PON1 and ALB

Number of citations of the paper that reports this interaction (PMID 6324579)
12

Data Source:
HPRD (in vitro)

		PON1	ALB
Gene Name		paraoxonase 1	albumin
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Basement Membrane Extracellular Space Nucleus Platelet Alpha Granule Lumen Protein Complex Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Aryldialkylphosphatase Activity Arylesterase Activity Calcium Ion Binding Phospholipid Binding Protein Homodimerization Activity	DNA Binding Fatty Acid Binding Copper Ion Binding Protein Binding Drug Binding Zinc Ion Binding Toxic Substance Binding Antioxidant Activity Oxygen Binding Enzyme Binding Pyridoxal Phosphate Binding Chaperone Binding
	Biological Process	Response To External Stimulus Response To Toxic Substance Positive Regulation Of Cholesterol Efflux Dephosphorylation Aromatic Compound Catabolic Process Response To Nutrient Levels Positive Regulation Of Transporter Activity Negative Regulation Of Plasma Lipoprotein Particle Oxidation Carboxylic Acid Catabolic Process Organophosphate Catabolic Process Phosphatidylcholine Metabolic Process Positive Regulation Of Binding Response To Fatty Acid Response To Fluoride	Retina Homeostasis Platelet Degranulation Transport Receptor-mediated Endocytosis Response To Nutrient Blood Coagulation Bile Acid Metabolic Process Cellular Response To Starvation Response To Organic Substance Bile Acid And Bile Salt Transport Hemolysis By Symbiont Of Host Erythrocytes Platelet Activation Lipoprotein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Sodium-independent Organic Anion Transport Small Molecule Metabolic Process Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Response To Mercury Ion Maintenance Of Mitochondrion Location Transmembrane Transport Response To Platinum Ion
Pathways			Lipoprotein metabolism Bile acid and bile salt metabolism Metabolism of lipids and lipoproteins Recycling of bile acids and salts Platelet degranulation Lipid digestion, mobilization, and transport Transport of organic anions SLC-mediated transmembrane transport HDL-mediated lipid transport Scavenging of heme from plasma Response to elevated platelet cytosolic Ca2+ Platelet activation, signaling and aggregation Transport of vitamins, nucleosides, and related molecules
Drugs		Cefazolin
Diseases
GWAS		Metabolite levels ( 23281178) Response to TNF antagonist treatment ( 18615156)	Lipid metabolism phenotypes ( 22286219) Prostate cancer ( 23535732)
Protein-Protein Interactions		3 interactors: ALB APOA1 CLU	24 interactors: AGA AMBP APOE APP CRYAA CUBN F7 FCGRT HNF1A IMMT KLK3 LRP2 LUC7L2 NR5A2 ORM1 PFDN1 PON1 PRB3 RBP4 RYR2 SRGN ST13 TK1 YWHAG
Entrez ID		5444	213
HPRD ID		01351	00062
Ensembl ID			ENSG00000163631
Uniprot IDs		P27169	C9JKR2 P02768
PDB IDs		1V04 1XHR	1AO6 1BJ5 1BKE 1BM0 1E78 1E7A 1E7B 1E7C 1E7E 1E7F 1E7G 1E7H 1E7I 1GNI 1GNJ 1H9Z 1HA2 1HK1 1HK2 1HK3 1HK4 1HK5 1N5U 1O9X 1TF0 1UOR 1YSX 2BX8 2BXA 2BXB 2BXC 2BXD 2BXE 2BXF 2BXG 2BXH 2BXI 2BXK 2BXL 2BXM 2BXN 2BXO 2BXP 2BXQ 2ESG 2I2Z 2I30 2VDB 2VUE 2VUF 2XSI 2XVQ 2XVU 2XVV 2XVW 2XW0 2XW1 2YDF 3A73 3B9L 3B9M 3CX9 3JQZ 3JRY 3LU6 3LU7 3LU8 3SQJ 3TDL 3UIV 4E99 4EMX 4G03 4G04 4HGK 4HGM 4IW1 4IW2 4K2C 4L8U 4L9K 4L9Q 4LA0 4LB2 4LB9
