CA3 and GRM3

		CA3	GRM3
Description		carbonic anhydrase 3	glutamate metabotropic receptor 3
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Sarcomere	Plasma Membrane Postsynaptic Density Membrane Axon Presynaptic Membrane Neuron Projection Dendritic Spine Postsynaptic Membrane Astrocyte Projection Glutamatergic Synapse
	Molecular Function	Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding Nickel Cation Binding Phosphatase Activity Lyase Activity Metal Ion Binding	Group II Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Channel Regulator Activity Protein Binding Glutamate Receptor Activity Scaffold Protein Binding
	Biological Process	Skeletal Muscle Contraction Response To Oxidative Stress Positive Regulation Of Cell Population Proliferation Response To Bacterium Cellular Response To Insulin Stimulus Response To Lipid Negative Regulation Of Apoptotic Process Cellular Response To Leptin Stimulus Response To Ethanol Cellular Response To Hypoxia Response To Alcohol Liver Regeneration Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Gene Expression Cellular Response To Stress Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Postsynaptic Modulation Of Chemical Synaptic Transmission
Pathways		Reversible hydration of carbon dioxide	G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		Topiramate Ethoxzolamide Sulpiride Celecoxib Benzthiazide Valdecoxib Cyclothiazide Methazolamide Acetazolamide Dorzolamide Zonisamide Diclofenamide Brinzolamide Ellagic acid Saccharin	LY2140023
Diseases
GWAS		Blood protein levels ( 30072576) Blood trace element (Zn levels) ( 23720494) Estimated glomerular filtration rate ( 31152163) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin concentration ( 27863252)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 27611488) Autism spectrum disorder or schizophrenia ( 28540026) Brachial circumference ( 22479309) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Feeling worry ( 29500382) Hand grip strength (Mahalanobis distance) ( 32235003) LDL cholesterol levels in HIV infection ( 33109212) Neurociticism ( 29500382) Neuroticism ( 29255261) Refractive error ( 32231278) Schizophrenia ( 29483656 30285260 28991256 25056061) Seborrheic dermatitis ( 29203360) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		3 interacting genes: HPCAL1 LXN SRC	6 interacting genes: CALM1 GRIP1 PICK1 PPM1A SDCBP TAMALIN
Entrez ID		761	2913
HPRD ID		00260	03070
Ensembl ID		ENSG00000164879	ENSG00000198822
Uniprot IDs		P07451	A4D1D0 Q14832
PDB IDs		1Z93 1Z97 2HFW 3UYN 3UYQ	3SM9 4XAR 5CNK 5CNM 6B7H 7WI6 7WI8 7WIH 8JCU 8JCV 8JCW 8JCX 8JCY 8JCZ 8JD0 8JD1 8JD2 8JD3 9II2 9II3
Enriched GO Terms of Interacting Partners?		Regulation Of Catalytic Activity G Protein-coupled Glutamate Receptor Signaling Pathway Scaffold Protein Binding Group II Metabotropic Glutamate Receptor Activity Astrocyte Projection Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Activity Bone Resorption Angiotensin-activated Signaling Pathway Negative Regulation Of Hippo Signaling Negative Regulation Of Neutrophil Activation Regulation Of Toll-like Receptor 3 Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of Caveolin-mediated Endocytosis Connexin Binding Regulation Of Lamellipodium Morphogenesis Regulation Of Integrin Activation Positive Regulation Of Dephosphorylation Cellular Response To Progesterone Stimulus Positive Regulation Of Protein Maturation Intestinal Epithelial Cell Development Positive Regulation Of Podosome Assembly Regulation Of Podosome Assembly Signal Complex Assembly Positive Regulation Of Protein Processing Positive Regulation Of Integrin Activation Osteoclast Development Phospholipase Activator Activity Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Mitochondrial Depolarization Uterus Development Negative Regulation Of Focal Adhesion Assembly Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Neutrophil Activation Response To Platelet-derived Growth Factor Endolysosomal Toll-like Receptor Signaling Pathway Contractile Actin Filament Bundle Assembly Regulation Of Dephosphorylation Stress Fiber Assembly Progesterone Receptor Signaling Pathway Protein Tyrosine Kinase Activator Activity Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Phospholipase Binding Negative Regulation Of Mitochondrial Depolarization Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Columnar/cuboidal Epithelial Cell Development Negative Regulation Of Anoikis	Regulation Of Receptor-mediated Endocytosis Regulation Of Receptor Internalization Regulation Of Endocytosis Regulation Of Transport Monoamine Transport
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