HTR1A and S1PR3

Number of citations of the paper that reports this interaction (PMID 11854302)
10

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		HTR1A	S1PR3
Gene Name		5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	sphingosine-1-phosphate receptor 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Serotonin Receptor Activity Protein Binding	G-protein Coupled Receptor Activity Integrin Binding Lipid Binding Sphingosine-1-phosphate Receptor Activity
	Biological Process	Behavioral Fear Response G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Cell Proliferation Positive Regulation Of Cell Proliferation Regulation Of Serotonin Secretion Exploration Behavior Regulation Of Dopamine Metabolic Process Vasoconstriction Serotonin Metabolic Process Regulation Of Hormone Secretion Regulation Of Behavior	Cytokine Production Sphingosine-1-phosphate Signaling Pathway Inflammatory Response G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Proliferation Anatomical Structure Morphogenesis Regulation Of Interleukin-1 Beta Production Negative Regulation Of Establishment Of Endothelial Barrier
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Serotonin receptors	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Lysosphingolipid and LPA receptors
Drugs		Eletriptan Ziprasidone Methysergide Cabergoline Ropinirole Zolmitriptan Amitriptyline Olanzapine Clozapine Pramipexole Chlorpromazine Buspirone Nortriptyline Propranolol Lisuride Trazodone Sumatriptan Apomorphine Trimipramine Risperidone Alprenolol Ondansetron Naratriptan Pindolol Ergoloid mesylate Doxepin Nefazodone Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Penbutolol Yohimbine Acepromazine Alverine Molindone Pipotiazine Thioproperazine Iloperidone Rotigotine Asenapine Vilazodone Bopindolol Cinitapride Lurasidone
Diseases
GWAS		Alcohol and nictotine co-dependence ( 23216389) Body mass index ( 20935630)	Response to statin therapy (LDL-C) ( 22331829)
Protein-Protein Interactions		7 interactors: GABBR2 GNAI3 GPR26 HTR1B HTR1D S1PR1 S1PR3	4 interactors: GNA13 GNAI1 GNAQ HTR1A
Entrez ID		3350	1903
HPRD ID		00190	03572
Ensembl ID			ENSG00000213694
Uniprot IDs		A8K5W4 P08908 Q5ZGX3	Q99500
PDB IDs
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Negative Regulation Of Nucleotide Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Sphingosine-1-phosphate Signaling Pathway Serotonin Receptor Signaling Pathway Synaptic Transmission Negative Regulation Of Adenylate Cyclase Activity Regulation Of Behavior Negative Regulation Of Lyase Activity Signal Transduction Vasoconstriction Signaling Cell Communication Cell-cell Signaling Regulation Of Adenylate Cyclase Activity Cellular Response To Stimulus Regulation Of Cyclase Activity Regulation Of Blood Vessel Size Regulation Of Tube Size Cardiac Muscle Tissue Growth Involved In Heart Morphogenesis Negative Regulation Of Establishment Of Endothelial Barrier Cellular Response To Temperature Stimulus Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Response To Stimulus Growth Involved In Heart Morphogenesis Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Serotonin Secretion Intestine Smooth Muscle Contraction Cytosolic Calcium Ion Homeostasis Negative Regulation Of Endothelial Cell Differentiation Regulation Of Serotonin Secretion Drinking Behavior Negative Regulation Of Synaptic Transmission, GABAergic Cellular Calcium Ion Homeostasis Negative Regulation Of Stress Fiber Assembly Calcium Ion Homeostasis Blood Circulation G-protein Coupled Receptor Internalization Negative Regulation Of Actin Filament Bundle Assembly Blood Vessel Maturation Negative Regulation Of Synaptic Transmission, Glutamatergic Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation G-protein Coupled Receptor Signaling Pathway Blood Coagulation Hemostasis Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Positive Regulation Of Phospholipase Activity Wound Healing Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Cell Activation Response To Wounding Cell Surface Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Response To Stress Regulation Of Serotonin Secretion Phospholipase C-activating Dopamine Receptor Signaling Pathway Neuron Remodeling Regulation Of Melanocyte Differentiation Serotonin Metabolic Process Serotonin Receptor Signaling Pathway Signal Transduction Activation Of Phospholipase D Activity Maternal Behavior Regulation Of Dopamine Metabolic Process Signaling Cell Communication Behavior Regulation Of Catenin Import Into Nucleus Regulation Of Developmental Pigmentation Exploration Behavior Neuron Maturation Vasoconstriction Dopamine Receptor Signaling Pathway Behavioral Fear Response Cellular Response To Stimulus Forebrain Neuron Development Fear Response Cardiovascular System Development Patterning Of Blood Vessels Activation Of Phospholipase C Activity Vesicle Fusion Positive Regulation Of Phospholipase C Activity Rho Protein Signal Transduction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Forebrain Neuron Differentiation Glutamate Receptor Signaling Pathway
Tagcloud ?		analysing asynchronous chrna5 chrna7 circuit clamp develops earliest ergic grik1 grin2a htr1b innervation kcc2 lmc locomotor medial muscarinic neuromuscular neurotransmitter nicotinic ordered organised patch patterned recordings subtly synchronous transmitter	acetyl albumin alleviates ao bsa circulation equivalent excretion fty720 glucosaminidase gradually immunomodulatory infiltration ip killed mcp monocytes nephrectomy nephropathy overload reached s1pr1 saline sphingosine sphk1 synthesizing tubulointerstitium wistar
Tagcloud (Difference) ?		analysing asynchronous chrna5 chrna7 circuit clamp develops earliest ergic grik1 grin2a htr1b innervation kcc2 lmc locomotor medial muscarinic neuromuscular neurotransmitter nicotinic ordered organised patch patterned recordings subtly synchronous transmitter	acetyl albumin alleviates ao bsa circulation equivalent excretion fty720 glucosaminidase gradually immunomodulatory infiltration ip killed mcp monocytes nephrectomy nephropathy overload reached s1pr1 saline sphingosine sphk1 synthesizing tubulointerstitium wistar
Tagcloud (Intersection) ?