IARS and EPRS

Number of citations of the paper that reports this interaction (PMID 9556618)
13

Data Source:
HPRD (two hybrid, in vitro)

		IARS	EPRS
Gene Name		isoleucyl-tRNA synthetase	glutamyl-prolyl-tRNA synthetase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane Extracellular Vesicular Exosome	Cytoplasm Cytosol Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex Ribonucleoprotein Complex GAIT Complex
	Molecular Function	Aminoacyl-tRNA Editing Activity Isoleucine-tRNA Ligase Activity Protein Binding ATP Binding	Glutamate-tRNA Ligase Activity Proline-tRNA Ligase Activity Protein Binding ATP Binding RNA Stem-loop Binding
	Biological Process	Osteoblast Differentiation TRNA Aminoacylation For Protein Translation Isoleucyl-tRNA Aminoacylation Regulation Of Translational Fidelity Gene Expression	TRNA Aminoacylation For Protein Translation Glutamyl-tRNA Aminoacylation Prolyl-tRNA Aminoacylation Protein Complex Assembly Gene Expression Negative Regulation Of Translation Cellular Response To Interferon-gamma
Pathways		Cytosolic tRNA aminoacylation tRNA Aminoacylation	Cytosolic tRNA aminoacylation tRNA Aminoacylation
Drugs		L-Isoleucine	L-Glutamic Acid L-Proline \'5\'-O-(N-(L-Prolyl)-Sulfamoyl)Adenosine 5\'-O-(N-(L-Cysteinyl)-Sulfamoyl)Adenosine \'5\'-O-(N-(L-Alanyl)-Sulfamoyl)Adenosine
Diseases
GWAS
Protein-Protein Interactions		5 interactors: APP AR EPRS GARS SNCA	12 interactors: AIMP2 ARL4D DUS2 EEF1D HSP90AA1 IARS NEDD4 NELFCD POU2F1 RARS SYNCRIP TAB1
Entrez ID		3376	2058
HPRD ID		02832	00703
Ensembl ID		ENSG00000196305	ENSG00000136628
Uniprot IDs		P41252 Q6P0M4 Q7L4K8	P07814
PDB IDs			1FYJ 4HVC
Enriched GO Terms of Interacting Partners?		Posttranscriptional Regulation Of Gene Expression TRNA Aminoacylation For Protein Translation Negative Regulation Of Thrombin Receptor Signaling Pathway Glycyl-tRNA Aminoacylation Negative Regulation Of Integrin Biosynthetic Process Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake TRNA Aminoacylation Adult Locomotory Behavior Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Peptidase Activity Cell Growth Prolyl-tRNA Aminoacylation Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Synaptic Growth At Neuromuscular Junction Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Adult Behavior Negative Regulation Of Protein Metabolic Process Response To Interferon-gamma Synapse Organization Glutamyl-tRNA Aminoacylation Positive Regulation Of Integrin Biosynthetic Process Negative Regulation Of Dopamine Metabolic Process Dopamine Uptake Involved In Synaptic Transmission Collateral Sprouting In Absence Of Injury Negative Regulation Of Serotonin Uptake Negative Regulation Of Cellular Respiration Intracellular Receptor Signaling Pathway Nitrogen Compound Metabolic Process Carboxylic Acid Metabolic Process Regulation Of Integrin Biosynthetic Process Negative Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Oxidative Phosphorylation Diadenosine Tetraphosphate Biosynthetic Process Locomotory Behavior Collateral Sprouting Axon Midline Choice Point Recognition Organic Acid Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Response To Iron(II) Ion Cellular Response To Copper Ion TRNA Metabolic Process Negative Regulation Of Endopeptidase Activity	TRNA Metabolic Process TRNA Aminoacylation For Protein Translation TRNA Aminoacylation RNA Metabolic Process NcRNA Metabolic Process Nitrogen Compound Metabolic Process Translation Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Respiratory System Development Nucleobase-containing Compound Metabolic Process Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Isoleucyl-tRNA Aminoacylation Cellular Amino Acid Metabolic Process Metabolic Process Regulation Of Cellular Protein Metabolic Process Protein Import Into Mitochondrial Outer Membrane Osteoblast Differentiation Viral Process Negative Regulation Of Cellular Metabolic Process CRD-mediated MRNA Stabilization Arginyl-tRNA Aminoacylation Progesterone Receptor Signaling Pathway Olfactory Placode Formation Immune Response Negative Regulation Of Gene Expression Regulation Of Cellular Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Type II Pneumocyte Differentiation Negative Regulation Of Biosynthetic Process Cell Differentiation Positive Regulation Of Metabolic Process Glucocorticoid Receptor Signaling Pathway Activation Of MAPKKK Activity Intracellular Receptor Signaling Pathway Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Lens Induction In Camera-type Eye Macromolecule Biosynthetic Process Heart Morphogenesis Positive Regulation Of Cellular Metabolic Process Protein Targeting To Lysosome Negative Regulation Of Sodium Ion Transport
Tagcloud ?		amputation ankle autogenous brachial cli conduit conduits demographics diabetics discouraged duplex expect fisher grafting inflow infrainguinal limb log nondiabetic nondiabetics outflow patency quantity rank salvage surgeon table technical	adequate analgesic analgesics assessments caution codeine comparative documentation dying electronic feasible healthcare hospitalised instrument intensity interpretation limitation morphine norwegian old oldest pain palliative paracetamol regard resident retrospective workers young
Tagcloud (Difference) ?		amputation ankle autogenous brachial cli conduit conduits demographics diabetics discouraged duplex expect fisher grafting inflow infrainguinal limb log nondiabetic nondiabetics outflow patency quantity rank salvage surgeon table technical	adequate analgesic analgesics assessments caution codeine comparative documentation dying electronic feasible healthcare hospitalised instrument intensity interpretation limitation morphine norwegian old oldest pain palliative paracetamol regard resident retrospective workers young
Tagcloud (Intersection) ?