GARS and MAP3K10

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GARS	MAP3K10
Gene Name		glycyl-tRNA synthetase	mitogen-activated protein kinase kinase kinase 10
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrial Matrix Cytosol Secretory Granule Extracellular Vesicular Exosome	Cytoplasm
	Molecular Function	Glycine-tRNA Ligase Activity ATP Binding Protein Dimerization Activity	Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity ATP Binding Protein Homodimerization Activity BHLH Transcription Factor Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Glycyl-tRNA Aminoacylation Gene Expression Diadenosine Tetraphosphate Biosynthetic Process	Apoptotic Process Signal Transduction Smoothened Signaling Pathway JNK Cascade Activation Of JNKK Activity Activation Of JUN Kinase Activity Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of JUN Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Protein Autophosphorylation
Pathways		Cytosolic tRNA aminoacylation tRNA Aminoacylation Mitochondrial tRNA aminoacylation
Drugs		Glycine
Diseases
GWAS
Protein-Protein Interactions		6 interactors: CD44 CELSR2 EEF1D IARS MAP3K10 MAPK8	30 interactors: ABL2 CDC42 CEACAM1 CLTC CNKSR1 COPS2 DLG4 DNM1 DNM1L GARS HGS HTT KIAA1804 KIF17 KIF3A KIF3B KIFAP3 MAP2K4 MAPK1 MAPK14 MAPK8IP1 MAPK8IP2 MAPK9 NEUROD1 PHB RAC1 RACGAP1 SH3RF1 TUBB YWHAE
Entrez ID		2617	4294
HPRD ID		02617	02533
Ensembl ID		ENSG00000106105	ENSG00000130758
Uniprot IDs		P41250	Q02779
PDB IDs		2PME 2PMF 2Q5H 2Q5I 2ZT5 2ZT6 2ZT7 2ZT8 2ZXF	2RF0
Enriched GO Terms of Interacting Partners?		Peptidyl-threonine Phosphorylation Regulation Of Gene Expression Positive Regulation Of Signal Transduction JNK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Peptidyl-serine Phosphorylation Isoleucyl-tRNA Aminoacylation Positive Regulation Of Monocyte Aggregation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Monocyte Aggregation Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Neural Plate Anterior/posterior Regionalization JUN Phosphorylation Apoptotic Process MAPK Cascade Programmed Cell Death Positive Regulation Of Deacetylase Activity Cell Death Death Wound Healing Involved In Inflammatory Response Positive Regulation Of Determination Of Dorsal Identity Cerebrospinal Fluid Secretion Wnt Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Signal Transduction By Phosphorylation Ossification Activation Of JNKK Activity Regulation Of Signal Transduction Positive Regulation Of Heterotypic Cell-cell Adhesion Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Cellular Response To Nitric Oxide Hyaluronan Catabolic Process Regulation Of Signaling Regulation Of Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Signaling Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Nitric Oxide Cell Communication Regulation Of Apoptotic Process Regulation Of Translational Fidelity Regulation Of Cell Death Positive Regulation Of MAPK Cascade Branching Involved In Prostate Gland Morphogenesis	Regulation Of Intracellular Signal Transduction Movement Of Cell Or Subcellular Component Signal Transduction Regulation Of Signal Transduction Regulation Of Stress-activated MAPK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Signaling Regulation Of Signaling Cell Communication Neurogenesis Cell Differentiation Regulation Of JNK Cascade Generation Of Neurons Positive Regulation Of Signal Transduction Blood Coagulation Hemostasis Regulation Of MAPK Cascade Organelle Organization Cellular Localization Cellular Response To Stimulus Neuron Differentiation Response To Stimulus Regulation Of Apoptotic Process Developmental Process Organelle Transport Along Microtubule Regulation Of Phosphorus Metabolic Process MAPK Cascade Response To Stress Intracellular Transport Regulation Of Cell Death Protein Localization Nervous System Development Cytoskeleton-dependent Intracellular Transport Regulation Of Body Fluid Levels Positive Regulation Of Intracellular Signal Transduction Plus-end-directed Vesicle Transport Along Microtubule Wound Healing Regulation Of Catalytic Activity Signal Transduction By Phosphorylation Membrane Organization Transport JNK Cascade Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Microtubule-based Movement Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Vesicle Transport Along Microtubule Response To Wounding
Tagcloud ?		anxiety checklist depression extent former friendship greatly immigrants immigration income incomes job korean nonimmigrants nonprofessional occupation occupations perceived professional psychopathology responded revised satisfaction scales scored scores somatization spouses support	artp calculating chief convergence dusp2 hrgg il2ra il6 il8ra il8rb infgr1 irf2 merits mmp1 nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2
Tagcloud (Difference) ?		anxiety checklist depression extent former friendship greatly immigrants immigration income incomes job korean nonimmigrants nonprofessional occupation occupations perceived professional psychopathology responded revised satisfaction scales scored scores somatization spouses support	artp calculating chief convergence dusp2 hrgg il2ra il6 il8ra il8rb infgr1 irf2 merits mmp1 nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2
Tagcloud (Intersection) ?