PON1

Description		paraoxonase 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Extracellular Exosome Blood Microparticle
	Molecular Function	Aryldialkylphosphatase Activity Arylesterase Activity Calcium Ion Binding Phospholipid Binding Hydrolase Activity Protein Homodimerization Activity Metal Ion Binding Acyl-L-homoserine-lactone Lactonohydrolase Activity
	Biological Process	Cholesterol Metabolic Process Response To Toxic Substance Positive Regulation Of Cholesterol Efflux Negative Regulation Of Plasma Lipoprotein Oxidation Carboxylic Acid Catabolic Process Organophosphate Catabolic Process Phosphatidylcholine Metabolic Process Lactone Catabolic Process
Pathways		Synthesis of 5-eicosatetraenoic acids Atorvastatin ADME Atorvastatin ADME
Drugs		Moxifloxacin Cefazolin Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		HDL cholesterol levels ( 32203549) Health literacy ( 31250787) Metabolite levels ( 23281178) Response to TNF antagonist treatment ( 18615156)
Interacting Genes		5 interacting genes: ALB APOA1 CDK1 CLU PLK1
Entrez ID		5444
HPRD ID		01351
Ensembl ID		ENSG00000005421
Uniprot IDs		P27169
PDB IDs		1V04
Enriched GO Terms of Interacting Partners?		Blood Microparticle Spherical High-density Lipoprotein Particle Mitotic Nuclear Membrane Disassembly Reverse Cholesterol Transport Membrane Disassembly Nuclear Membrane Disassembly Protein Localization To Site Of Double-strand Break Mitotic G2 DNA Damage Checkpoint Signaling Chromosome Condensation Spindle Microtubule ERK1 And ERK2 Cascade Regulation Of Protein Stability Regulation Of Organelle Organization Cell Cycle G2/M Phase Transition Nuclear Membrane Organization Centrosome Cycle Mitotic G2/M Transition Checkpoint G2/M Transition Of Mitotic Cell Cycle Platelet Alpha Granule Lumen Cholesterol Transport Negative Regulation Of Cell Cycle G2/M Phase Transition Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Signaling Sterol Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Microtubule Organizing Center Organization Amyloid-beta Binding Pronuclear Fusion Perinuclear Endoplasmic Reticulum Lumen Regulation Of Neuronal Signal Transduction Positive Regulation Of Protein Localization To Nucleus DNA Damage Checkpoint Signaling Protein-folding Chaperone Binding Enterobactin Binding Exogenous Protein Binding Cellular Response To Calcium Ion Starvation Receptor Ligand Activity Intracellular Signal Transduction Protein Localization To Organelle Protein Localization To Chromosome Mitotic DNA-templated DNA Replication Golgi Organization Regulation Of G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Sister Chromatid Segregation Cyclin B1-CDK1 Complex Regulation Of Chromosome Segregation Membrane Organization Cyclin A1-CDK1 Complex
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