HOXA5 and FOXA2

Number of citations: 0 (PubMedID 12163409)
Data Source: BioGRID (pull down), HPRD (in vitro)

		HOXA5	FOXA2
Name		homeobox A5	forkhead box A2
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus Nucleoplasm Cytoplasm Cell Junction
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Skeletal System Development Morphogenesis Of An Epithelium Respiratory System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Respiratory Gaseous Exchange By Respiratory System Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Cell Migration Negative Regulation Of Angiogenesis Lung Development Thyroid Gland Development Regulation Of Mammary Gland Epithelial Cell Proliferation Multicellular Organism Growth Positive Regulation Of Apoptotic Process Positive Regulation Of Myeloid Cell Differentiation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development Bronchiole Development Trachea Morphogenesis Epithelial Tube Branching Involved In Lung Morphogenesis Lung Goblet Cell Differentiation Lobar Bronchus Epithelium Development Lung-associated Mesenchyme Development Trachea Cartilage Morphogenesis Cartilage Morphogenesis Intestinal Epithelial Cell Maturation Mesenchymal-epithelial Cell Signaling Mammary Gland Epithelial Cell Differentiation Mammary Gland Alveolus Development Cell-cell Signaling Involved In Mammary Gland Development	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Adult Locomotory Behavior Anatomical Structure Morphogenesis Negative Regulation Of Epithelial To Mesenchymal Transition Cell Differentiation Regulation Of Blood Coagulation Endocrine Pancreas Development Positive Regulation Of Embryonic Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Interleukin-6 Dopaminergic Neuron Differentiation Primitive Streak Formation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Gastrulation
Pathways		None	Regulation of gene expression in beta cells Positive Regulation of CDH1 Gene Transcription Formation of axial mesoderm Formation of definitive endoderm Developmental Lineage of Pancreatic Acinar Cells Developmental Lineage of Pancreatic Ductal Cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells
GWAS		Chronic venous disease ( 28374850 )	Adolescent idiopathic scoliosis ( 25784220 ) Apolipoprotein A1 levels ( 32203549 ) Birth weight ( 31043758 ) Body size at age 10 ( 32376654 ) Fasting blood glucose ( 22581228 33842983 ) Fasting blood glucose (BMI interaction) ( 22581228 ) Fasting glucose ( 34059833 ) Fasting plasma glucose ( 20152958 25187374 ) Gout ( 22179738 ) Hypothyroidism ( 27182965 ) Male-pattern baldness ( 27182965 22693459 ) Monobrow ( 27182965 ) Type 2 diabetes ( 30054458 32499647 ) Vitamin D levels ( 26704534 )
Interacting Genes		16 interacting genes: CDX4 CTBP2 DDIT3 DNMT3L DVL3 FOXA2 FOXO1 GTF2A1L MEIS1 PBX1 PBX2 PICK1 PRMT6 SMAD1 TWIST1 ZNF408	10 interacting genes: EN2 GSC HOXA5 LHX1 MIP NCOA1 ONECUT1 OTUD3 OTX2 TLE1
Entrez ID		3202	3170
HPRD ID		00840	02618
Ensembl ID		ENSG00000106004	ENSG00000125798
Uniprot IDs		P20719	B0ZTD4 Q9Y261
PDB IDs		Not available	5X07 7YZE 7YZF
GO Terms Enriched among Interactors		DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression DNA-binding Transcription Factor Activity Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process DNA Binding Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Pattern Specification Process Negative Regulation Of Cell Differentiation Regulation Of Metabolic Process Transcription Regulator Complex Cellular Developmental Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription Coregulator Binding Negative Regulation Of Developmental Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Embryonic Pattern Specification Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Differentiation Nucleus Sequence-specific DNA Binding Embryonic Limb Morphogenesis Regulation Of Developmental Process Limb Morphogenesis Stem Cell Differentiation Animal Organ Development Eye Development Developmental Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Proximal/distal Pattern Formation	Sequence-specific Double-stranded DNA Binding Chromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gastrulation Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Primitive Streak Formation Regulation Of Gastrulation Neuron Differentiation DNA Binding Animal Organ Development Positive Regulation Of Embryonic Development Regulation Of Gene Expression Anatomical Structure Morphogenesis Embryonic Morphogenesis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Developmental Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Midbrain Development Dopaminergic Neuron Differentiation Endoderm Development Animal Organ Morphogenesis Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Gastrulation Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Cerebellum Development Regionalization Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Tissue Development Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Dorsal Spinal Cord Interneuron Posterior Axon Guidance Nephric Duct Elongation Ectoderm Formation Metanephric Renal Vesicle Morphogenesis Renal Vesicle Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose