HLA-DRA and PRPF40B

Number of citations of the paper that reports this interaction (PMID 9700202)
73

Data Source:
HPRD (in vivo, in vitro)

		HLA-DRA	PRPF40B
Gene Name		major histocompatibility complex, class II, DR alpha	PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Lysosome Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Nuclear Speck
	Molecular Function	MHC Class II Protein Complex Binding MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Polysaccharide Assembly With MHC Class II Protein Complex Immune Response Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Costimulation T Cell Receptor Signaling Pathway Cognition Interferon-gamma-mediated Signaling Pathway	MRNA Processing RNA Splicing
Pathways		Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs
Diseases
GWAS		Anti-cyclic Citrullinated Peptide Antibody ( 19287509) Asthma ( 23028483 21804548) Complement C3 and C4 levels ( 23028341) Cystic fibrosis severity ( 21602797) Hodgkin's lymphoma ( 21037568 22286212) Lymphoma ( 23349640) Multiple sclerosis ( 17660530) Multiple sclerosis (OCB status) ( 23472185) Non-obstructive azoospermia ( 22541561) Parkinson's disease ( 20711177) Prostate cancer ( 23535732) Pubertal anthropometrics ( 23449627) Rheumatoid arthritis ( 21653640) Systemic sclerosis ( 21779181) Ulcerative colitis ( 23128233 20228798 18836448 21297633 19122664) Vitiligo ( 20410501)
Protein-Protein Interactions		10 interactors: CD63 CD74 CD82 HLA-DMA HLA-DMB HLA-DRB1 HLA-DRB5 MARCH1 MBP PRPF40B	3 interactors: HLA-DRA HTT MECP2
Entrez ID		3122	25766
HPRD ID		00833	11044
Ensembl ID		ENSG00000204287	ENSG00000110844
Uniprot IDs		P01903 Q30118	F8VU11 Q6NWY9
PDB IDs		1A6A 1AQD 1BX2 1D5M 1D5X 1D5Z 1D6E 1DLH 1FV1 1FYT 1H15 1HQR 1HXY 1J8H 1JWM 1JWS 1JWU 1KG0 1KLG 1KLU 1LO5 1PYW 1R5I 1SEB 1SJE 1SJH 1T5W 1T5X 1YMM 1ZGL 2FSE 2G9H 2IAM 2IAN 2ICW 2IPK 2OJE 2Q6W 2SEB 2WBJ 2XN9 3C5J 3L6F 3O6F 3PDO 3PGC 3PGD 3QXA 3QXD 3S4S 3S5L 3T0E 4AEN 4AH2 4E41 4FQX 4GBX 4H1L
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Assembly Antigen Processing And Presentation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Immune Response Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Cell Activation Regulation Of Cell Adhesion Positive Regulation Of Immune Response Immune System Process Positive Thymic T Cell Selection Regulation Of Immune Response Positive Regulation Of Immune System Process Thymic T Cell Selection Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Chaperone Mediated Protein Folding Requiring Cofactor Positive T Cell Selection Regulation Of Immune System Process Regulation Of Interleukin-4 Production Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Response To Cytokine Leukocyte Mediated Immunity T Cell Selection Adaptive Immune Response 'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Cellular Protein Complex Assembly Chaperone-mediated Protein Folding T Cell Costimulation T Cell Differentiation In Thymus Protein Complex Assembly Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Macrophage Migration Inhibitory Factor Signaling Pathway Positive Regulation Of T Cell Differentiation Cytokine-mediated Signaling Pathway Positive Regulation Of Lymphocyte Differentiation Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion T Cell Receptor Signaling Pathway	Cognition Monoamine Transport Social Behavior Visual Learning Visual Behavior Associative Learning Memory Learning Neurological System Process Neural Plate Formation Regulation Of Synaptic Plasticity Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Death Serotonin Uptake Polysaccharide Assembly With MHC Class II Protein Complex Lactate Biosynthetic Process From Pyruvate Locomotory Behavior Regulation Of Neuron Apoptotic Process Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Regulation Of Protein Phosphatase Type 2A Activity Learning Or Memory Regulation Of Membrane Potential Alpha-amino Acid Metabolic Process Regulation Of Neuron Death Response To Hypoxia Catecholamine Secretion Quinolinate Biosynthetic Process Negative Regulation Of Synaptic Transmission, Dopaminergic Regulation Of Synaptic Transmission Blood Circulation Cellular Component Assembly Peptide Antigen Assembly With MHC Class II Protein Complex Lactate Biosynthetic Process Proprioception Response To Light Stimulus Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity MHC Class II Protein Complex Assembly Paraxial Mesoderm Formation Quinolinate Metabolic Process Cellular Response To CGMP Response To CGMP Serotonin Transport Sperm Ejaculation Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Neural Plate Morphogenesis L-glutamate Import Response To Radiation Single-organism Behavior Cellular Amino Acid Metabolic Process
Tagcloud ?			acquisition alleles aml appraise asxl1 discuss dnmt3a idh1 improvements machinery malignancies mll myelogenous past prognostication quo relapse sf1 sf3a1 sf3b1 somatic spliceosomal srsf2 stratification tet2 u2af1 u2af2 unveiled zrsr2
Tagcloud (Difference) ?			acquisition alleles aml appraise asxl1 discuss dnmt3a idh1 improvements machinery malignancies mll myelogenous past prognostication quo relapse sf1 sf3a1 sf3b1 somatic spliceosomal srsf2 stratification tet2 u2af1 u2af2 unveiled zrsr2
Tagcloud (Intersection) ?