GARS1 and NAE1

Number of citations of the paper that reports this interaction (PubMedID 27348078)
58

Data Source:
BioGRID (pull down, affinity chromatography technology)

		GARS1	NAE1
Description		glycyl-tRNA synthetase 1	NEDD8 activating enzyme E1 subunit 1
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Secretory Granule Axon Cell Projection Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Membrane Protein-containing Complex Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) Activity Aminoacyl-tRNA Ligase Activity Glycine-tRNA Ligase Activity Protein Binding ATP Binding Transferase Activity Hydrolase Activity Ligase Activity Identical Protein Binding Protein Dimerization Activity ATP:ATP Adenylyltransferase Activity	Protein Binding Ubiquitin-like Modifier Activating Enzyme Activity NEDD8 Activating Enzyme Activity Ubiquitin Protein Ligase Binding Protein Heterodimerization Activity
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Glycyl-tRNA Aminoacylation Diadenosine Tetraphosphate Biosynthetic Process Mitochondrial Glycyl-tRNA Aminoacylation	Apoptotic Process Signal Transduction Mitotic DNA Replication Checkpoint Signaling Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Protein Neddylation Neuron Apoptotic Process Regulation Of Postsynapse Assembly
Pathways		Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation	Neddylation
Drugs		Glycine	ATP
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Distal hereditary motor neuropathies (dHMN)
GWAS			Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)
Interacting Genes		12 interacting genes: CD44 CEBPA CELSR2 DUX4 EEF1D HSPB2 IARS1 LINC01554 MAP3K10 MAPK8 NAE1 NEDD8	12 interacting genes: ALG8 APP CEBPA GARS1 NEDD8 OGT SREBF2 TP53BP2 TRIP12 UBA3 UBE2F UBQLN4
Entrez ID		2617	8883
HPRD ID		02617	04545
Ensembl ID		ENSG00000106105	ENSG00000159593
Uniprot IDs		P41250	Q13564
PDB IDs		2PME 2PMF 2Q5H 2Q5I 2ZT5 2ZT6 2ZT7 2ZT8 2ZXF 4KQE 4KR2 4KR3 4QEI 5E6M	1R4M 1R4N 1TT5 1YOV 2NVU 3DBH 3DBL 3DBR 3GZN
Enriched GO Terms of Interacting Partners?		Peptidyl-threonine Phosphorylation Protein Neddylation Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Peptidyl-serine Phosphorylation Regulation Of Postsynapse Assembly	Protein Neddylation Regulation Of Proteolysis NEDD8 Transferase Activity Protein Metabolic Process Regulation Of Amyloid-beta Clearance Regulation Of Protein Catabolic Process Protein-containing Complex Macromolecule Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteolysis Regulation Of Synapse Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Cytosol Identical Protein Binding Regulation Of Proteasomal Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Glycyl-tRNA Aminoacylation Mitochondrial Glycyl-tRNA Aminoacylation Glycine-tRNA Ligase Activity ATP:ATP Adenylyltransferase Activity Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Dolichyl-phosphate-glucose-glycolipid Alpha-glucosyltransferase Activity Dolichyl Pyrophosphate Glc1Man9GlcNAc2 Alpha-1,3-glucosyltransferase Activity Regulation Of Cell Junction Assembly Regulation Of Carbohydrate Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Acetylcholine Receptor Activator Activity Regulation Of ATP Metabolic Process Regulation Of Synapse Organization Regulation Of MiRNA Transcription Regulation Of Small Molecule Metabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Response To Vitamin B2 C/EBP Complex Diadenosine Tetraphosphate Biosynthetic Process C-8 Sterol Isomerase Activity NEDD8 Activating Enzyme Activity
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