HOXD8 and RCC1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		HOXD8	RCC1
Gene Name		homeobox D8	regulator of chromosome condensation 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nuclear Chromatin Condensed Nuclear Chromosome Nucleus Nucleoplasm Cytoplasm Nuclear Membrane
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription	Chromatin Binding Ran Guanyl-nucleotide Exchange Factor Activity Protein Binding Nucleosomal DNA Binding Histone Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Anterior/posterior Axis Specification, Embryo Positive Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Morphogenesis	G1/S Transition Of Mitotic Cell Cycle Mitotic Spindle Organization Chromosome Segregation Mitotic Nuclear Division Regulation Of Mitotic Nuclear Division Viral Process Positive Regulation Of Ran GTPase Activity Spindle Assembly Cell Division
Pathways			HIV Life Cycle Rev-mediated nuclear export of HIV RNA HIV Infection Nuclear import of Rev protein Rev-mediated nuclear export of HIV RNA Host Interactions of HIV factors Interactions of Rev with host cellular proteins Late Phase of HIV Life Cycle
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: ANXA7 CDKN1A HMGB1 PFDN1 RCC1	50 interactors: ACTB APLP1 BAG6 CCT7 CDK1 CDK2AP2 CHGB CHKA CSAD CSNK1A1 DDAH2 DYNC1I1 FAF1 FLAD1 GNB2 HADHB HIST1H3A HIST1H4A HIST2H2AA3 HIST2H2AC HIST2H2BE HMGA1 HOXD8 KMT2B KPNA3 KPNA4 KPNB1 LRIF1 NGFR NTMT1 NUDT21 NUP98 PDHB PKM PTMA RAN RANBP1 RANBP3 RPA1 SDF4 SPRED1 TLE1 TP53 TRMT2A TUBB3 UNC119 USP4 WIZ XPO1 ZNF135
Entrez ID		3234	1104
HPRD ID		00868	01559
Ensembl ID		ENSG00000175879	ENSG00000180198
Uniprot IDs		F8VSA3 P13378	P18754 Q5T081
PDB IDs			1A12 1I2M
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Apoptotic Cell Clearance Regulation Of Cellular Component Organization Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Base-excision Repair, DNA Ligation Intestinal Epithelial Cell Maturation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Response To UV-B Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Negative Regulation Of Gene Expression Cell Cycle Positive Regulation Of Ran GTPase Activity DNA Ligation Involved In DNA Repair Stress-induced Premature Senescence Regulation Of Apoptotic Cell Clearance Negative Regulation Of Phagocytosis Positive Regulation Of Catalytic Activity Cellular Water Homeostasis Regulation Of Mitotic Cell Cycle DNA Ligation Dendritic Cell Chemotaxis Regulation Of Metabolic Process Mitotic Cell Cycle Arrest Response To UV-B Intestinal Epithelial Cell Development Regulation Of Protein Import Into Nucleus, Translocation Apoptotic DNA Fragmentation Leukocyte Activation Regulation Of Cell Cycle Process Intestinal Epithelial Cell Differentiation Epithelial Cell Maturation Regulation Of DNA-templated Transcription, Initiation Epithelial Cell Differentiation Dendritic Cell Migration Response To Arsenic-containing Substance Myeloid Dendritic Cell Activation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Chemotaxis Positive Regulation Of Programmed Cell Death V(D)J Recombination Cellular Senescence Positive Regulation Of Cell Death Apoptotic Nuclear Changes Cell Volume Homeostasis Immune System Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To X-ray	Protein Localization To Nucleus Protein Import Into Nucleus Nuclear Import Intracellular Transport Of Virus Protein Localization To Organelle Protein Import Nucleocytoplasmic Transport Nuclear Transport Cell Cycle Mitotic Cell Cycle DNA Packaging Cellular Component Assembly Protein Complex Assembly Cell Cycle Process Chromatin Assembly Cellular Localization Cellular Protein Localization Chromatin Organization NLS-bearing Protein Import Into Nucleus Viral Process Protein Localization Ribosomal Small Subunit Export From Nucleus Chromatin Assembly Or Disassembly DNA Conformation Change Cellular Nitrogen Compound Metabolic Process Chromosome Organization Viral Life Cycle Mitotic Cell Cycle Process Cellular Metabolic Process Positive Regulation Of Cell Aging Establishment Of Protein Localization To Organelle Organelle Organization Establishment Of Protein Localization Ribosomal Large Subunit Export From Nucleus Nitrogen Compound Metabolic Process Intracellular Transport Ribosomal Subunit Export From Nucleus DNA Replication-dependent Nucleosome Assembly Protein Targeting Nucleosome Organization DNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process 'de Novo' Posttranslational Protein Folding Cellular Macromolecular Complex Assembly 'de Novo' Protein Folding Base-excision Repair DNA Methylation On Cytosine Protein Transport Protein-DNA Complex Assembly
Tagcloud ?		chip deep dysregulated dysregulation h3k27me3 homeobox hoxb7 hoxc10 hoxc13 irx1 irx4 keratinocytes mark neoplastic okf6 oncomine polycomb prc prc2 repressive rnaseq scc six2 suz12 tert1r transcripts tshz3 tumorigenic	almost cellulose chromosome column condensation consistently cytoplasm digestion dispersed dnase eluted encode kd located locates maturation mitotic nacl nuclei onset p45 prepared presumably putative regulating regulator released sequential synthetic
Tagcloud (Difference) ?		chip deep dysregulated dysregulation h3k27me3 homeobox hoxb7 hoxc10 hoxc13 irx1 irx4 keratinocytes mark neoplastic okf6 oncomine polycomb prc prc2 repressive rnaseq scc six2 suz12 tert1r transcripts tshz3 tumorigenic	almost cellulose chromosome column condensation consistently cytoplasm digestion dispersed dnase eluted encode kd located locates maturation mitotic nacl nuclei onset p45 prepared presumably putative regulating regulator released sequential synthetic
Tagcloud (Intersection) ?