HTR1A and HTR1B

Number of citations of the paper that reports this interaction (PMID 11854302)
10

Data Source:
HPRD (in vitro, in vivo)

		HTR1A	HTR1B
Gene Name		5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Serotonin Receptor Activity Protein Binding	Serotonin Receptor Activity Drug Binding Serotonin Binding
	Biological Process	Behavioral Fear Response G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Cell Proliferation Positive Regulation Of Cell Proliferation Regulation Of Serotonin Secretion Exploration Behavior Regulation Of Dopamine Metabolic Process Vasoconstriction Serotonin Metabolic Process Regulation Of Hormone Secretion Regulation Of Behavior	G-protein Coupled Receptor Internalization G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Regulation Of Dopamine Secretion Negative Regulation Of Serotonin Secretion Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of Synaptic Transmission, GABAergic Cellular Response To Drug Response To Cocaine Vasoconstriction Drinking Behavior Response To Ethanol Bone Remodeling Regulation Of Behavior Response To Mineralocorticoid Negative Regulation Of Synaptic Transmission, Glutamatergic Cellular Response To Alkaloid Cellular Response To Temperature Stimulus
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Serotonin receptors	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Serotonin receptors
Drugs		Eletriptan Ziprasidone Methysergide Cabergoline Ropinirole Zolmitriptan Amitriptyline Olanzapine Clozapine Pramipexole Chlorpromazine Buspirone Nortriptyline Propranolol Lisuride Trazodone Sumatriptan Apomorphine Trimipramine Risperidone Alprenolol Ondansetron Naratriptan Pindolol Ergoloid mesylate Doxepin Nefazodone Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Penbutolol Yohimbine Acepromazine Alverine Molindone Pipotiazine Thioproperazine Iloperidone Rotigotine Asenapine Vilazodone Bopindolol Cinitapride Lurasidone	Eletriptan Ziprasidone Cabergoline Ropinirole Zolmitriptan Dihydroergotamine Olanzapine Clozapine Pramipexole Propranolol Lisuride Sumatriptan Ergotamine Apomorphine Ondansetron Almotriptan Naratriptan Rizatriptan Pindolol Frovatriptan Pergolide Bromocriptine Quetiapine Aripiprazole Yohimbine Asenapine Bopindolol
Diseases
GWAS		Alcohol and nictotine co-dependence ( 23216389) Body mass index ( 20935630)
Protein-Protein Interactions		7 interactors: GABBR2 GNAI3 GPR26 HTR1B HTR1D S1PR1 S1PR3	3 interactors: HTR1A HTR1D MDFI
Entrez ID		3350	3351
HPRD ID		00190	01634
Ensembl ID
Uniprot IDs		A8K5W4 P08908 Q5ZGX3	P28222
PDB IDs			2G1X 4IAQ 4IAR
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Negative Regulation Of Nucleotide Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Sphingosine-1-phosphate Signaling Pathway Serotonin Receptor Signaling Pathway Synaptic Transmission Negative Regulation Of Adenylate Cyclase Activity Regulation Of Behavior Negative Regulation Of Lyase Activity Signal Transduction Vasoconstriction Signaling Cell Communication Cell-cell Signaling Regulation Of Adenylate Cyclase Activity Cellular Response To Stimulus Regulation Of Cyclase Activity Regulation Of Blood Vessel Size Regulation Of Tube Size Cardiac Muscle Tissue Growth Involved In Heart Morphogenesis Negative Regulation Of Establishment Of Endothelial Barrier Cellular Response To Temperature Stimulus Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Response To Stimulus Growth Involved In Heart Morphogenesis Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Serotonin Secretion Intestine Smooth Muscle Contraction Cytosolic Calcium Ion Homeostasis Negative Regulation Of Endothelial Cell Differentiation Regulation Of Serotonin Secretion Drinking Behavior Negative Regulation Of Synaptic Transmission, GABAergic Cellular Calcium Ion Homeostasis Negative Regulation Of Stress Fiber Assembly Calcium Ion Homeostasis Blood Circulation G-protein Coupled Receptor Internalization Negative Regulation Of Actin Filament Bundle Assembly Blood Vessel Maturation Negative Regulation Of Synaptic Transmission, Glutamatergic Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway	Serotonin Receptor Signaling Pathway Vasoconstriction Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Blood Vessel Size Regulation Of Tube Size Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Behavior Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Intestine Smooth Muscle Contraction Blood Circulation Regulation Of Serotonin Secretion Serotonin Metabolic Process Trophoblast Giant Cell Differentiation Regulation Of Dopamine Metabolic Process Cytoplasmic Sequestering Of Transcription Factor Dorsal/ventral Axis Specification Cytoplasmic Sequestering Of Protein Exploration Behavior Cell Differentiation Involved In Embryonic Placenta Development Behavioral Fear Response Activation Of JUN Kinase Activity Fear Response Negative Regulation Of DNA Binding Regulation Of Cellular Localization Negative Regulation Of Transcription Factor Import Into Nucleus G-protein Coupled Receptor Signaling Pathway Smooth Muscle Contraction Positive Regulation Of JUN Kinase Activity Negative Regulation Of Protein Import Into Nucleus Regulation Of JUN Kinase Activity Negative Regulation Of Protein Localization To Nucleus Regulation Of DNA Binding JNK Cascade Signal Transduction Negative Regulation Of Intracellular Protein Transport Multicellular Organismal Response To Stress Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Binding Phenol-containing Compound Metabolic Process Signaling Axis Specification Cell Communication Embryonic Placenta Development Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Intracellular Transport Dorsal/ventral Pattern Formation Positive Regulation Of JNK Cascade Embryonic Skeletal System Morphogenesis
Tagcloud ?		analysing asynchronous chrna5 chrna7 circuit clamp develops earliest ergic grik1 grin2a htr1b innervation kcc2 lmc locomotor medial muscarinic neuromuscular neurotransmitter nicotinic ordered organised patch patterned recordings subtly synchronous transmitter	1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink prkg1 scd1 sfa sorbs1 ufa underling unraveling
Tagcloud (Difference) ?		analysing asynchronous chrna5 chrna7 circuit clamp develops earliest ergic grik1 grin2a innervation kcc2 lmc locomotor medial muscarinic neuromuscular neurotransmitter nicotinic ordered organised patch patterned recordings subtly synchronous transmitter	1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink prkg1 scd1 sfa sorbs1 ufa underling unraveling
Tagcloud (Intersection) ?		htr1b