APBB2 and TRADD

Number of citations of the paper that reports this interaction (PubMedID 17567906)
45

Data Source:
BioGRID (two hybrid)

		APBB2	TRADD
Description		amyloid beta precursor protein binding family B member 2	TNFRSF1A associated via death domain
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Early Endosome Endoplasmic Reticulum Golgi Apparatus Membrane Lamellipodium Growth Cone Synapse	Tumor Necrosis Factor Receptor Superfamily Complex Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Death-inducing Signaling Complex Receptor Complex
	Molecular Function	Amyloid-beta Binding Protein Binding Molecular Adaptor Activity	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Kinase Binding Protein-macromolecule Adaptor Activity Signaling Adaptor Activity Identical Protein Binding Molecular Adaptor Activity Death Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Regulation Of DNA-templated Transcription Smooth Muscle Contraction Axon Guidance Extracellular Matrix Organization Intracellular Signal Transduction Maintenance Of Lens Transparency Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Synapse Organization Negative Regulation Of Cell Cycle Phase Transition	Apoptotic Process Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Canonical NF-kappaB Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Cell Migration Tumor Necrosis Factor-mediated Signaling Pathway TRAIL-activated Apoptotic Signaling Pathway Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Inflammatory Response Positive Regulation Of Hair Follicle Development Cellular Response To Tumor Necrosis Factor Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway
Pathways			Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Regulation of necroptotic cell death Dimerization of procaspase-8 TNF signaling Defective RIPK1-mediated regulated necrosis
Drugs
Diseases
GWAS		Dental caries ( 23259602) Glaucoma (primary open-angle) ( 31688885) Height ( 28552196) Iris color (L* coordinate) ( 29109912) Opioid sensitivity ( 24143882) Response to citalopram or escitalopram in depression ( 27622933) Severe insulin-resistant type 2 diabetes ( 34737425)
Interacting Genes		9 interacting genes: APLP2 APP MAPK8 NFKB1 SMAD4 SMURF1 TP53 TRADD WWOX	24 interacting genes: APBB2 BCL10 BIRC2 CNTRL DAPK1 FADD FAS HIPK2 KRT14 KRT18 NGFR PPP2R1A RIPK1 STAT1 TMC8 TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF21 TNFRSF25 TRAF1 TRAF2 TRAF3 TRPC4AP
Entrez ID		323	8717
HPRD ID		04088	04610
Ensembl ID		ENSG00000163697	ENSG00000102871
Uniprot IDs		B4DJ88 B4E2F2 G5E9Y1 Q5I0G1 Q92870	Q15628
PDB IDs			1F2H 1F3V 5XME 6AC0 7CSQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of MiRNA Metabolic Process Cell Surface Receptor Signaling Pathway Intracellular Signaling Cassette Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Transcription Coactivator Binding Histone Deacetylase Regulator Activity Signal Transduction Identical Protein Binding Intracellular Signal Transduction Positive Regulation Of MiRNA Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of MiRNA Transcription Regulation Of Wnt Signaling Pathway Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cardiac Muscle Cell Apoptotic Process I-SMAD Binding Enzyme Binding Transition Metal Ion Binding Platelet Alpha Granule Apoptotic Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway Central Nervous System Development Programmed Cell Death Positive Regulation Of Apoptotic Signaling Pathway Cell Death Regulation Of Hair Follicle Development Protein Serine/threonine Kinase Binding Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Chromatin Binding Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Inflammatory Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of RNA Metabolic Process Molecular Function Activator Activity R-SMAD Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Hair Cycle Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Cellular Component Organization Non-canonical NF-kappaB Signal Transduction Response To Mechanical Stimulus Regulation Of Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process	Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Apoptotic Process Cell Death Programmed Cell Death Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Canonical NF-kappaB Signal Transduction Cytokine-mediated Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Tumor Necrosis Factor Receptor Binding Cellular Response To Mechanical Stimulus Positive Regulation Of Apoptotic Signaling Pathway Signaling Adaptor Activity Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Death Receptor Activity Response To Mechanical Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Death-inducing Signaling Complex Tumor Necrosis Factor Binding Negative Regulation Of Apoptotic Process Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Lymphocyte Apoptotic Process Necroptotic Signaling Pathway TRAIL-activated Apoptotic Signaling Pathway Tumor Necrosis Factor Receptor Activity Thioesterase Binding CD40 Receptor Complex Neuron Apoptotic Process Leukocyte Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Signaling Receptor Activity Negative Regulation Of Necroptotic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Programmed Necrotic Cell Death Negative Regulation Of Programmed Necrotic Cell Death
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