PON1

Gene Name		paraoxonase 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Aryldialkylphosphatase Activity Arylesterase Activity Calcium Ion Binding Phospholipid Binding Protein Homodimerization Activity
	Biological Process	Response To External Stimulus Response To Toxic Substance Positive Regulation Of Cholesterol Efflux Dephosphorylation Aromatic Compound Catabolic Process Response To Nutrient Levels Positive Regulation Of Transporter Activity Negative Regulation Of Plasma Lipoprotein Particle Oxidation Carboxylic Acid Catabolic Process Organophosphate Catabolic Process Phosphatidylcholine Metabolic Process Positive Regulation Of Binding Response To Fatty Acid Response To Fluoride
Pathways
Drugs		Cefazolin
Diseases
GWAS		Metabolite levels ( 23281178) Response to TNF antagonist treatment ( 18615156)
Protein-protein Interactions		3 interactors: ALB APOA1 CLU
Entrez ID		5444
HPRD ID		01351
Ensembl ID
Uniprot IDs		P27169
PDB IDs		1V04 1XHR
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Platelet Activation Reverse Cholesterol Transport Lipid Transport Lipid Localization Exocytosis Blood Coagulation Hemostasis Secretion By Cell Regulation Of Body Fluid Levels Wound Healing Secretion Sterol Transport Cholesterol Transport Cell Activation Response To Wounding Protein Stabilization Regulation Of Protein Stability Negative Regulation Of Cell Adhesion Molecule Production Positive Regulation Of Tau-protein Kinase Activity Microglial Cell Proliferation Regulation Of Neuronal Signal Transduction Lipoprotein Metabolic Process Lipid Metabolic Process Vesicle-mediated Transport Maintenance Of Mitochondrion Location Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Interleukin-1 Beta Secretion Response To Nutrient Steroid Metabolic Process Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Cholesterol Import Response To Platinum Ion Hemolysis By Symbiont Of Host Erythrocytes Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Central Nervous System Myelin Maintenance Negative Regulation Of Interleukin-1 Secretion Response To External Stimulus Positive Regulation Of Cellular Component Biogenesis Cellular Component Assembly Regulation Of Tau-protein Kinase Activity Establishment Of Localization In Cell Receptor-mediated Endocytosis Negative Regulation Of Protein Homooligomerization High-density Lipoprotein Particle Clearance Positive Regulation Of Inclusion Body Assembly Regulation Of Beta-amyloid Clearance Protein Oxidation Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Cytokine Secretion Involved In Immune Response
Tagcloud ?		admission apoa1 atherosclerosis believed concentration consequence controls explain explanation explicable fifth genotypes hdl immediately infarction mi microg min ml myocardial nmol occured paraoxonase reside risen subfraction subgroups thrombolytic variation