GARS and CELSR2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		GARS	CELSR2
Gene Name		glycyl-tRNA synthetase	cadherin, EGF LAG seven-pass G-type receptor 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrial Matrix Cytosol Secretory Granule Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Glycine-tRNA Ligase Activity ATP Binding Protein Dimerization Activity	G-protein Coupled Receptor Activity Calcium Ion Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Glycyl-tRNA Aminoacylation Gene Expression Diadenosine Tetraphosphate Biosynthetic Process	Neuron Migration Cilium Movement Regulation Of Transcription, DNA-templated Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules G-protein Coupled Receptor Signaling Pathway Wnt Signaling Pathway Ventricular System Development Neural Plate Anterior/posterior Regionalization Regulation Of Cell-cell Adhesion Regulation Of Protein Localization Cerebrospinal Fluid Secretion Cilium Assembly Dendrite Morphogenesis
Pathways		Cytosolic tRNA aminoacylation tRNA Aminoacylation Mitochondrial tRNA aminoacylation
Drugs		Glycine
Diseases
GWAS			Cardiovascular disease risk factors ( 21943158) Cholesterol, total ( 19060911 20686565) Coronary heart disease ( 21378988 21347282) LDL cholesterol ( 18262040 18179892 18193043 18193044 20864672 19060906 19060910 19060911 20686565) Lipid metabolism phenotypes ( 19936222) Lipoprotein-associated phospholipase A2 activity and mass ( 22003152) Metabolite levels ( 21909109) Myocardial infarction (early onset) ( 19198609) Progranulin levels ( 21087763) Response to statin therapy ( 20339536)
Protein-Protein Interactions		6 interactors: CD44 CELSR2 EEF1D IARS MAP3K10 MAPK8	3 interactors: GARS KLF6 PHF10
Entrez ID		2617	1952
HPRD ID		02617	05040
Ensembl ID		ENSG00000106105	ENSG00000143126
Uniprot IDs		P41250	Q9HCU4
PDB IDs		2PME 2PMF 2Q5H 2Q5I 2ZT5 2ZT6 2ZT7 2ZT8 2ZXF
Enriched GO Terms of Interacting Partners?		Peptidyl-threonine Phosphorylation Regulation Of Gene Expression Positive Regulation Of Signal Transduction JNK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Peptidyl-serine Phosphorylation Isoleucyl-tRNA Aminoacylation Positive Regulation Of Monocyte Aggregation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Monocyte Aggregation Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Neural Plate Anterior/posterior Regionalization JUN Phosphorylation Apoptotic Process MAPK Cascade Programmed Cell Death Positive Regulation Of Deacetylase Activity Cell Death Death Wound Healing Involved In Inflammatory Response Positive Regulation Of Determination Of Dorsal Identity Cerebrospinal Fluid Secretion Wnt Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Signal Transduction By Phosphorylation Ossification Activation Of JNKK Activity Regulation Of Signal Transduction Positive Regulation Of Heterotypic Cell-cell Adhesion Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Cellular Response To Nitric Oxide Hyaluronan Catabolic Process Regulation Of Signaling Regulation Of Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Signaling Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Nitric Oxide Cell Communication Regulation Of Apoptotic Process Regulation Of Translational Fidelity Regulation Of Cell Death Positive Regulation Of MAPK Cascade Branching Involved In Prostate Gland Morphogenesis	Glycyl-tRNA Aminoacylation Diadenosine Tetraphosphate Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process
Tagcloud ?		anxiety checklist depression extent former friendship greatly immigrants immigration income incomes job korean nonimmigrants nonprofessional occupation occupations perceived professional psychopathology responded revised satisfaction scales scored scores somatization spouses support	adds arealization axon axons barrel conditional contexts forebrain fzd3 guidance guidepost inactivation mimics navigation pcp perturbs planar polarity projections redundantly thalamic thalamocortical thalamus unexpectedly vangl vangl1 vangl2 wiring
Tagcloud (Difference) ?		anxiety checklist depression extent former friendship greatly immigrants immigration income incomes job korean nonimmigrants nonprofessional occupation occupations perceived professional psychopathology responded revised satisfaction scales scored scores somatization spouses support	adds arealization axon axons barrel conditional contexts forebrain fzd3 guidance guidepost inactivation mimics navigation pcp perturbs planar polarity projections redundantly thalamic thalamocortical thalamus unexpectedly vangl vangl1 vangl2 wiring
Tagcloud (Intersection) ?