IARS

Gene Name		isoleucyl-tRNA synthetase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane Extracellular Vesicular Exosome
	Molecular Function	Aminoacyl-tRNA Editing Activity Isoleucine-tRNA Ligase Activity Protein Binding ATP Binding
	Biological Process	Osteoblast Differentiation TRNA Aminoacylation For Protein Translation Isoleucyl-tRNA Aminoacylation Regulation Of Translational Fidelity Gene Expression
Pathways		Cytosolic tRNA aminoacylation tRNA Aminoacylation
Drugs		L-Isoleucine
Diseases
GWAS
Protein-protein Interactions		5 interactors: APP AR EPRS GARS SNCA
Entrez ID		3376
HPRD ID		02832
Ensembl ID		ENSG00000196305
Uniprot IDs		P41252 Q6P0M4 Q7L4K8
PDB IDs
Enriched GO Terms of Interacting Partners?		Posttranscriptional Regulation Of Gene Expression TRNA Aminoacylation For Protein Translation Negative Regulation Of Thrombin Receptor Signaling Pathway Glycyl-tRNA Aminoacylation Negative Regulation Of Integrin Biosynthetic Process Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake TRNA Aminoacylation Adult Locomotory Behavior Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Peptidase Activity Cell Growth Prolyl-tRNA Aminoacylation Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Synaptic Growth At Neuromuscular Junction Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Adult Behavior Negative Regulation Of Protein Metabolic Process Response To Interferon-gamma Synapse Organization Glutamyl-tRNA Aminoacylation Positive Regulation Of Integrin Biosynthetic Process Negative Regulation Of Dopamine Metabolic Process Dopamine Uptake Involved In Synaptic Transmission Collateral Sprouting In Absence Of Injury Negative Regulation Of Serotonin Uptake Negative Regulation Of Cellular Respiration Intracellular Receptor Signaling Pathway Nitrogen Compound Metabolic Process Carboxylic Acid Metabolic Process Regulation Of Integrin Biosynthetic Process Negative Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Oxidative Phosphorylation Diadenosine Tetraphosphate Biosynthetic Process Locomotory Behavior Collateral Sprouting Axon Midline Choice Point Recognition Organic Acid Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Response To Iron(II) Ion Cellular Response To Copper Ion TRNA Metabolic Process Negative Regulation Of Endopeptidase Activity
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