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Platelet Activation Reverse Cholesterol Transport Lipid Transport Lipid Localization Exocytosis Blood Coagulation Hemostasis Secretion By Cell Regulation Of Body Fluid Levels Wound Healing Secretion Sterol Transport Cholesterol Transport Cell Activation Response To Wounding Protein Stabilization Regulation Of Protein Stability Negative Regulation Of Cell Adhesion Molecule Production Positive Regulation Of Tau-protein Kinase Activity Microglial Cell Proliferation Regulation Of Neuronal Signal Transduction Lipoprotein Metabolic Process Lipid Metabolic Process Vesicle-mediated Transport Maintenance Of Mitochondrion Location Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Interleukin-1 Beta Secretion Response To Nutrient Steroid Metabolic Process Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Cholesterol Import Response To Platinum Ion Hemolysis By Symbiont Of Host Erythrocytes Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Central Nervous System Myelin Maintenance Negative Regulation Of Interleukin-1 Secretion Response To External Stimulus Positive Regulation Of Cellular Component Biogenesis Cellular Component Assembly Regulation Of Tau-protein Kinase Activity Establishment Of Localization In Cell Receptor-mediated Endocytosis Negative Regulation Of Protein Homooligomerization High-density Lipoprotein Particle Clearance Positive Regulation Of Inclusion Body Assembly Regulation Of Beta-amyloid Clearance Protein Oxidation Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Cytokine Secretion Involved In Immune Response	Alcohol Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Chemical Homeostasis Lipid Metabolic Process Homeostatic Process Response To External Stimulus Response To Stimulus Phototransduction, Visible Light Retinoid Metabolic Process Tetrapyrrole Metabolic Process Vitamin D Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Regulation Of Blood Coagulation Response To Lipid Positive Regulation Of Cholesterol Efflux Reverse Cholesterol Transport Detection Of Light Stimulus Positive Regulation Of Cholesterol Transport Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis System Development Isoprenoid Metabolic Process Small Molecule Metabolic Process Regulation Of Cholesterol Efflux Response To Hormone Regulation Of Wound Healing Organ Development Response To Light Stimulus Vesicle-mediated Transport Receptor-mediated Endocytosis Endocytosis Regulation Of Cellular Localization Response To Organic Substance Response To Wounding Response To Abiotic Stimulus Cellular Metal Ion Homeostasis Positive Regulation Of Transport Bile Acid Metabolic Process Detection Of Abiotic Stimulus Regulation Of Cholesterol Transport Blood Coagulation Tissue Homeostasis Hemostasis Response To Nutrient Levels Heme Metabolic Process Multicellular Organismal Development
Tagcloud ?		admission apoa1 atherosclerosis believed concentration consequence controls explain explanation explicable fifth genotypes hdl immediately infarction mi microg min ml myocardial nmol occured paraoxonase reside risen subfraction subgroups thrombolytic variation	ambulatory anabolic anthropometric calls capd catabolism causal complicating declined deterioration dialysis haemodialysis instead malnutrition mmol nutrineal nutrition osmotic peritoneal phosphates phosphorus rule solution substituted termination transferrin uraemic urea wilcoxon
Tagcloud (Difference) ?		admission apoa1 atherosclerosis believed concentration consequence controls explain explanation explicable fifth genotypes hdl immediately infarction mi microg min ml myocardial nmol occured paraoxonase reside risen subfraction subgroups thrombolytic variation	ambulatory anabolic anthropometric calls capd catabolism causal complicating declined deterioration dialysis haemodialysis instead malnutrition mmol nutrineal nutrition osmotic peritoneal phosphates phosphorus rule solution substituted termination transferrin uraemic urea wilcoxon
Tagcloud (Intersection) ?