3A KIF3B KIFAP3 LCOR MAP2K4 MAPK1 MAPK14 MAPK8IP1 MAPK8IP2 MAPK9 NEUROD1 PHB1 RAC1 RACGAP1 SH3RF1 SMURF1 TUBB YWHAE
Entrez ID		2617	4294
HPRD ID		02617	02533
Ensembl ID		ENSG00000106105	ENSG00000130758
Uniprot IDs		P41250	Q02779
PDB IDs		2PME 2PMF 2Q5H 2Q5I 2ZT5 2ZT6 2ZT7 2ZT8 2ZXF 4KQE 4KR2 4KR3 4QEI 5E6M	2RF0
Enriched GO Terms of Interacting Partners?		Peptidyl-threonine Phosphorylation Protein Neddylation Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Peptidyl-serine Phosphorylation Regulation Of Postsynapse Assembly	MAPK Cascade Kinesin II Complex Protein Phosphatase Binding Cytoplasm Vesicle-mediated Transport Cytoskeleton-dependent Intracellular Transport Plus-end-directed Vesicle Transport Along Microtubule Regulation Of Signal Transduction Dendrite Cytoplasm Signal Transduction Intracellular Signaling Cassette Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Plus-end-directed Organelle Transport Along Microtubule Cytosol Organelle Transport Along Microtubule Regulation Of Multicellular Organismal Process Transport Along Microtubule Nucleotide Binding Anterograde Dendritic Transport Regulation Of Cell Communication Regulation Of Signaling Endocytosis Extracellular Exosome Protein Kinase Binding Intracellular Protein Localization Cellular Localization Vesicle Transport Along Microtubule Kinesin Complex MAP-kinase Scaffold Activity Membrane Invagination Receptor Localization To Synapse Regulation Of Transport Regulation Of Immune System Process Microtubule Microtubule-based Transport MAP Kinase Activity Positive Regulation Of Cellular Component Organization Vesicle Cytoskeletal Trafficking Postsynapse Dendritic Transport Negative Regulation Of Signal Transduction JNK Cascade Cell Surface Receptor Signaling Pathway Mitotic Spindle Intracellular Transport Regulation Of Vesicle-mediated Transport Plus-end-directed Microtubule Motor Activity Microtubule Binding Microtubule Cytoskeleton Positive Regulation Of Leukocyte Migration
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