HNRNPH1 and FLT4

		HNRNPH1	FLT4
Description		heterogeneous nuclear ribonucleoprotein H1	fms related receptor tyrosine kinase 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Membrane Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Extracellular Region Nucleus Cytoplasm Plasma Membrane Membrane Receptor Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Poly(U) RNA Binding Identical Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Growth Factor Binding Protein Phosphatase Binding Protein Homodimerization Activity
	Biological Process	MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing RNA Splicing Regulation Of RNA Splicing	Angiogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Vasculature Development Lymph Vessel Development Lymphangiogenesis Sprouting Angiogenesis Respiratory System Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Respiratory Gaseous Exchange By Respiratory System Positive Regulation Of Cell Population Proliferation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Endothelial Cell Migration Cell Migration Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Lung Alveolus Development Blood Vessel Morphogenesis Regulation Of Blood Vessel Remodeling Positive Regulation Of ERK1 And ERK2 Cascade
Pathways		FGFR2 alternative splicing mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA	VEGF binds to VEGFR leading to receptor dimerization NOTCH4 Intracellular Domain Regulates Transcription High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Copper	Sorafenib Sunitinib Vatalanib TG-100801 Denibulin Linifanib IMC-1C11 Pazopanib Axitinib Regorafenib Lenvatinib Nintedanib Tivozanib Fostamatinib Selpercatinib
Diseases			Lymphedemas, including: Lymphedema, hereditary I; Lymphedema-distichiasis syndrome (LD); Hypotrichosis-lymphedema-telangiectasia syndrome (HLTS)
GWAS		Daytime sleep phenotypes ( 27126917) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)	Blood protein levels ( 30072576) Platelet distribution width ( 32888494) Serum folate levels ( 29953918)
Interacting Genes		136 interacting genes: APBB1 ARHGEF16 CASP7 CATSPER1 CCDC120 CCNK CRMP1 DDX17 DUX4 DZIP3 ENKD1 ERG FOXP1 GPANK1 GPS2 HIPK3 HNRNPF HNRNPH3 HNRNPM KHSRP KRTAP13-2 LMO1 LMO3 LNX1 MAGED1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MRPL53 MSI2 MTNR1A MYPOP NCBP1 NCBP2 NDRG1 NFKBID NUDT16L1 OGT OXER1 PATZ1 PCAT1 PEX5 PIN1 POLR1C RALY RAMAC RBFOX2 RBM38 RNF10 RNF4 SAXO4 SF1 SF3B4 SNRPB SNRPC SPG21 SREK1 SUMO2 SUMO4 TCERG1 TEKT3 TEKT4 TOM1L1 WEE2-AS1 YPEL3 YWHAG YWHAQ	16 interacting genes: ATF7IP DUSP19 ERBB2 GRB2 IKBKG ITGA5 ITGB1 KDR LRRK1 NEDD4 PTK2 PTPN11 SHC1 SHC3 VEGFC VEGFD
Entrez ID		3187	2324
HPRD ID		03021	00636
Ensembl ID		ENSG00000169045	ENSG00000037280
Uniprot IDs		A0A384MEJ3 A0A9L9PY23 A0AAG2UWX3 E9PCY7 G8JLB6 H0YBD7 P31943	E9PD35 P35916
PDB IDs		2LXU 6DHS 7ZUG	4BSJ 4BSK
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Translation MRNA Destabilization RNA Destabilization Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Metabolic Process Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Cell Migration Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Locomotion Regulation Of Translation Regulation Of Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of MRNA Stability Negative Regulation Of Cytokine Production Regulation Of RNA Stability Regulation Of Angiogenesis Regulation Of MRNA Metabolic Process Regulation Of Vasculature Development Regulation Of Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Multicellular Organismal Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Developmental Process Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cell Motility	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Signal Transduction Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Phosphotyrosine Residue Binding Receptor Tyrosine Kinase Binding Regulation Of Angiogenesis Intracellular Signal Transduction Vascular Endothelial Growth Factor Receptor 3 Binding Vascular Endothelial Growth Factor Signaling Pathway Receptor Internalization Integrin Alpha5-beta1 Complex Negative Regulation Of Anoikis Regulation Of Vasculature Development Negative Regulation Of Apoptotic Process Regulation Of Anatomical Structure Morphogenesis Regulation Of Intracellular Signal Transduction Positive Regulation Of Locomotion Positive Regulation Of Positive Chemotaxis Regulation Of Anoikis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Population Proliferation Integrin-mediated Signaling Pathway Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Binding Cellular Response To Growth Factor Stimulus Positive Regulation Of Mast Cell Chemotaxis Neurotrophin TRKA Receptor Binding Beta-2 Adrenergic Receptor Binding Positive Regulation Of Chemotaxis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Integrin Binding Response To Growth Factor Peptidyl-tyrosine Phosphorylation Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Cell Migration Developmental Process
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