HOXA5 and PBX2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HOXA5	PBX2
Description		homeobox A5	PBX homeobox 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding DNA-binding Transcription Factor Binding
	Biological Process	Skeletal System Development Morphogenesis Of An Epithelium Respiratory System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Respiratory Gaseous Exchange By Respiratory System Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Cell Migration Negative Regulation Of Angiogenesis Lung Development Thyroid Gland Development Regulation Of Mammary Gland Epithelial Cell Proliferation Multicellular Organism Growth Positive Regulation Of Apoptotic Process Positive Regulation Of Myeloid Cell Differentiation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development Bronchiole Development Trachea Morphogenesis Epithelial Tube Branching Involved In Lung Morphogenesis Lung Goblet Cell Differentiation Lobar Bronchus Epithelium Development Lung-associated Mesenchyme Development Trachea Cartilage Morphogenesis Cartilage Morphogenesis Intestinal Epithelial Cell Maturation Mesenchymal-epithelial Cell Signaling Mammary Gland Epithelial Cell Differentiation Mammary Gland Alveolus Development Cell-cell Signaling Involved In Mammary Gland Development	Eye Development Regulation Of DNA-templated Transcription Brain Development Animal Organ Morphogenesis Proximal/distal Pattern Formation Embryonic Limb Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Neuron Development
Pathways
Drugs
Diseases
GWAS		Chronic venous disease ( 28374850)	Advanced age-related macular degeneration ( 26691988) Anxiety ( 33859377) Asthma ( 21804548 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Coronary artery disease ( 33020668) Crohn's disease ( 23266558) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Moderate to vigorous physical activity levels ( 29899525) Prostate cancer ( 23535732) Refractive error ( 32231278) Rheumatic heart disease ( 32488134) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172)
Interacting Genes		16 interacting genes: CDX4 CTBP2 DDIT3 DNMT3L DVL3 FOXA2 FOXO1 GTF2A1L MEIS1 PBX1 PBX2 PICK1 PRMT6 SMAD1 TWIST1 ZNF408	38 interacting genes: BAIAP2 BFSP2 BLOC1S1 BLOC1S5 BRMS1L CARD9 CCDC88B CDCA7L CENPBD1P COPS6 DCTN3 EFHC1 ELP1 FAM90A1 HOXA1 HOXA5 HOXA9 HOXB5 HOXB8 HOXC5 HOXC8 HOXC9 MCRS1 MSC MTREX NUP62 PBX1 PKNOX1 PPFIBP1 RIPPLY2 RPL4 RPS6KC1 SMYD3 TTC3 UBE2E1 ZCWPW2 ZDHHC7 ZNF587
Entrez ID		3202	5089
HPRD ID		00840	08890
Ensembl ID		ENSG00000106004	ENSG00000204304
Uniprot IDs		P20719	A0A024RCR3 P40425
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression DNA-binding Transcription Factor Activity Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process DNA Binding Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Pattern Specification Process Negative Regulation Of Cell Differentiation Regulation Of Metabolic Process Transcription Regulator Complex Cellular Developmental Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription Coregulator Binding Negative Regulation Of Developmental Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Embryonic Pattern Specification Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Differentiation Nucleus Sequence-specific DNA Binding Embryonic Limb Morphogenesis Regulation Of Developmental Process Limb Morphogenesis Stem Cell Differentiation Animal Organ Development Eye Development Developmental Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Proximal/distal Pattern Formation	Anterior/posterior Pattern Specification Embryonic Skeletal System Development Regionalization DNA-binding Transcription Factor Activity Pattern Specification Process Skeletal System Morphogenesis Sequence-specific Double-stranded DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Embryonic Skeletal System Morphogenesis Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Embryonic Morphogenesis Skeletal System Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Embryonic Organ Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Animal Organ Morphogenesis Proximal/distal Pattern Formation Nucleoplasm Regulation Of Gene Expression Anatomical Structure Morphogenesis Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II BLOC-1 Complex Anterograde Synaptic Vesicle Transport DNA Binding Hemopoiesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Myeloid Cell Differentiation
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