RBFOX2 and CLASP2

Number of citations of the paper that reports this interaction (PubMedID 30217970)
38

Data Source:
BioGRID (two hybrid)

		RBFOX2	CLASP2
Description		RNA binding fox-1 homolog 2	cytoplasmic linker associated protein 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Chromosome, Centromeric Region Kinetochore Chromosome Cytoplasm Golgi Apparatus Trans-Golgi Network Centrosome Microtubule Organizing Center Spindle Kinetochore Microtubule Cytosol Cytoskeleton Microtubule Spindle Microtubule Cytoplasmic Microtubule Plasma Membrane Focal Adhesion Cell Cortex Membrane Cortical Microtubule Cytoskeleton Cell Leading Edge Ruffle Membrane Cell Projection Axonal Growth Cone Basal Cortex Mitotic Spindle Glutamatergic Synapse Cortical Microtubule Plus-end
	Molecular Function	Nucleic Acid Binding Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding DNA-binding Transcription Factor Binding	Dystroglycan Binding Protein Binding Microtubule Binding Microtubule Plus-end Binding Actin Filament Binding Protein Tyrosine Kinase Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Nervous System Development RNA Splicing RNA Metabolic Process Estrogen Receptor Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of RNA Splicing Negative Regulation Of DNA-templated Transcription	Microtubule Cytoskeleton Organization Vesicle Targeting Microtubule Nucleation Negative Regulation Of Microtubule Depolymerization Golgi Organization Mitotic Spindle Organization Establishment Or Maintenance Of Cell Polarity Exit From Mitosis Regulation Of Gastrulation Positive Regulation Of Epithelial Cell Migration Regulation Of Epithelial To Mesenchymal Transition Regulation Of Axon Extension Microtubule Organizing Center Organization Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule Polymerization Regulation Of Microtubule-based Process Regulation Of Actin Cytoskeleton Organization Microtubule Anchoring Platelet-derived Growth Factor Receptor-beta Signaling Pathway Establishment Of Mitotic Spindle Localization Positive Regulation Of Exocytosis Cell Division Negative Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Negative Regulation Of Focal Adhesion Assembly Basement Membrane Organization Positive Regulation Of Extracellular Matrix Disassembly Mitotic Spindle Assembly Presynaptic Cytoskeleton Organization Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Basement Membrane Assembly Involved In Embryonic Body Morphogenesis
Pathways		FGFR2 alternative splicing	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Role of ABL in ROBO-SLIT signaling RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Reading disability or specific language impairment (pleiotropy) ( 25065397) Red cell distribution width ( 32888494) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Femur bone mineral density x serum urate levels interaction ( 34046847) Metabolite levels ( 23823483)
Interacting Genes		182 interacting genes: ADARB1 ALG13 ANKHD1 APH1A ATN1 ATXN1 ATXN1L BAG4 BOLL C1orf94 CALD1 CAMK2A CAMK2B CHAF1A CHERP CLASP2 CPSF7 DAB1 DAZAP2 DDX21 DDX5 DEDD2 DENND1B DMRTB1 EIF4ENIF1 ELAVL1 ELAVL2 ESR1 ESR2 FAM168B FBXO7 FSAF1 GIMAP4 GLIS2 GTF2A1L H1-4 HMGA1 HNRNPAB HNRNPF HNRNPH1 HNRNPH2 HNRNPK KHDRBS1 KHDRBS2 KIF20A KRT31 KRTAP6-2 LMNA LSM5 MAGED1 MAPK1IP1L MBNL1 MED7 MIR1-1 MIR106A MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-2 MIR140 MIR141 MIR143 MIR155 MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR9-1 MIR9-2 MIR9-3 MIR93 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MRPL4 MSI2 MTG1 MYO1C NAF1 NLGN3 NOL8 NR2E3 NXF1 OGT OXER1 PA2G4 PCBP1 PCBP2 PCNP PDIA3 PEG10 POLR3D PPIL4 PRMT5 PRPF19 PRPF38B PRRC2B PSMA3 PSMF1 PTBP1 PURB QARS1 QKI RBFOX1 RBFOX3 RBM12 RBM17 RBM22 RBM23 RBM42 RBPMS RBPMS2 RERE RHOXF2 RNF8 RPL3 RPL4 RPN1 RPS13 RPS28 SDHC SF1 SF3A1 SF3B3 SF3B4 SMN1 SNRPA SNRPC SNW1 SPATS2L SPMIP9 SPOP SRP68 ST13 SUPV3L1 SURF6 TNRC6A TOLLIP U2AF2 UBQLN2 VAC14 YTHDF1 YTHDF3 ZC3H10 ZNF137P	15 interacting genes: ADRB2 AKT1 CCR4 CLIP1 CLIP2 CREBBP CSNK2A1 ERBB2 FEZ1 FEZ2 MAPRE1 MAPRE2 PYGM RBFOX2 SRPK2
Entrez ID		23543	23122
HPRD ID		15231	12054
Ensembl ID		ENSG00000100320	ENSG00000163539
Uniprot IDs		A0A8Q3WKT3 O43251	A0A0U1RQI6 A0A804HJG7 E7ERI8 E7EW49 J3KR49 O75122
PDB IDs		2CQ3	3WOY 5NR4 8WHH 8WHI 8WHJ 8WHK 8WHL
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity RISC Complex Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of MRNA Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Metabolic Process RNA Binding Extracellular Vesicle Positive Regulation Of MRNA Catabolic Process Regulation Of Metabolic Process MRNA Destabilization RNA Destabilization Negative Regulation Of Translation Nucleic Acid Binding Regulation Of Translation Regulation Of RNA Stability Regulation Of MRNA Stability Regulation Of RNA Splicing MRNA Binding Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Primary Metabolic Process Negative Regulation Of Cytokine Production Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway MRNA Processing Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process RNA Processing Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Angiogenesis Regulation Of Vasculature Development	Microtubule Plus-end Binding Microtubule Plus-end Microtubule Cytoskeleton Regulation Of Macroautophagy Regulation Of Microtubule-based Process Negative Regulation Of Macroautophagy Microtubule Regulation Of Autophagy Regulation Of Organelle Organization Negative Regulation Of Autophagosome Assembly Regulation Of Cellular Component Organization Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Microtubule Binding Protein Localization To Microtubule Nervous System Development Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Autophagy Protein Localization To Organelle Execution Phase Of Apoptosis Positive Regulation Of Cellular Component Organization Spindle Midzone Negative Regulation Of Catabolic Process Identical Protein Binding Positive Regulation Of Cell Growth 14-3-3 Protein Binding Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Microtubule Polymerization Intracellular Signal Transduction Cell Cortex Microtubule Cytoskeleton Organization Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Organelle Organization Positive Regulation Of Mini Excitatory Postsynaptic Potential Organelle Organization Peptidyl-serine Phosphorylation Cellular Response To Epidermal Growth Factor Stimulus Intracellular Signaling Cassette Negative Regulation Of Translational Initiation Protein Kinase Activity Regulation Of TRNA Methylation Regulation Of Transcription By RNA Polymerase I Neuron Projection Guidance Axon Guidance Regulation Of Autophagosome Assembly Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Protein Localization To Cytoskeleton Protein Localization To Astral Microtubule Response To Epidermal Growth Factor Cytoplasmic Microtubule Positive Regulation Of Growth
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