GARS1 and CELSR2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		GARS1	CELSR2
Description		glycyl-tRNA synthetase 1	cadherin EGF LAG seven-pass G-type receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Secretory Granule Axon Cell Projection Extracellular Exosome	Cytoplasm Plasma Membrane Adherens Junction Membrane
	Molecular Function	Nucleotide Binding Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) Activity Aminoacyl-tRNA Ligase Activity Glycine-tRNA Ligase Activity Protein Binding ATP Binding Transferase Activity Hydrolase Activity Ligase Activity Identical Protein Binding Protein Dimerization Activity ATP:ATP Adenylyltransferase Activity	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Calcium Ion Binding
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Glycyl-tRNA Aminoacylation Diadenosine Tetraphosphate Biosynthetic Process Mitochondrial Glycyl-tRNA Aminoacylation	Cilium Movement Regulation Of DNA-templated Transcription Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Nervous System Development Axonogenesis Anterior/posterior Pattern Specification Wnt Signaling Pathway Ventricular System Development Neural Plate Anterior/posterior Regionalization Regulation Of Cell-cell Adhesion Regulation Of Protein Localization Cerebrospinal Fluid Secretion Cell-cell Adhesion Mediated By Cadherin Animal Organ Development Dendrite Morphogenesis Wnt Signaling Pathway, Planar Cell Polarity Pathway Cilium Assembly Motor Neuron Migration Plasma Membrane Bounded Cell Projection Organization
Pathways		Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation
Drugs		Glycine
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Distal hereditary motor neuropathies (dHMN)
GWAS			Abdominal aortic aneurysm ( 27899403) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cardiovascular disease risk factors ( 21943158) Cholesterol, total ( 19060911 20686565 28270201 26780889 25961943 24886709) Coronary artery disease ( 29212778 33020668) Coronary heart disease ( 21378988) HDL cholesterol ( 30275531 25961943) HDL cholesterol levels ( 30698716 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heart failure ( 31919418) Heel bone mineral density ( 30598549) LDL cholesterol ( 30275531 18193043 26780889 20686565 20864672 19060911 19060910 21347282 19060906 18262040 18193044 25961943 18179892) LDL cholesterol levels ( 32203549 30698716 31087446) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels in HIV infection ( 33109212) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipid metabolism phenotypes ( 19936222) Lipoprotein (a) levels ( 33730874) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Lipoprotein-associated phospholipase A2 activity and mass ( 22003152) Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease ( 28753643) Low density lipoprotein cholesterol levels ( 30911093 33339817 29403010 32902719 32154731 30718733) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antithrombotic agents) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 21909109) Myocardial infarction ( 33532862) Myocardial infarction (early onset) ( 19198609) Non-HDL cholesterol levels ( 32902719) Parental lifespan ( 30642433) Peripheral artery disease ( 31285632) Progranulin levels ( 21087763 29186428) Response to statin therapy ( 20339536) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 30275531 32902719 29403010 30911093 33339817 30718733)
Interacting Genes		12 interacting genes: CD44 CEBPA CELSR2 DUX4 EEF1D HSPB2 IARS1 LINC01554 MAP3K10 MAPK8 NAE1 NEDD8	3 interacting genes: GARS1 KLF6 PHF10
Entrez ID		2617	1952
HPRD ID		02617	05040
Ensembl ID		ENSG00000106105	ENSG00000143126
Uniprot IDs		P41250	Q9HCU4
PDB IDs		2PME 2PMF 2Q5H 2Q5I 2ZT5 2ZT6 2ZT7 2ZT8 2ZXF 4KQE 4KR2 4KR3 4QEI 5E6M
Enriched GO Terms of Interacting Partners?		Peptidyl-threonine Phosphorylation Protein Neddylation Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Peptidyl-serine Phosphorylation Regulation Of Postsynapse Assembly	Glycyl-tRNA Aminoacylation Mitochondrial Glycyl-tRNA Aminoacylation Glycine-tRNA Ligase Activity ATP:ATP Adenylyltransferase Activity Diadenosine Tetraphosphate Biosynthetic Process DN4 Thymocyte Differentiation Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) Activity Chromatin Lymphocyte Differentiation Positive Regulation Of Artery Morphogenesis Mononuclear Cell Differentiation TRNA Aminoacylation For Mitochondrial Protein Translation Regulation Of Artery Morphogenesis Leukocyte Differentiation Positive Thymic T Cell Selection Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive T Cell Selection RSC-type Complex NpBAF Complex Lymphocyte Activation Thymic T Cell Selection Negative Regulation Of Smooth Muscle Cell Differentiation Calcineurin-NFAT Signaling Cascade Leukocyte Activation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of MiRNA Transcription T Cell Selection Calcineurin-mediated Signaling Regulation Of Nucleotide-excision Repair SWI/SNF Complex Histone Acetyltransferase Activity
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