HPD and STK33

Number of citations of the paper that reports this interaction (PubMedID 31537781)
38

Data Source:
BioGRID (enzymatic study)

		HPD	STK33
Description		4-hydroxyphenylpyruvate dioxygenase	serine/threonine kinase 33
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Extracellular Exosome	Manchette Nucleus Cytoplasm Cytoskeleton Perinuclear Region Of Cytoplasm
	Molecular Function	4-hydroxyphenylpyruvate Dioxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Protein Homodimerization Activity Metal Ion Binding Dioxygenase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	L-phenylalanine Catabolic Process L-tyrosine Catabolic Process Aromatic Amino Acid Metabolic Process	Spermatogenesis Cell Differentiation Mitotic DNA Damage Checkpoint Signaling Protein Autophosphorylation Manchette Assembly
Pathways		Tyrosine catabolism
Drugs		Nitisinone DAS869	Fostamatinib
Diseases		Tyrosinemia; Tyrosinemia, type I; Tyrosinemia, type II; Tyrosinemia, type III; Hawkinsinuria
GWAS		HDL cholesterol levels ( 32203549) Obesity-related traits ( 23251661) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolites ( 21572414 26352407)	Adult body size ( 32376654) Body mass index ( 19079261 26426971 28448500 28892062) Body mass index (age <50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body mass index x sex x age interaction (4df test) ( 26426971) Fruit consumption ( 32066663) Intake of total sugars ( 31005972) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Small cell lung carcinoma ( 28604730)
Interacting Genes		5 interacting genes: CDKN1A HIVEP1 IKBKG RIDA STK33	5 interacting genes: APP GLYCTK HPD USP15 USP5
Entrez ID		3242	65975
HPRD ID		02041	09642
Ensembl ID		ENSG00000158104	ENSG00000130413
Uniprot IDs		P32754	B3KS39 B4DDH2 F8WAK5 Q9BYT3
PDB IDs		3ISQ 5EC3 8IM2 8IM3	8VF6
Enriched GO Terms of Interacting Partners?		Cell Cycle G1/S Phase Transition Positive Regulation Of Fibroblast Proliferation Cyclin Binding DNA Damage Response G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Cyclin D2-CDK6 Complex Cyclin-dependent Protein Kinase Holoenzyme Complex Mitotic DNA Integrity Checkpoint Signaling Mitotic DNA Damage Checkpoint Signaling 2-iminopropanoate Deaminase Activity 2-iminobutanoate/2-iminopropanoate Deaminase L-threonine Catabolic Process To Glycine RNA Endonuclease Activity Producing 3'-phosphomonoesters, Hydrolytic Mechanism 2-iminobutanoate Deaminase Activity Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Cyclin D3-CDK6 Complex Regulation Of Fibroblast Proliferation Cyclin D1-CDK6 Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle FBXO Family Protein Binding PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration DNA Damage Checkpoint Signaling L-threonine Catabolic Process Cellular Response To Stress Positive Regulation Of Macromolecule Metabolic Process Linear Polyubiquitin Binding Threonine Metabolic Process Mitotic Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Cell Cycle Phase Transition Regulation Of Cell Cycle Process Cellular Response To Cell-matrix Adhesion Positive Regulation Of Metabolic Process Gliogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Monocyte Differentiation Cell Dedifferentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Oncogene-induced Cell Senescence Stress-induced Premature Senescence Negative Regulation Of Mitotic Cell Cycle IkappaB Kinase Complex Manchette Assembly Negative Regulation Of Cell Cycle Phase Transition Nucleus Deaminase Activity	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Lysosome Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling 4-hydroxyphenylpyruvate Dioxygenase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Cysteine-type Deubiquitinase Activity Protein Deubiquitination Protein Modification By Small Protein Removal Cysteine-type Peptidase Activity Deubiquitinase Activity Regulation Protein Catabolic Process At Presynapse Cysteine-type Endopeptidase Activity GDP-L-fucose Biosynthetic Process Fucose-1-phosphate Guanylyltransferase Activity Negative Regulation Of Antifungal Innate Immune Response Protein K27-linked Deubiquitination Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Fructose Catabolic Process Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate Glycerate Kinase Activity Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway L-tyrosine Catabolic Process
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