HTR1A and HTR1D

Number of citations of the paper that reports this interaction (PubMedID 11854302)
0

Data Source:
HPRD (in vitro, in vivo)

		HTR1A	HTR1D
Description		5-hydroxytryptamine receptor 1A	5-hydroxytryptamine receptor 1D
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Cell Projection Synapse	Plasma Membrane Membrane Dendrite Synapse
	Molecular Function	Gi/o-coupled Serotonin Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding Receptor-receptor Interaction Serotonin Receptor Activity	Gi/o-coupled Serotonin Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Neurotransmitter Receptor Activity Serotonin Receptor Activity
	Biological Process	Behavioral Fear Response Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Positive Regulation Of Cell Population Proliferation Regulation Of Serotonin Secretion Regulation Of Vasoconstriction Exploration Behavior Regulation Of Dopamine Metabolic Process Serotonin Metabolic Process Regulation Of Hormone Secretion Regulation Of Behavior	Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Intestine Smooth Muscle Contraction Regulation Of Locomotion Vasoconstriction Regulation Of Behavior
Pathways		Serotonin receptors	Serotonin receptors G alpha (i) signalling events
Drugs		Eletriptan Ziprasidone Methysergide Cabergoline Zolmitriptan Dihydroergotamine Amitriptyline Olanzapine Clozapine Loxapine Pramipexole Methylphenidate Imipramine Chlorpromazine Buspirone Haloperidol Nortriptyline Amoxapine Propranolol Fenfluramine Lisuride Trazodone Sumatriptan Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Alprenolol Ondansetron Oxymetazoline Naratriptan Pindolol Dopamine Ergoloid mesylate Doxepin Nefazodone Desipramine Escitalopram Pergolide Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Paliperidone Penbutolol Yohimbine Acepromazine Alverine Molindone Pipotiazine Lysergic acid diethylamide Dapoxetine Bifeprunox Flibanserin Iloperidone Lofexidine Lesopitron Rotigotine MN-305 LI-301 Naluzotan Cariprazine Mianserin Pizotifen Asenapine Xaliproden Dotarizine Sarizotan Repinotan Robalzotan Vilazodone Bopindolol Cinitapride Lurasidone Perospirone Cannabidiol Vortioxetine Brexpiprazole Dosulepin Pirlindole Tianeptine Setiptiline Dihydroergocornine Tetrahydrocannabivarin Pardoprunox Gilteritinib Lecozotan Lecozotan Tiapride Dihydroergocristine Medical Cannabis 5-methoxy-N,N-dimethyltryptamine Nabiximols Aripiprazole lauroxil SEP-363856 Serdexmethylphenidate	Eletriptan Ziprasidone Cabergoline Zolmitriptan Dihydroergotamine Amitriptyline Olanzapine Clozapine Loxapine Fenfluramine Lisuride Sumatriptan Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Almotriptan Oxymetazoline Naratriptan Rizatriptan Frovatriptan Ergoloid mesylate Pergolide Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Paliperidone Yohimbine Lofexidine NXN-188 Setiptiline Dihydroergocornine Gilteritinib Lecozotan Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Adult body size ( 32376654) Alcohol and nicotine co-dependence ( 23216389) Body mass index ( 20935630) Bronchopulmonary dysplasia ( 23897914) Daytime nap ( 33568662) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) White matter lesion progression ( 26451028) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 31015462) Height ( 20881960 28552196) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		8 interacting genes: FGFR1 GABBR2 GNAI3 GPR26 HTR1B HTR1D S1PR1 S1PR3	3 interacting genes: HTR1A HTR1B S1PR1
Entrez ID		3350	3352
HPRD ID		00190	01636
Ensembl ID		ENSG00000178394	ENSG00000179546
Uniprot IDs		A8K5W4 P08908 Q5ZGX3	P28221
PDB IDs		7E2X 7E2Y 7E2Z 8FY8 8FYE 8FYL 8FYT 8FYX 8JSP 8JT6 8PJK 8PKM 8W8B	7E32
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Gi/o-coupled Serotonin Receptor Activity Sphingosine-1-phosphate Receptor Activity Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Signal Transduction G Protein-coupled Serotonin Receptor Activity Serotonin Receptor Activity Sphingosine-1-phosphate Receptor Signaling Pathway Sphingolipid Mediated Signaling Pathway Plasma Membrane Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Signaling Pathway Cell-cell Signaling Vasoconstriction Signaling Cell Communication G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Positive Regulation Of Cell Population Proliferation Cardiac Muscle Tissue Growth Involved In Heart Morphogenesis Cardiac Muscle Tissue Growth Positive Regulation Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Parathyroid Hormone Secretion Trans-synaptic Signaling Synaptic Signaling G Protein-coupled Receptor Binding Regulation Of Behavior Membrane Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Establishment Of Endothelial Barrier Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Regulation Of Lateral Mesodermal Cell Fate Specification Serotonergic Synapse Negative Regulation Of Serotonin Secretion G Protein-coupled GABA Receptor Complex G Protein-coupled GABA Receptor Activity G Protein-coupled Receptor Heterodimeric Complex Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Ventricular Zone Neuroblast Division Regulation Of Mitotic Cell Cycle DNA Replication Orbitofrontal Cortex Development GABA Receptor Complex Sphingolipid Binding Growth Involved In Heart Morphogenesis Positive Regulation Of Chemotaxis	Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Serotonin Secretion Gi/o-coupled Serotonin Receptor Activity Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Serotonin Binding Serotonin Receptor Activity G Protein-coupled Serotonin Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Behavior Positive Regulation Of Smooth Muscle Cell Proliferation G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cardiac Muscle Tissue Growth Involved In Heart Morphogenesis Cardiac Muscle Tissue Growth Regulation Of Smooth Muscle Cell Proliferation Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Blood Vessel Diameter Maintenance Regulation Of Tube Size Serotonergic Synapse Negative Regulation Of Serotonin Secretion Sphingolipid Binding Growth Involved In Heart Morphogenesis System Process Vascular Process In Circulatory System Receptor-receptor Interaction G Protein-coupled Serotonin Receptor Complex Regulation Of Cell Population Proliferation Chemical Synaptic Transmission Circulatory System Process Trans-synaptic Signaling Blood Vessel Maturation Synaptic Signaling Phospholipase C-activating Serotonin Receptor Signaling Pathway Sphingosine-1-phosphate Receptor Activity Regulation Of Monoatomic Ion Transport Serotonin Receptor Signaling Pathway Serotonin Metabolic Process Dendrite Sphingosine-1-phosphate Receptor Signaling Pathway Sphingolipid Mediated Signaling Pathway Bone Remodeling Regulation Of Secretion By Cell Heart Trabecula Morphogenesis Regulation Of Dopamine Metabolic Process Cell-cell Signaling
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