PIK3R4 and PIK3C3

Number of citations: 0 (PubMedID 8999962)
Data Source: HPRD (in vivo, in vitro)

		PIK3R4	PIK3C3
Name		phosphoinositide-3-kinase regulatory subunit 4	phosphatidylinositol 3-kinase catalytic subunit type 3
Structure
GO Annotations	Cellular Component	Cytoplasm Endosome Late Endosome Autophagosome Cytosol Cytoskeleton Cilium Axoneme Microtubule Cytoskeleton Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III Ciliary Basal Body Intercellular Bridge Nucleus-vacuole Junction	Phagophore Assembly Site Cytoplasm Endosome Late Endosome Autophagosome Peroxisome Cytosol Plasma Membrane Axoneme Membrane Midbody Phagocytic Vesicle Membrane Cytoplasmic Vesicle Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III Autolysosome Phagocytic Vesicle Postsynapse Presynaptic Endosome Postsynaptic Endosome Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor Phosphatidylinositol Kinase Activity
	Biological Process	Pexophagy Protein Phosphorylation Protein Targeting To Lysosome Protein Targeting To Vacuole Regulation Of Autophagy Macroautophagy Regulation Of Macroautophagy Regulation Of Cytokinesis Receptor Catabolic Process Phosphatidylinositol-3-phosphate Biosynthetic Process Cellular Response To Glucose Starvation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Early Endosome To Late Endosome Transport Late Endosome To Vacuole Transport Autophagosome Maturation	Autophagosome Assembly Pexophagy Protein Targeting To Lysosome Lipid Metabolic Process Endocytosis Autophagy Endosome Organization Cellular Response To Starvation Regulation Of Autophagy Macroautophagy Regulation Of Macroautophagy Protein Processing Regulation Of Cytokinesis Protein Localization To Phagophore Assembly Site Phosphatidylinositol-3-phosphate Biosynthetic Process Cellular Response To Glucose Starvation Response To L-leucine Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Host-mediated Activation Of Viral Genome Replication Early Endosome To Late Endosome Transport Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Phosphatidylinositol Phosphate Biosynthetic Process Phosphatidylinositol-mediated Signaling Synaptic Vesicle Endocytosis Cell Division Type II Interferon-mediated Signaling Pathway Interleukin-6-mediated Signaling Pathway Autophagosome Maturation Positive Regulation Of Protein Lipidation
Pathways		PI3K Cascade Macroautophagy Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Toll Like Receptor 9 (TLR9) Cascade RHO GTPases Activate NADPH Oxidases Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC	PI3K Cascade Macroautophagy Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Toll Like Receptor 9 (TLR9) Cascade RHO GTPases Activate NADPH Oxidases Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs		None	N-(5-{4-Chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl}-4-methyl-1,3-thiazol-2-yl)acetamide GSK-1059615
GWAS		Abdominal aortic calcification levels ( 31659325 ) Refractive error ( 32231278 )	Adult body size ( 32376654 ) Blood trace element (Zn levels) ( 23720494 ) Body size at age 10 ( 32376654 ) Frailty index ( 34431594 ) General risk tolerance (MTAG) ( 30643258 ) Major depressive disorder (MTAG) ( 33479212 ) Obese vs. thin ( 30677029 ) Obesity-related traits ( 23251661 ) Periodontitis (PAL4Q3) ( 24024966 ) Walking pace ( 33128006 )
Novel Interactors		2 novel interactors: NPHP3 SMAD6	None recorded
Interacting Genes		6 interacting genes: DSCR9 FNDC3B MAPRE1 PIK3C3 RACK1 YWHAB	12 interacting genes: CALM1 CASP8 FBXL20 KLHL20 OTUD7B PDPK1 PIK3R4 PITPNA STYK1 UBE3C YWHAG YWHAQ
Entrez ID		30849	5289
HPRD ID		04010	04009
Ensembl ID		ENSG00000196455	ENSG00000078142
Uniprot IDs		Q99570	A8MYT4 B4DPV9 Q8NEB9
PDB IDs		7BL1 8SOR 9C82 9MHF 9MHG 9MHH	3IHY 3LS8 4OYS 4PH4 4UWF 4UWG 4UWH 4UWK 4UWL 5ANL 5ENN 6HOG 6HOH 6I3U 6YKG 7BL1 7RSJ 7RSP 7RSV 8RXR 8SOR 9C82 9E4V 9MHF 9MHG 9MHH
GO Terms Enriched among Interactors		Cardiac Septum Development Type I Activin Receptor Binding Protein Sequestering Activity Cadherin Binding IRE1-RACK1-PP2A Complex Negative Regulation Of Translational Frameshifting Non-motile Cilium Assembly Protein Localization To Mitotic Spindle Protein Localization To Astral Microtubule Protein Localization To Spindle Microtubule Determination Of Stomach Left/right Asymmetry Determination Of Intestine Left/right Asymmetry	Proteolysis Involved In Protein Catabolic Process Proteolysis Substantia Nigra Development Intracellular Signal Transduction Cytosol Protein Metabolic Process Protein Modification Process 3-phosphoinositide-dependent Protein Kinase Activity Protein Localization To Lysosome Macromolecule Catabolic Process Cellular Response To Glucose Starvation Modification-dependent Protein Catabolic Process Protein Targeting SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Phosphatidylinositol Phosphate Biosynthetic Process Type II Interferon Binding Nucleus-vacuole Junction Regulation Of Protein Catabolic Process At Presynapse, Modulating Synaptic Transmission Regulation Of Monoatomic Ion Transmembrane Transport Neural Nucleus Development Protein Polyubiquitination Negative Regulation Of TORC1 Signaling TORC1 Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Canonical NF-kappaB Signal Transduction Protein K33-linked Ubiquitination Intracellular Signaling Cassette Regulation Of Cytokinesis Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Canonical NF-kappaB Signal Transduction Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Autophagosome Assembly Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Insulin Stimulus Quaternary Ammonium Group Binding Post-translational Protein Modification Positive Regulation Of TOR Signaling Protein Localization To Vacuole Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of TORC1 Signaling Negative Regulation Of TOR Signaling TOR Signaling Protein Kinase C Inhibitor Activity Autophagosome Organization Phosphatidylinositol Biosynthetic Process Negative Regulation Of Transmembrane Transport