HSPA4 and BAG5

Number of citations of the paper that reports this interaction (PMID 15603737)
30

Data Source:
BioGRID (pull down)

		HSPA4	BAG5
Gene Name		heat shock 70kDa protein 4	BCL2-associated athanogene 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Cytosol Extracellular Vesicular Exosome	Nucleus Mitochondrion Membrane Inclusion Body Perinuclear Region Of Cytoplasm
	Molecular Function	ATP Binding	Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Chaperone Binding
	Biological Process	Response To Unfolded Protein Protein Import Into Mitochondrial Outer Membrane Chaperone-mediated Protein Complex Assembly	Protein Folding Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Refolding Neuron Death Regulation Of Inclusion Body Assembly Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		58 interactors: AGTRAP APPBP2 BAG1 BAG2 BAG5 BRMS1 CALM1 CD40 CDC73 CDKN2A CSNK1A1 CSNK2A1 DDIT4 DNAJB1 DUSP1 EGFR ESR1 FANCC FES FKBP4 GATA1 GRPEL2 GSK3B GZMA HAP1 HDAC3 HNRNPD HSPBP1 IKBKG KPNA2 KRT18 MAPT NFKB1 NR3C2 OLR1 PHLDA1 PPP1CA PRKCB PRKCD PRKCG PRSS23 PSMD10 RAF1 REL RELA SMAD3 SOD1 ST13 STIP1 STUB1 SUGT1 TERT TIMM44 TOMM40 TRAF6 TTC1 UBE2L3 UBE3A	12 interactors: BANP CCDC155 CIRBP FAM118B HSPA4 LRRK2 MAD1L1 PARK2 SNCA STUB1 THAP1 TRIM27
Entrez ID		3308	9529
HPRD ID		09025	04862
Ensembl ID			ENSG00000166170
Uniprot IDs		P34932	Q9UL15
PDB IDs			2D9D 3A8Y
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Cellular Response To Organic Substance Negative Regulation Of Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Protein Metabolic Process Response To Organic Substance Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Cell Death Death Neurotrophin Signaling Pathway Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Negative Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Stress Cellular Response To Growth Factor Stimulus Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Apoptotic Process Response To Growth Factor Cellular Response To Stimulus Programmed Cell Death Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Negative Regulation Of Signal Transduction Cellular Metabolic Process Signaling Response To Stimulus Cell Communication Regulation Of Metabolic Process Negative Regulation Of Signaling Positive Regulation Of Cell Death Cellular Protein Metabolic Process Signal Transduction Regulation Of Protein Phosphorylation Immune System Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death	Negative Regulation Of Protein Metabolic Process Cellular Response To Catecholamine Stimulus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein K63-linked Ubiquitination Regulation Of Protein Catabolic Process Cellular Response To Dopamine Dopamine Uptake Involved In Synaptic Transmission Organelle Organization Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Synaptic Vesicle Transport Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Response To Oxidative Stress Cellular Response To Manganese Ion Regulation Of Neurotransmitter Secretion Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Protein Localization To Mitochondrion Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Negative Regulation Of Protein Phosphorylation Response To Ammonium Ion Dopamine Transport Regulation Of Mitochondrial Fission Neurotransmitter Uptake Synaptic Transmission, Dopaminergic Response To Stress Mitochondrion Organization Negative Regulation Of Transport Negative Regulation Of Phosphorylation Cellular Response To Metal Ion Cellular Localization Response To Unfolded Protein Positive Regulation Of Protein Ubiquitination Regulation Of Organelle Organization Response To Manganese Ion Cellular Response To Inorganic Substance Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Dopamine Secretion Cellular Response To Ammonium Ion Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Secretion By Cell Regulation Of Cellular Localization Protein Polyubiquitination Negative Regulation Of Oxidoreductase Activity Protein Localization To Organelle Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Monoamine Transport Negative Regulation Of Secretion
Tagcloud ?		competence cumulus damaged domestic fertility hfs2 hsf hsf1 hsp110 hsp40 hsp90a hsp90b hsph1 hsps machinery oocyte oocytes operational ovaries ovary pig preserve sows summer unexpectedly warm winter	athanogene compacta decreasing familial interacted mitochondria mptp nigra null park6 parkinson parkinsonism pars pink1 predominantly preventing proteasome pten pull rescued rotenone snpc sporadic stabilize stabilized substantia ubiquitination ups
Tagcloud (Difference) ?		competence cumulus damaged domestic fertility hfs2 hsf hsf1 hsp110 hsp40 hsp90a hsp90b hsph1 hsps machinery oocyte oocytes operational ovaries ovary pig preserve sows summer unexpectedly warm winter	athanogene compacta decreasing familial interacted mitochondria mptp nigra null park6 parkinson parkinsonism pars pink1 predominantly preventing proteasome pten pull rescued rotenone snpc sporadic stabilize stabilized substantia ubiquitination ups
Tagcloud (Intersection) ?