GARS and EEF1D

Number of citations of the paper that reports this interaction (PMID 11829477)
11

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		GARS	EEF1D
Gene Name		glycyl-tRNA synthetase	eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrial Matrix Cytosol Secretory Granule Extracellular Vesicular Exosome	Nucleus Nucleolus Cytoplasm Cytosol Eukaryotic Translation Elongation Factor 1 Complex
	Molecular Function	Glycine-tRNA Ligase Activity ATP Binding Protein Dimerization Activity	DNA Binding Translation Elongation Factor Activity Signal Transducer Activity Protein Binding Translation Factor Activity, Nucleic Acid Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Glycyl-tRNA Aminoacylation Gene Expression Diadenosine Tetraphosphate Biosynthetic Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Translation Translational Elongation Signal Transduction Gene Expression Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Protein Metabolic Process
Pathways		Cytosolic tRNA aminoacylation tRNA Aminoacylation Mitochondrial tRNA aminoacylation	Translation Eukaryotic Translation Elongation
Drugs		Glycine
Diseases
GWAS
Protein-Protein Interactions		6 interactors: CD44 CELSR2 EEF1D IARS MAP3K10 MAPK8	33 interactors: ARHGAP21 ASCC2 ATG7 CAMSAP2 CD48 CDK1 CRMP1 CSNK2A1 CTBP1 CTBP2 ECH1 EEF1G EPRS ERP27 FOS FRA10AC1 GARS HEXDC KARS KTN1 MAP1B NR2F1 POT1 PRKCA RELA RPS6KA1 SIAH1 SIAH2 SQSTM1 TERF1 TINF2 TPT1 VARS
Entrez ID		2617	1936
HPRD ID		02617	00560
Ensembl ID		ENSG00000106105	ENSG00000104529
Uniprot IDs		P41250	B2RAR6 D3DWK1 P29692
PDB IDs		2PME 2PMF 2Q5H 2Q5I 2ZT5 2ZT6 2ZT7 2ZT8 2ZXF
Enriched GO Terms of Interacting Partners?		Peptidyl-threonine Phosphorylation Regulation Of Gene Expression Positive Regulation Of Signal Transduction JNK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Peptidyl-serine Phosphorylation Isoleucyl-tRNA Aminoacylation Positive Regulation Of Monocyte Aggregation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Monocyte Aggregation Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Neural Plate Anterior/posterior Regionalization JUN Phosphorylation Apoptotic Process MAPK Cascade Programmed Cell Death Positive Regulation Of Deacetylase Activity Cell Death Death Wound Healing Involved In Inflammatory Response Positive Regulation Of Determination Of Dorsal Identity Cerebrospinal Fluid Secretion Wnt Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Signal Transduction By Phosphorylation Ossification Activation Of JNKK Activity Regulation Of Signal Transduction Positive Regulation Of Heterotypic Cell-cell Adhesion Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Cellular Response To Nitric Oxide Hyaluronan Catabolic Process Regulation Of Signaling Regulation Of Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Signaling Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Nitric Oxide Cell Communication Regulation Of Apoptotic Process Regulation Of Translational Fidelity Regulation Of Cell Death Positive Regulation Of MAPK Cascade Branching Involved In Prostate Gland Morphogenesis	Negative Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Response To External Stimulus Negative Regulation Of Telomere Maintenance Regulation Of Chromosome Organization Axonogenesis Regulation Of Telomere Maintenance Via Telomerase Axon Development Negative Regulation Of Cellular Protein Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Toll-like Receptor 5 Signaling Pathway Negative Regulation Of Cellular Metabolic Process Toll-like Receptor 10 Signaling Pathway Cell Differentiation Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Apoptotic Process Neuron Projection Morphogenesis Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death MyD88-independent Toll-like Receptor Signaling Pathway Diadenosine Tetraphosphate Biosynthetic Process Regulation Of Telomere Maintenance Toll-like Receptor 3 Signaling Pathway Regulation Of Cell Death Cellular Macromolecule Biosynthetic Process MyD88-dependent Toll-like Receptor Signaling Pathway Viral Genome Replication Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cell Death Macromolecule Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Schwann Cell Differentiation Neuron Projection Development Neurotrophin TRK Receptor Signaling Pathway Cell Projection Morphogenesis Nucleobase-containing Compound Metabolic Process Axon Guidance Chemotaxis Neurotrophin Signaling Pathway Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Histone H4 Acetylation
Tagcloud ?		anxiety checklist depression extent former friendship greatly immigrants immigration income incomes job korean nonimmigrants nonprofessional occupation occupations perceived professional psychopathology responded revised satisfaction scales scored scores somatization spouses support
Tagcloud (Difference) ?		anxiety checklist depression extent former friendship greatly immigrants immigration income incomes job korean nonimmigrants nonprofessional occupation occupations perceived professional psychopathology responded revised satisfaction scales scored scores somatization spouses support
Tagcloud (Intersection) ?