PIK3R4 and MAPRE1

Number of citations of the paper that reports this interaction (PMID 12686597)
56

Data Source:
HPRD (in vitro)

		PIK3R4	MAPRE1
Gene Name		phosphoinositide-3-kinase, regulatory subunit 4	microtubule-associated protein, RP/EB family, member 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Pore Late Endosome Cytosol Axoneme Membrane Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Nucleus-vacuole Junction	Cytoplasm Golgi Apparatus Centrosome Spindle Cytosol Microtubule Cytoplasmic Microtubule Cortical Microtubule Cytoskeleton Cell Projection Membrane Microtubule Plus-end
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Protein Binding Protein C-terminus Binding Poly(A) RNA Binding Microtubule Plus-end Binding
	Biological Process	Toll-like Receptor Signaling Pathway Protein Phosphorylation Protein Targeting To Vacuole Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Insulin Receptor Signaling Pathway Macroautophagy Peroxisome Degradation Toll-like Receptor 9 Signaling Pathway Small Molecule Metabolic Process Innate Immune Response Late Endosome To Vacuole Transport	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Mitotic Nuclear Division Cell Proliferation Negative Regulation Of Microtubule Polymerization Protein Localization To Microtubule Cell Division Positive Regulation Of Microtubule Plus-end Binding
Pathways		Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the Golgi membrane Insulin receptor signalling cascade Metabolism of lipids and lipoproteins IRS-mediated signalling IRS-related events IGF1R signaling cascade Synthesis of PIPs at the late endosome membrane IRS-related events triggered by IGF1R Toll-Like Receptors Cascades IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Toll Like Receptor 9 (TLR9) Cascade Phospholipid metabolism PI3K Cascade PI3K Cascade Innate Immune System PI Metabolism Signaling by Insulin receptor	Mitotic Prometaphase Organelle biogenesis and maintenance Separation of Sister Chromatids Assembly of the primary cilium G2/M Transition Mitotic Anaphase Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane M Phase Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Resolution of Sister Chromatid Cohesion Loss of Nlp from mitotic centrosomes Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Recruitment of mitotic centrosome proteins and complexes
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: BECN1 MAPRE1 PIK3C3 YWHAB	40 interactors: ABCB1 APC APC2 APP AURKB BCL3 CDK5RAP2 CLASP1 CLASP2 CLIP1 COPS5 COPS8 CSN3 CYLD DCTN1 HSPA1A IKBKG KAT2B KAT5 KIF2C LMO2 LRP1 MACF1 MAPRE2 MAPRE3 NAV1 NUPR1 PDE4DIP PIK3R4 POLE2 PQBP1 PSMA1 SPDYE2 STK11 TERF1 TRAF2 TRIO TROAP TUBA1A TUBB
Entrez ID		30849	22919
HPRD ID		04010	04379
Ensembl ID		ENSG00000196455	ENSG00000101367
Uniprot IDs		Q99570	B4DM33 Q15691
PDB IDs			1PA7 1TXQ 1UEG 1VKA 1WU9 1YIB 1YIG 2HKQ 2HL3 2HL5 2QJZ 2R8U 3GJO 3TQ7
Enriched GO Terms of Interacting Partners?		Autophagic Vacuole Assembly Cell Division Macroautophagy Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Vacuole Organization Cellular Localization Cytokinesis Cellular Response To Aluminum Ion Cellular Response To Starvation Regulation Of Organelle Organization Insulin Receptor Signaling Pathway Autophagy Positive Regulation Of Mitochondrion Degradation CVT Pathway Cell Cycle Process Cellular Response To Nutrient Levels Response To Starvation Endosomal Transport Positive Regulation Of Microtubule Plus-end Binding Cellular Response To Extracellular Stimulus Cellular Response To Insulin Stimulus Defense Response Cell Cycle Cellular Protein Localization Response To Aluminum Ion Response To Insulin Negative Regulation Of Protein Dephosphorylation Cellular Response To Peptide Hormone Stimulus Intracellular Transport Response To Leucine Late Endosome To Vacuole Transport Cellular Response To Peptide Protein Localization To Microtubule Regulation Of Mitochondrion Degradation Positive Regulation Of Organelle Organization Response To External Stimulus Protein Targeting Cellular Response To Organic Substance Response To Nutrient Levels Cellular Component Assembly Protein Localization Regulation Of Cellular Component Organization Response To Peptide Hormone Response To Extracellular Stimulus Immune Response-regulating Signaling Pathway Establishment Of Localization In Cell Cellular Response To Organonitrogen Compound Organelle Assembly Positive Regulation Of Macroautophagy	Cell Cycle Process Mitotic Cell Cycle Process Cell Cycle Mitotic Cell Cycle Mitotic Nuclear Division Regulation Of Microtubule-based Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Division Regulation Of Microtubule Cytoskeleton Organization Regulation Of Cell Cycle G2/M Transition Of Mitotic Cell Cycle Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Cell Cycle Microtubule Cytoskeleton Organization Microtubule-based Process Response To Stimulus Organelle Organization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Complex Assembly Regulation Of Cytoskeleton Organization Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Microtubule Depolymerization Regulation Of Chromosome Segregation Cullin Deneddylation Cellular Localization Regulation Of Wnt Signaling Pathway Establishment Or Maintenance Of Cell Polarity Response To Radiation Protein Deneddylation Negative Regulation Of Microtubule Polymerization Or Depolymerization Cellular Component Assembly Spindle Checkpoint Positive Regulation Of Microtubule Polymerization Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Component Organization Microtubule Bundle Formation Response To Light Stimulus Cellular Protein Complex Assembly Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Positive Regulation Of Metabolic Process Regulation Of Apoptotic Process Cellular Response To Stimulus Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Positive Regulation Of Transferase Activity
Tagcloud ?		actionable adamts18 col1a1 d816 dgki epha4 epha7 g12 g13 gna11 gnaq gucy2c k642 kalrn l576 melanomas mined ngs nras ppp6c prkaa2 q209 q61 stk31 taf1l trpm6 v559 v600 w557	akap450 akap9 disrupting eb1 endoplasmic fragmentation functioned golgi immunoprecipitation interacting isoform microtubule microtubules mmg8 myomegalin networks newly nucleation obscure organization organizing participates predominantly reticulum thereby tracking trafficking tubulin variant
Tagcloud (Difference) ?		actionable adamts18 col1a1 d816 dgki epha4 epha7 g12 g13 gna11 gnaq gucy2c k642 kalrn l576 melanomas mined ngs nras ppp6c prkaa2 q209 q61 stk31 taf1l trpm6 v559 v600 w557	akap450 akap9 disrupting eb1 endoplasmic fragmentation functioned golgi immunoprecipitation interacting isoform microtubule microtubules mmg8 myomegalin networks newly nucleation obscure organization organizing participates predominantly reticulum thereby tracking trafficking tubulin variant
Tagcloud (Intersection) ?