UPK2 and ZNRF4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UPK2	ZNRF4
Description		uroplakin 2	zinc and ring finger 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Membrane Organelle Membrane
	Molecular Function	Protein Binding	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Epithelial Cell Differentiation	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Defense Response To Bacterium Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Negative Regulation Of Intracellular Signal Transduction
Pathways
Drugs
Diseases
GWAS		Asthma ( 31959851)
Interacting Genes		36 interacting genes: ADGRG3 AMIGO1 ASGR2 ATP6AP2 BSCL2 BTNL9 C3orf52 CD74 CLDN7 CLEC17A CLEC7A CYB5R3 FCGR1A FCGR2A FCGRT FKBP7 FNDC9 GPA33 HPN ITM2C KASH5 KIR2DL3 KIR3DL3 LIME1 PLP1 RNF170 SLC18A1 SLC22A23 SMAGP STOML3 TMEM106C TMPRSS2 TNFSF11 TNFSF14 UPK1A ZNRF4	13 interacting genes: NT5E RIPK2 TPRX1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2G2 UBE2N UBE2W UPK2
Entrez ID		7379	148066
HPRD ID		10295	15895
Ensembl ID		ENSG00000110375	ENSG00000105428
Uniprot IDs		O00526	Q8WWF5
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Immune Response-regulating Signaling Pathway External Side Of Plasma Membrane Immune System Process IgG Binding Immune Response Regulation Of Immune Response Regulation Of Immune System Process IgG Receptor Activity Regulation Of Non-canonical NF-kappaB Signal Transduction Pattern Recognition Receptor Activity Immunoglobulin Mediated Immune Response Fucose Binding B Cell Mediated Immunity Antibody-dependent Cellular Cytotoxicity Protein Binding Positive Regulation Of Immune System Process Endoplasmic Reticulum Endoplasmic Reticulum Membrane Hypersensitivity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Phagocytosis, Recognition Positive Regulation Of Immune Response Positive Regulation Of Viral Entry Into Host Cell Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Phagocytosis Acute Inflammatory Response To Antigenic Stimulus Immune Response-activating Signaling Pathway Regulation Of Viral Entry Into Host Cell D-mannose Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Viral Life Cycle Regulation Of Phagocytosis Positive Regulation Of Acute Inflammatory Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Tumor Necrosis Factor Production MHC Class II Protein Binding, Via Antigen Binding Groove NOS2-CD74 Complex Macrophage Migration Inhibitory Factor Signaling Pathway Lymphocyte Mediated Immunity Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production High-affinity IgG Receptor Activity IgG Immunoglobulin Transcytosis In Epithelial Cells Mediated By FcRn Immunoglobulin Receptor Tumor Necrosis Factor Receptor Binding Eye Pigmentation Activation Of Immune Response Detection Of Yeast Detection Of Molecule Of Fungal Origin	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Monoubiquitination Nucleotide Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process ATP Binding Proteolysis Involved In Protein Catabolic Process Protein Modification Process Protein K11-linked Ubiquitination Transferase Activity Catabolic Process Macromolecule Catabolic Process Positive Regulation Of Protein Polyubiquitination Proteolysis Regulation Of Protein Polyubiquitination Protein Metabolic Process TORC1 Signaling Positive Regulation Of Protein K63-linked Ubiquitination Negative Regulation Of TORC1 Signaling Proteasomal Protein Catabolic Process Protein K63-linked Ubiquitination TOR Signaling Macromolecule Metabolic Process Negative Regulation Of TOR Signaling Regulation Of Protein K63-linked Ubiquitination Regulation Of TORC1 Signaling Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K6-linked Ubiquitination Regulation Of TOR Signaling Regulation Of Protein Ubiquitination Nucleoplasm Regulation Of Post-translational Protein Modification Adenosine Biosynthetic Process Cellular Response To Nutrient Levels Negative Regulation Of BMP Signaling Pathway Protein Autoubiquitination Maternal-to-zygotic Transition Of Gene Expression Antiviral Innate Immune Response DNA Metabolic Process Negative Regulation Of Intracellular Signal Transduction Protein-containing Complex
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