ATP7B and ATOX1

Number of citations: 38 (PubMedID 10557326)
Data Source: HPRD (in vitro, in vivo, two hybrid)

		ATP7B	ATOX1
Name		ATPase copper transporting beta	antioxidant 1 copper chaperone
Structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Mitochondrion Endosome Late Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Basolateral Plasma Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm	Cytosol
	Molecular Function	Nucleotide Binding Copper Ion Transmembrane Transporter Activity Copper Ion Binding Protein Binding ATP Binding ATP Hydrolysis Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity P-type Divalent Copper Transporter Activity Metal Ion Binding P-type Monovalent Copper Transporter Activity	Copper Ion Binding Protein Binding Metallochaperone Activity Copper Chaperone Activity Copper-dependent Protein Binding Metal Ion Binding ATPase Binding Cuprous Ion Binding
	Biological Process	Monoatomic Ion Transport Monoatomic Cation Transport Copper Ion Transport Intracellular Copper Ion Homeostasis Intracellular Zinc Ion Homeostasis Lactation Copper Ion Import Monoatomic Ion Transmembrane Transport Response To Copper Ion Sequestering Of Calcium Ion Protein Maturation Establishment Of Localization In Cell Copper Ion Export Viral Translational Frameshifting Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane	Monoatomic Ion Transport Copper Ion Transport Intracellular Copper Ion Homeostasis Response To Oxidative Stress Negative Regulation Of Apoptotic Process Copper Ion Export
Pathways		Ion transport by P-type ATPases	Detoxification of Reactive Oxygen Species Ion influx/efflux at host-pathogen interface
Drugs		None	Cisplatin Sucrose Benzamidine
Diseases		Wilson disease; Hepatolenticular degeneration	None
GWAS		Clostridium difficile infection in multiple myeloma ( 29594489 ) Mean spheric corpuscular volume ( 32888494 ) Waist circumference adjusted for body mass index ( 28552196 )	Creatinine levels ( 29403010 ) Glomerular filtration rate ( 29403010 ) Red cell distribution width ( 32888494 ) Systolic blood pressure change trajectory ( 27980656 )
Interacting Genes		4 interacting genes: ATOX1 DCTN4 HP ZBTB16	9 interacting genes: ATP7A ATP7B CFAP410 COMP FAM118A FKBP4 GGPS1 NECAB1 TRAF4
Entrez ID		540	475
HPRD ID		06050	03779
Ensembl ID		ENSG00000123191	ENSG00000177556
Uniprot IDs		A0A669KB88 A0AAQ5BGL6 A0AAQ5BGP2 B7ZLR3 B7ZLR4 E7ET55 F5H562 F5H748 P35670	O00244
PDB IDs		2ARF 2EW9 2KOY 2LQB 2N7Y 2ROP 6A71 6A72 7XUK 7XUM 7XUN 7XUO 8IOY	1FE0 1FE4 1FEE 1TL4 1TL5 2K1R 2LQ9 3CJK 3IWL 3IWX 4QOT 4YDX 4YEA 5F0W 5T7L 7DC1 7ZC3
GO Terms Enriched among Interactors		Copper-dependent Protein Binding Copper Ion Export Copper Chaperone Activity Metallochaperone Activity Negative Regulation Of Hydrogen Peroxide Catabolic Process Germ-line Stem Cell Division Positive Regulation Of NK T Cell Differentiation Type 2 Angiotensin Receptor Binding Male Germ-line Stem Cell Asymmetric Division Hemoglobin Binding Negative Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of NK T Cell Differentiation Copper Ion Transmembrane Transport Dynactin Complex Cuprous Ion Binding Ossification Involved In Bone Maturation Response To Oxidative Stress Haptoglobin-hemoglobin Complex Mesonephros Development Asymmetric Cell Division Copper Ion Transport Intracellular Copper Ion Homeostasis Regulation Of Hydrogen Peroxide Metabolic Process Endocytic Vesicle Lumen Copper Ion Homeostasis Positive Regulation Of Chondrocyte Differentiation Cytoplasmic Dynein Complex Stem Cell Division Antioxidant Activity	Copper Ion Transport P-type Divalent Copper Transporter Activity P-type Monovalent Copper Transporter Activity Copper-dependent Protein Binding Copper Ion Export Copper Ion Import Copper Ion Transmembrane Transporter Activity Copper Ion Transmembrane Transport ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Perinuclear Region Of Cytoplasm Intracellular Copper Ion Homeostasis Copper Ion Homeostasis Copper Ion Binding Skin Development Collagen Fibril Organization Steroid Hormone Receptor Complex Assembly Geranylgeranyl Diphosphate Biosynthetic Process Prenyl Diphosphate Synthase Activity Geranylgeranyl Diphosphate Synthase Activity Geranyl Diphosphate Biosynthetic Process (2E,6E)-farnesyl Diphosphate Synthase Activity Dimethylallyltranstransferase Activity Cartilage Development Trans-Golgi Network Membrane Superoxide Dismutase Copper Chaperone Activity Geranyl Diphosphate Metabolic Process P-type Ion Transporter Activity Epinephrine Metabolic Process Tendon Development Cartilage Homeostasis Male Sex Differentiation Farnesyl Diphosphate Biosynthetic Process Negative Regulation Of Catecholamine Metabolic Process Sequestering Of Calcium Ion Late Endosome Metal Ion Transport Farnesyl Diphosphate Metabolic Process Pyramidal Neuron Development Viral Translational Frameshifting