PIK3R4 and BECN1

Number of citations of the paper that reports this interaction (PMID 20562859)
242

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfer, affinity chromatography technology)

		PIK3R4	BECN1
Gene Name		phosphoinositide-3-kinase, regulatory subunit 4	beclin 1, autophagy related
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Pore Late Endosome Cytosol Axoneme Membrane Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Nucleus-vacuole Junction	Pre-autophagosomal Structure Nucleus Trans-Golgi Network Cytoplasmic Membrane-bounded Vesicle Extrinsic Component Of Membrane Dendrite Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phagocytic Vesicle
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Protein Binding
	Biological Process	Toll-like Receptor Signaling Pathway Protein Phosphorylation Protein Targeting To Vacuole Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Insulin Receptor Signaling Pathway Macroautophagy Peroxisome Degradation Toll-like Receptor 9 Signaling Pathway Small Molecule Metabolic Process Innate Immune Response Late Endosome To Vacuole Transport	Autophagic Vacuole Assembly Cytokinesis Response To Hypoxia Cellular Defense Response Cellular Response To Nitrogen Starvation Lysosome Organization Negative Regulation Of Cell Proliferation Positive Regulation Of Autophagy Viral Process Positive Regulation Of Macroautophagy CVT Pathway Response To Vitamin E Response To Drug Negative Regulation Of Apoptotic Process Nucleophagy Late Endosome To Vacuole Transport Neuron Development Beta-amyloid Metabolic Process Regulation Of Catalytic Activity Defense Response To Virus Cellular Response To Aluminum Ion Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Mitochondrion Degradation
Pathways		Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the Golgi membrane Insulin receptor signalling cascade Metabolism of lipids and lipoproteins IRS-mediated signalling IRS-related events IGF1R signaling cascade Synthesis of PIPs at the late endosome membrane IRS-related events triggered by IGF1R Toll-Like Receptors Cascades IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Toll Like Receptor 9 (TLR9) Cascade Phospholipid metabolism PI3K Cascade PI3K Cascade Innate Immune System PI Metabolism Signaling by Insulin receptor
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: BECN1 MAPRE1 PIK3C3 YWHAB	15 interactors: AMBRA1 ATG14 ATG3 BCL2 BCL2L1 CASP3 CDKN2A GFI1B GOPC ITCH NEDD4 PIK3R4 TRAF6 WASH1 XPO1
Entrez ID		30849	8678
HPRD ID		04010	05087
Ensembl ID		ENSG00000196455	ENSG00000126581
Uniprot IDs		Q99570	E7EV84 Q14457
PDB IDs			2P1L 2PON 3DVU 4DDP
Enriched GO Terms of Interacting Partners?		Autophagic Vacuole Assembly Cell Division Macroautophagy Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Vacuole Organization Cellular Localization Cytokinesis Cellular Response To Aluminum Ion Cellular Response To Starvation Regulation Of Organelle Organization Insulin Receptor Signaling Pathway Autophagy Positive Regulation Of Mitochondrion Degradation CVT Pathway Cell Cycle Process Cellular Response To Nutrient Levels Response To Starvation Endosomal Transport Positive Regulation Of Microtubule Plus-end Binding Cellular Response To Extracellular Stimulus Cellular Response To Insulin Stimulus Defense Response Cell Cycle Cellular Protein Localization Response To Aluminum Ion Response To Insulin Negative Regulation Of Protein Dephosphorylation Cellular Response To Peptide Hormone Stimulus Intracellular Transport Response To Leucine Late Endosome To Vacuole Transport Cellular Response To Peptide Protein Localization To Microtubule Regulation Of Mitochondrion Degradation Positive Regulation Of Organelle Organization Response To External Stimulus Protein Targeting Cellular Response To Organic Substance Response To Nutrient Levels Cellular Component Assembly Protein Localization Regulation Of Cellular Component Organization Response To Peptide Hormone Response To Extracellular Stimulus Immune Response-regulating Signaling Pathway Establishment Of Localization In Cell Cellular Response To Organonitrogen Compound Organelle Assembly Positive Regulation Of Macroautophagy	Regulation Of Cellular Component Organization Apoptotic Mitochondrial Changes Protein K63-linked Ubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Polyubiquitination Cellular Response To Stress Intracellular Transport Intracellular Receptor Signaling Pathway Regulation Of Execution Phase Of Apoptosis Regulation Of Autophagy Regulation Of Organelle Organization Release Of Cytochrome C From Mitochondria Establishment Of Localization In Cell Protein Ubiquitination Apoptotic Process Negative Regulation Of Cellular Metabolic Process Programmed Cell Death Protein Modification By Small Protein Conjugation Regulation Of Cellular Localization Cellular Response To Starvation Cell Death Death Regulation Of T Cell Proliferation Regulation Of Establishment Of Protein Localization Organelle Organization Autophagy Mitochondrion Organization Regulation Of Lymphocyte Activation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Localization Cellular Response To Nutrient Levels Response To Starvation Regulation Of Protein Localization Regulation Of Intracellular Transport Neuron Apoptotic Process Macroautophagy Response To Stress Regulation Of B Cell Proliferation Regulation Of Cell Activation Neuron Death Cellular Response To Extracellular Stimulus Negative Regulation Of T Cell Proliferation Regulation Of Apoptotic DNA Fragmentation Negative Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Regulation Of Apoptotic Process Negative Regulation Of Leukocyte Proliferation
Tagcloud ?		actionable adamts18 col1a1 d816 dgki epha4 epha7 g12 g13 gna11 gnaq gucy2c k642 kalrn l576 melanomas mined ngs nras ppp6c prkaa2 q209 q61 stk31 taf1l trpm6 v559 v600 w557	antiretroviral antiviral ascribed assemble atg8 autophagic autophagy cargo constitutes defines destruction establishes exemplified explains hitherto machinery nucleate platforms preparation recognizes regulators reminiscent restriction trim trim5 trim5alpha trims tripartite ulk1
Tagcloud (Difference) ?		actionable adamts18 col1a1 d816 dgki epha4 epha7 g12 g13 gna11 gnaq gucy2c k642 kalrn l576 melanomas mined ngs nras ppp6c prkaa2 q209 q61 stk31 taf1l trpm6 v559 v600 w557	antiretroviral antiviral ascribed assemble atg8 autophagic autophagy cargo constitutes defines destruction establishes exemplified explains hitherto machinery nucleate platforms preparation recognizes regulators reminiscent restriction trim trim5 trim5alpha trims tripartite ulk1
Tagcloud (Intersection) ?