HOXD8 and LDLRAP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HOXD8	LDLRAP1
Description		homeobox D8	low density lipoprotein receptor adaptor protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Cytoplasm Early Endosome Cytosol Neurofilament Plasma Membrane Cytoplasmic Side Of Plasma Membrane Basal Plasma Membrane Axon Clathrin-coated Endocytic Vesicle Membrane Recycling Endosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Amyloid-beta Binding Phosphotyrosine Residue Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Signaling Receptor Complex Adaptor Activity Clathrin Binding Signaling Adaptor Activity AP-2 Adaptor Complex Binding Clathrin Adaptor Activity AP-1 Adaptor Complex Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Axis Specification, Embryo Anterior/posterior Pattern Specification Positive Regulation Of Transcription By RNA Polymerase II Skeletal System Morphogenesis	Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Steroid Metabolic Process Cholesterol Metabolic Process Cholesterol Transport Receptor Internalization Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Amyloid Precursor Protein Metabolic Process Regulation Of Protein Binding Positive Regulation Of Receptor-mediated Endocytosis Cellular Response To Cytokine Stimulus Receptor-mediated Endocytosis Involved In Cholesterol Transport Positive Regulation Of Cholesterol Metabolic Process Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport
Pathways			Vitamin D (calciferol) metabolism Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Chylomicron clearance LDL clearance Transport of RCbl within the body
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Chronic kidney disease ( 31152163) Estimated glomerular filtration rate ( 30604766 31015462 31152163) Glomerular filtration rate (creatinine) ( 28452372) Male-pattern baldness ( 28196072) Urate levels ( 31578528)	Cholesterol, total ( 20686565 24097068 25961943) LDL cholesterol ( 20686565 24097068 25961943) LDL cholesterol levels ( 28334899) Mean platelet volume ( 27863252 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Total cholesterol levels ( 28334899)
Interacting Genes		8 interacting genes: ANXA7 BAIAP2 CDKN1A HMGB1 LDLRAP1 NCK2 PFDN1 RCC1	18 interacting genes: AP1B1 AP2B1 APP C6orf58 CLTC ESPNL FHL2 HOXC8 HOXD8 LDLR LRP2 MAGEA4 MAPK8IP3 NOTO PAX5 PSD4 SNCA TFAP2A
Entrez ID		3234	26119
HPRD ID		00868	05765
Ensembl ID		ENSG00000175879	ENSG00000157978
Uniprot IDs		A0A0A0MSX5 P13378	B3KR97 Q5SW96
PDB IDs			2G30
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Cytoskeletal Anchor Activity Positive Regulation Of Leukocyte Proliferation Signaling Receptor Complex Adaptor Activity Vesicle Membrane Cytoplasm Regulation Of Leukocyte Proliferation Regulation Of Mononuclear Cell Proliferation Phosphotyrosine Residue Binding Positive Regulation Of Actin Filament Polymerization Phosphatidylserine Binding Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell Population Proliferation PCNA-p21 Complex Cell Cycle G1/S Phase Transition Negative Regulation Of Cardiac Muscle Tissue Regeneration G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Activation Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Myeloid Progenitor Cell Differentiation Negative Regulation Of Apoptotic Cell Clearance Regulation Of Supramolecular Fiber Organization Amyloid-beta Binding Positive Regulation Of Protein Polymerization Signaling Adaptor Activity Scaffold Protein Binding Dendritic Spine Cytoplasm Neuron Projection Branch Point Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Receptor-mediated Endocytosis Involved In Cholesterol Transport Regulation Of Protein-containing Complex Assembly Positive Regulation Of T Cell Proliferation C-X-C Chemokine Binding Alphav-beta3 Integrin-HMGB1 Complex T-helper 1 Cell Activation Positive Regulation Of Mismatch Repair Positive Regulation Of Intracellular Cholesterol Transport Regulation Of Lymphocyte Activation Cellular Response To Cell-matrix Adhesion Regulation Of Mismatch Repair Plasmacytoid Dendritic Cell Activation Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Glycogen Catabolic Process Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress	Clathrin-coated Pit Endolysosome Membrane Clathrin-coated Endocytic Vesicle Membrane Receptor-mediated Endocytosis Negative Regulation Of Transcription By RNA Polymerase II Amyloid-beta Clearance Endocytosis Skeletal System Morphogenesis Vesicle-mediated Transport Positive Regulation Of Lysosomal Protein Catabolic Process Artery Development Clathrin Coat Kidney Development Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Positive Regulation Of Protein Catabolic Process In The Vacuole Import Into Cell Negative Regulation Of RNA Metabolic Process Pattern Specification Process Receptor Internalization Anatomical Structure Morphogenesis Regulation Of Lysosomal Protein Catabolic Process Clathrin Adaptor Complex Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Lysosome Low-density Lipoprotein Particle Low-density Lipoprotein Particle Receptor Activity Negative Regulation Of Metabolic Process Regulation Of Amyloid Fibril Formation Regionalization Transcytosis Negative Regulation Of Apoptotic Process Trans-Golgi Network Membrane Clathrin Coat Assembly Regulation Of Neurotransmitter Uptake Negative Regulation Of Programmed Cell Death Developmental Process Endosome Lumen Clathrin-coated Endocytic Vesicle Cellular Response To Copper Ion Regulation Of Receptor Recycling Coronary Vasculature Development Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Low-density Lipoprotein Particle Receptor Binding Regulation Of Presynapse Assembly Synaptic Vesicle
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?