HSPD1 and SIRT3

Number of citations of the paper that reports this interaction (PMID 21840382)
2

Data Source:
BioGRID (pull down)

		HSPD1	SIRT3
Gene Name		heat shock 60kDa protein 1 (chaperonin)	sirtuin 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Early Endosome Cytosol Plasma Membrane Coated Pit Cell Surface Membrane Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex Coated Vesicle Secretory Granule Protein Complex Lipopolysaccharide Receptor Complex Extracellular Vesicular Exosome	Mitochondrion Mitochondrial Matrix Membrane
	Molecular Function	Lipopolysaccharide Binding P53 Binding DNA Replication Origin Binding Single-stranded DNA Binding Double-stranded RNA Binding Protein Binding ATP Binding ATPase Activity Ubiquitin Protein Ligase Binding Poly(A) RNA Binding Unfolded Protein Binding Chaperone Binding	NAD+ ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding Enzyme Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) NAD+ Binding
	Biological Process	B Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell 'de Novo' Protein Folding Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Unfolded Protein Viral Process Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Protein Refolding B Cell Proliferation T Cell Activation B Cell Activation Positive Regulation Of Macrophage Activation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Isotype Switching To IgG Isotypes Protein Stabilization Positive Regulation Of T Cell Activation Chaperone-mediated Protein Complex Assembly Protein Maturation	Protein ADP-ribosylation Protein Deacetylation Organelle Organization Mitochondrion Organization Aging Aerobic Respiration Peptidyl-lysine Deacetylation Histone H3 Deacetylation
Pathways		Mitochondrial protein import	Organelle biogenesis and maintenance Transcriptional activation of mitochondrial biogenesis Mitochondrial biogenesis
Drugs
Diseases
GWAS			Uterine fibroids ( 21460842)
Protein-Protein Interactions		40 interactors: ALDH2 APP BAK1 BRCA1 CA2 CASP3 CASP9 CEP70 CLEC7A CLU DHFR ERG FHIT HIST2H2BE HSPE1 ITGA3 ITGB1 KRT31 KRT40 KRTAP10-3 KRTAP10-8 KRTAP5-9 LRRK2 LZTS2 MAPK6 NOTCH2NL NR3C1 PLG PPP2R1A PPP2R1B PRKACA PRNP RASA1 RGS20 SAMD3 SIRT3 SUMO4 TLR1 TMCC2 YWHAG	4 interactors: DNM1L HSPD1 PEX5 XRCC6
Entrez ID		3329	23410
HPRD ID		00318	06836
Ensembl ID		ENSG00000144381	ENSG00000142082
Uniprot IDs		P10809	E9PK80 E9PM75 E9PN58 Q9NTG7
PDB IDs			3GLR 3GLS 3GLT 3GLU 4BN4 4BN5 4BV3 4BVB 4BVE 4BVF 4BVG 4BVH 4FVT 4FZ3 4HD8 4JSR 4JT8 4JT9
Enriched GO Terms of Interacting Partners?		Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Death Cell Death Regulation Of Cell Death Death Apoptotic Process Positive Regulation Of Apoptotic Process Programmed Cell Death Developmental Process Response To Organic Substance Negative Regulation Of Signal Transduction Negative Regulation Of Protein Metabolic Process Apoptotic Signaling Pathway Response To Stimulus Negative Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Signaling Negative Regulation Of Cellular Protein Metabolic Process Cell Communication Signal Transduction Positive Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Negative Regulation Of Protein Phosphorylation Regulation Of Proteolysis Regulation Of Signal Transduction Cellular Response To Stimulus Positive Regulation Of Protein Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Intracellular Signal Transduction Cell Differentiation Cell Cycle Process Negative Regulation Of Phosphorylation Response To Stress Mitotic Cell Cycle Phase Transition Regulation Of Protein Phosphorylation Cell Cycle Phase Transition Cell Cycle Anatomical Structure Development Regulation Of Cell Adhesion Positive Regulation Of Peptidase Activity Positive Regulation Of Cellular Protein Metabolic Process Response To Radiation Anatomical Structure Morphogenesis Positive Regulation Of Neuron Death Regulation Of Neuron Death Response To Organic Cyclic Compound	Regulation Of Protein Oligomerization Peroxisome Organization Positive Regulation Of Type I Interferon Production Regulation Of Type I Interferon Production Protein Tetramerization Mitochondrial Membrane Fission B Cell Cytokine Production Dynamin Polymerization Involved In Mitochondrial Fission Isotype Switching To IgG Isotypes Protein Complex Assembly Negative Regulation Of Protein Homotetramerization Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Protein Import Into Peroxisome Matrix, Translocation Cellular Hyperosmotic Salinity Response Regulation Of Peroxisome Organization DNA Recombination Protein Import Into Peroxisome Matrix, Docking Cellular Response To X-ray Negative Regulation Of Protein Homooligomerization Regulation Of Protein Complex Assembly Protein Import Into Peroxisome Membrane Protein To Membrane Docking Establishment Of Integrated Proviral Latency Cellular Protein Complex Assembly Positive Regulation Of Cytokine Production Peroxisomal Membrane Transport Positive Regulation Of Immune Response To Tumor Cell Cellular Hyperosmotic Response Positive Regulation Of Mitochondrial Fission Hyperosmotic Salinity Response Mitochondrial Fragmentation Involved In Apoptotic Process Negative Regulation Of Protein Oligomerization Establishment Of Viral Latency Mitochondrion Organization Anatomical Structure Development Peroxisome Fission Cellular Response To Salt Stress Positive Regulation Of Macrophage Activation Protein Oligomerization Cellular Component Assembly Regulation Of Mitochondrial Fission Chaperone-mediated Protein Complex Assembly Protein Import Into Peroxisome Matrix Cytokine Production Involved In Immune Response DNA Ligation Protein Localization To Organelle Developmental Process Regulation Of Cytokine Production Positive Regulation Of Interferon-alpha Production Viral Process
Tagcloud ?		5d achieved complicated contributed dimerization earliest endogenous enhanced facilitated heat hsp60 ifn ikkepsilon induction interacted interacting interferon irf3 knockdown mavs mda mock phosphorylated progress protective rig sev shock tbk1	acceptable aging alternating ameliorate antioxidant blinded caloric crossover diet dietary dieting diets extend fasting feasting intermittent lifespan marginal paradigm restriction sirtuins strict supplementation sustainable tolerability tolerable upregulate uu vitamins
Tagcloud (Difference) ?		5d achieved complicated contributed dimerization earliest endogenous enhanced facilitated heat hsp60 ifn ikkepsilon induction interacted interacting interferon irf3 knockdown mavs mda mock phosphorylated progress protective rig sev shock tbk1	acceptable aging alternating ameliorate antioxidant blinded caloric crossover diet dietary dieting diets extend fasting feasting intermittent lifespan marginal paradigm restriction sirtuins strict supplementation sustainable tolerability tolerable upregulate uu vitamins
Tagcloud (Intersection) ?