KRT36 and KRT8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRT36	KRT8
Description		keratin 36	keratin 8
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Intermediate Filament Keratin Filament Intermediate Filament Cytoskeleton Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Intermediate Filament Cell-cell Junction Apicolateral Plasma Membrane Nuclear Matrix Z Disc Sarcolemma Keratin Filament Intermediate Filament Cytoskeleton Extracellular Exosome Cell Periphery
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis	Protein Binding Scaffold Protein Binding
	Biological Process	Morphogenesis Of An Epithelium Epithelial Cell Differentiation Intermediate Filament Organization Regulation Of Keratinocyte Differentiation	Tumor Necrosis Factor-mediated Signaling Pathway Response To Other Organism Cell Differentiation Involved In Embryonic Placenta Development Extrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process
Pathways		Keratinization Formation of the cornified envelope	Keratinization Formation of the cornified envelope Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells
Drugs			Tenecteplase Lanoteplase Copper
Diseases
GWAS			Alanine aminotransferase levels ( 33339817 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Cancer (pleiotropy) ( 27197191) Gamma glutamyl transferase levels ( 29403010) Mean reticulocyte volume ( 32888494) Opioid dependence (time to event) ( 34124712) Prostate cancer ( 21743057) Sick sinus syndrome ( 33580673)
Interacting Genes		60 interacting genes: ABI2 ABI3 AIMP2 AMOT APP BCAS2 C1orf216 CCBE1 CCHCR1 CDC23 DMRT3 EXOC8 GEM GPS2 HCK HGS HOXC8 KRT1 KRT2 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT73 KRT74 KRT75 KRT76 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT82 KRT83 KRT85 KRT86 MAP3K1 MYOZ1 MYOZ3 PKN1 PLEKHN1 PPP1R18 PSMB1 QARS1 RESF1 RIBC1 SMURF1 TMSB4X TRAF4 TSGA10IP TTC23 TTLL10 TXLNA ZNF414 ZNF785	53 interacting genes: ANXA1 BYSL CEP57 CLK1 DEDD DMD EGFR ESR1 FBXO25 FGFR3 GRB2 HSPA5 IKBKG KIFC3 KPNA2 KRT13 KRT15 KRT16 KRT18 KRT24 KRT25 KRT26 KRT27 KRT28 KRT31 KRT32 KRT33B KRT35 KRT36 KRT37 KRT38 KRT40 LINC01554 MAPK1 MAPK14 MAPK3 MAPK8 NEK6 OGT PIWIL2 PKD1 PKP1 PLAT PNN PPL QRSL1 RAF1 SUMO2 TCHP TFIP11 TRIM54 TROAP WBP2
Entrez ID		8689	3856
HPRD ID		05174	01015
Ensembl ID		ENSG00000126337	ENSG00000170421
Uniprot IDs		O76013	P05787 Q7L4M3
PDB IDs			7K3C 7K3X 7K3Y
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Keratinization Intermediate Filament Organization Keratin Filament Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Supramolecular Fiber Organization Cytoskeleton Organization Organelle Organization Cytosol Protein Binding Extracellular Exosome Epidermis Development Intermediate Filament Cytoskeleton Cornified Envelope FATZ Binding Tissue Development Telethonin Binding Actin-based Cell Projection Structural Constituent Of Cytoskeleton Aminoacyl-tRNA Synthetase Multienzyme Complex SCAR Complex Developmental Process Regulation Of Anatomical Structure Morphogenesis Peptidyl-tyrosine Phosphorylation	Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Structural Constituent Of Skin Epidermis Keratin Filament Intermediate Filament Organization Intermediate Filament Structural Molecule Activity Morphogenesis Of An Epithelium Tissue Morphogenesis Epithelial Cell Differentiation Cytoskeleton Organization Cytoskeleton Supramolecular Fiber Organization Anatomical Structure Morphogenesis Cellular Developmental Process Cell Differentiation Organelle Organization Developmental Process Cytosol Extracellular Exosome MAP Kinase Activity Schwann Cell Development Stress-activated MAPK Cascade ERBB2 Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Desmosome ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Response To Mechanical Stimulus Insulin-like Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Hair Cycle Regulation Of Protein Metabolic Process Intracellular Signaling Cassette Tissue Development Structural Constituent Of Cytoskeleton Pseudopodium Protein Kinase Activity Interleukin-34-mediated Signaling Pathway Cornified Envelope Protein Binding Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cyclase Activity Face Development Epidermal Growth Factor Receptor Signaling Pathway Glial Cell Development Regulation Of Golgi Inheritance Response To Muscle Stretch
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