HPD and HRSP12

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		HPD	HRSP12
Gene Name		4-hydroxyphenylpyruvate dioxygenase	heat-responsive protein 12
Image
Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome	Nucleus Cytoplasm Mitochondrion Extracellular Vesicular Exosome
	Molecular Function	4-hydroxyphenylpyruvate Dioxygenase Activity Metal Ion Binding	Endonuclease Activity Deaminase Activity Poly(A) RNA Binding
	Biological Process	L-phenylalanine Catabolic Process Tyrosine Catabolic Process Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process	Regulation Of Translational Termination Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Phenylalanine and tyrosine catabolism Metabolism of amino acids and derivatives
Drugs		Nitisinone (1-Tert-Butyl-5-Hydroxy-1h-Pyrazol-4-Yl)-(6-Methanesulfonyl-4\'-Methoxy-2-Methyl-Biphenyl-3-Yl)-Methanone	Benzoic Acid
Diseases
GWAS		Obesity-related traits ( 23251661) Urinary metabolites ( 21572414)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		4 interactors: CDKN1A HIVEP1 HRSP12 IKBKG	9 interactors: COX2 DEAF1 HIVEP1 HPD MDM2 SERPINA5 SPEN TMEM176A TRIB3
Entrez ID		3242	10247
HPRD ID		02041	03924
Ensembl ID		ENSG00000158104	ENSG00000132541
Uniprot IDs		P32754	P52758
PDB IDs		3ISQ	1ONI
Enriched GO Terms of Interacting Partners?		Fc-epsilon Receptor Signaling Pathway Fc Receptor Signaling Pathway Intestinal Epithelial Cell Maturation Cellular Response To UV-B Immune Response-regulating Cell Surface Receptor Signaling Pathway Stress-induced Premature Senescence Regulation Of Gene Expression Regulation Of Translational Termination Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Kinase Activity Mitotic Cell Cycle Arrest Response To UV-B Intestinal Epithelial Cell Development Regulation Of Protein Metabolic Process Regulation Of Protein Import Into Nucleus, Translocation Positive Regulation Of Transferase Activity Intestinal Epithelial Cell Differentiation Epithelial Cell Maturation Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity Response To Arsenic-containing Substance Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cellular Senescence Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of NIK/NF-kappaB Signaling Response To X-ray Positive Regulation Of Protein Phosphorylation Response To Hyperoxia Regulation Of Protein Kinase Activity Response To Corticosterone B Cell Homeostasis Regulation Of Kinase Activity NIK/NF-kappaB Signaling Response To Mineralocorticoid Regulation Of NIK/NF-kappaB Signaling Innate Immune Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of B Cell Proliferation Cellular Response To DNA Damage Stimulus Positive Regulation Of Phosphorylation Regulation Of Immune Response Columnar/cuboidal Epithelial Cell Development Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of DNA Biosynthetic Process Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Fatty Acid Biosynthetic Process Response To Light Stimulus Cellular Response To UV Maintenance Of Blood-brain Barrier Cellular Response To UV-C Cellular Response To Vitamin B1 Regulation Of Fatty Acid Metabolic Process Response To Radiation Cellular Response To Light Stimulus Cellular Response To Organonitrogen Compound Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Response To Vitamin Positive Regulation Of Nucleocytoplasmic Transport Cellular Response To Oxygen Levels Defense Response Regulation Of Fat Cell Differentiation Positive Regulation Of Fibroblast Growth Factor Production Response To UV Regulation Of Lipid Biosynthetic Process Phosphatidylinositol-mediated Signaling Learning Cellular Response To Radiation Positive Regulation Of Cellular Metabolic Process Gamete Generation Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of Synaptic Transmission, Dopaminergic Nicotinamide Metabolic Process Positive Regulation Of Platelet-derived Growth Factor Production Positive Regulation Of Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Cell Differentiation Tyrosine Catabolic Process Response To Vitamin B1 Response To Ether Negative Regulation Of Dendritic Cell Differentiation Response To Carbohydrate Positive Regulation Of Brown Fat Cell Differentiation Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Tagcloud ?		agers agricultural compliance conduct conservation describes educational eighty farm feasible greatest hcp hearing hpds industrial intention junior loud multicomponent noise persuade school schools senior students surveys teen working yearly
Tagcloud (Difference) ?		agers agricultural compliance conduct conservation describes educational eighty farm feasible greatest hcp hearing hpds industrial intention junior loud multicomponent noise persuade school schools senior students surveys teen working yearly
Tagcloud (Intersection) ?